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COREG (carvedilol)
- heart failure with rEF due to dilated cardiomyopathy
- high blood pressure
- left ventricle of heart dysfunction after heart attack
12.5 mg tablet
- 1 tablet (12.5 mg) by oral route 2 times per day with food
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day with food
3.125 mg tablet
- 1 tablet (3.125 mg) by oral route 2 times per day with food
6.25 mg tablet
- 1 tablet (6.25 mg) by oral route 2 times per day with food
12.5 mg tablet
- 1 tablet (12.5 mg) by oral route 2 times per day with food
25 mg tablet
- 1 tablet (25 mg) by oral route 2 times per day with food
3.125 mg tablet
- 1 tablet (3.125 mg) by oral route 2 times per day with food
6.25 mg tablet
- 1 tablet (6.25 mg) by oral route 2 times per day with food
Default screening record
- 1 tablet (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route 2 times per day with food
- 2 tablets (25 mg) by oral route every 12 hours with food
- 1 tablet (25 mg) by oral route every 12 hours with food
- 2 tablets (12.5 mg) by oral route 2 times per day with food
- 2 tablets (12.5 mg) by oral route every 12 hours with food
- 1 tablet (12.5 mg) by oral route 2 times per day with food
- 1 tablet (12.5 mg) by oral route every 12 hours with food
- 1 tablet (3.125 mg) by oral route 2 times per day with food
- 1 tablet (3.125 mg) by oral route every 12 hours with food
- 2 tablets (6.25 mg) by oral route 2 times per day with food
- 2 tablets (6.25 mg) by oral route every 12 hours with food
- 1 tablet (6.25 mg) by oral route 2 times per day with food
- 1 tablet (6.25 mg) by oral route every 12 hours with food
- None
Contraindicated
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- Corlopam
- Duraclon (pf)
- fenoldopam
- fingolimod
- Gilenya
- Hycamtin
- Kapvay
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- topotecan
Severe
Moderate
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- aminophylline
- amiodarone
- amiodarone in dextrose,iso-osm
- Anaprox
- Anaprox Ds
- Ansaid
- Apidra
- Apidra Solostar
- Calan
- Calan Sr
- Caldolor
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Cordarone
- Diabeta
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Duetact
- Duexis
- dyphylline
- Ec-naprosyn
- Elixophyllin
- Feldene
- Flanax
- flurbiprofen
- Gilotrif
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- isoniazid-rifamp-pyrazinamide
- Lantus
- Lantus Solostar
- Levemir
- Levemir Flexpen
- Lufyllin
- Matzim La
- Medi-profen
- Mediproxen
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- Multaq
- Mycobutin
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Neoprofen (ibuprofen Lysn)(pf)
- Nexterone
- Nifedical Xl
- nifedipine
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Pacerone
- pioglitazone-glimepiride
- piroxicam
- Priftin
- Procardia
- Procardia Xl
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Sinus & Cold-d
- Starlix
- sulindac
- Tarka
- Taztia Xt
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- Tiazac
- tolazamide
- tolbutamide
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Vicoprofen
- Vimovo
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Asthma
- Cardiogenic shock
- Complete atrioventricular block
- Pregnancy
- Second degree atrioventricular heart block
Contraindicated
- Acute decompensated heart failure
- Chronic bronchitis
- Chronic obstructive pulmonary disease
- Hypotension
- Pulmonary emphysema
- Sick sinus syndrome
- Sinus bradycardia
Severe
Moderate
- CYp2d6 poor metabolizer
- Diabetes mellitus
- First degree atrioventricular heart block
- Intraoperative floppy iris syndrome
- Myasthenia gravis
- Peripheral vascular disease
- Prinzmetal angina
- Severe hepatic disease
COREG (carvedilol)
- heart failure with rEF due to dilated cardiomyopathy
- high blood pressure
- left ventricle of heart dysfunction after heart attack
- Bradycardia
- Dyspnea
- Hyperglycemia
- Hypotension
- Orthostatic hypotension
- Peripheral edema
- Back pain
- Diarrhea
- Dizziness
- Fatigue
- Paresthesia
- Weight gain
More Frequent
Severe
Less Severe
- Anemia
- Atrioventricular block
- Depression
- Edema
- Increased alanine transaminase
- Increased aspartate transaminase
- Jaundice
- Pulmonary edema
- Purpura
- Thrombocytopenic disorder
- Arthralgia
- Blurred vision
- Chest pain
- Cough
- Cramps
- Drowsy
- Erectile dysfunction
- Fever
- Flu-like symptoms
- General weakness
- Headache disorder
- Hematuria
- Hyperhidrosis
- Hypoesthesia
- Insomnia
- Malaise
- Myalgia
- Nausea
- Palpitations
- Pharyngitis
- Proteinuria
- Pruritus of skin
- Rhinitis
- Vertigo
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angina
- Angioedema
- Aplastic anemia
- Asthma exacerbation
- Erythema multiforme
- Hypovolemia
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Stevens-johnson syndrome
- Syncope
- Toxic epidermal necrolysis
- Urticaria
- Worsening of chronic heart failure
Less Severe
- Black tarry stools
- Hypercholesterolemia
- Hypertension
- Hyperuricemia
- Urinary incontinence
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Carvedilol
Efficacy not established age < 18 years.
- 1 Day – 18 Years
- Efficacy not established age < 18 years.
Carvedilol
- Severity Level:
1
- Additional Notes: Beta blockers w/isa may cause intrauterine growth restriction
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Carvedilol
Monitor for signs of b-blockade, bradycardia,hypotension
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Monitor for signs of b-blockade, bradycardia,hypotension |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Carvedilol
Cardiovascular-Minimize dose to decrease dizziness and falls. Plasma levels as much as 50% higher in the elderly.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | N | Y | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Heart failure with rEF due to dilated cardiomyopathy | |
| I25.5 | Ischemic cardiomyopathy |
| I42.0 | Dilated cardiomyopathy |
| I42.6 | Alcoholic cardiomyopathy |
| I50.2 | Systolic (congestive) heart failure |
| I50.20 | Unspecified systolic (congestive) heart failure |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.23 | Acute on chronic systolic (congestive) heart failure |
| I50.4 | Combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.40 | Unspecified combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.43 | Acute on chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Left ventricular dysfunction following MI | |
| I23.8 | Other current complications following acute myocardial infarction |
| I50.1 | Left ventricular failure, unspecified |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| I23.8 | Other current complications following acute myocardial infarction |
| I25.5 | Ischemic cardiomyopathy |
| I42.0 | Dilated cardiomyopathy |
| I42.6 | Alcoholic cardiomyopathy |
| I50.1 | Left ventricular failure, unspecified |
| I50.2 | Systolic (congestive) heart failure |
| I50.20 | Unspecified systolic (congestive) heart failure |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.23 | Acute on chronic systolic (congestive) heart failure |
| I50.4 | Combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.40 | Unspecified combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.43 | Acute on chronic combined systolic (congestive) and diastolic (congestive) heart failure |
Formulary Reference Tool