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DUREZOL (difluprednate)
- inflammation of the eye following surgery
- inflammation of the front portion of the eye
- postoperative pain in eye
0.05 % eye drops
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
Anterior uveitis
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
Post-op ocular inflammation
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
Postoperative ocular pain
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- Instill 1 drop into both eyes by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into right eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into left eye by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs post op x 2 wks; then 2 times/day x 7 days; then taper
- Instill 1 drop into affected eye(s) by ophthalmic route 4 times per day ;Start 24Hrs after surgery, continue for the first 2 weeks of post-op period; decrease to 2 times per day for 1 week; then taper based upon response
- None
Contraindicated
- None
Severe
Moderate
- None
- Fungal keratitis
- Herpes simplex dendritic keratitis
- Herpes zoster keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
Contraindicated
- Bacterial keratitis
Severe
Moderate
- Ocular hypertension
DUREZOL (difluprednate)
- inflammation of the eye following surgery
- inflammation of the front portion of the eye
- postoperative pain in eye
- None
- Blurred vision
More Frequent
Severe
Less Severe
- Ocular hypertension
- Headache disorder
- Iritis
- Ocular pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Adrenocortical insufficiency
- Cataracts
- Central serous chorioretinopathy
- Corneal degeneration
- Corneal edema
- Corneal erosion
- Corneal ulcer
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Hypercortisolism
- Hypersensitivity drug reaction
- Keratitis
- Optic nerve damage
- Punctate keratitis
- Reduced visual acuity
- Uveitis
- Visual changes
- Visual field defect
Less Severe
- Accommodation disorder
- Allergic dermatitis
- Blepharoptosis
- Chemosis
- Conjunctival hyperemia
- Conjunctivitis
- Dizziness
- Dysgeusia
- Eye tearing
- Foreign body sensation of eye
- Impaired wound healing
- Mydriasis
- Ocular infection
- Ocular irritation
- Ocular itching
- Ocular redness
- Photophobia
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Difluprednate (ophthalmic)
- Severity Level:
C
- Additional Notes: Systemic absorption unkn; dev tox in animals after systemic exposure
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Difluprednate
Amount of systemic absorption unknown, caution advised.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Amount of systemic absorption unknown, caution advised. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Anterior uveitis | |
| H20 | Iridocyclitis |
| H20.0 | Acute and subacute iridocyclitis |
| H20.00 | Unspecified acute and subacute iridocyclitis |
| H20.01 | Primary iridocyclitis |
| H20.011 | Primary iridocyclitis, right eye |
| H20.012 | Primary iridocyclitis, left eye |
| H20.013 | Primary iridocyclitis, bilateral |
| H20.019 | Primary iridocyclitis, unspecified eye |
| H20.02 | Recurrent acute iridocyclitis |
| H20.021 | Recurrent acute iridocyclitis, right eye |
| H20.022 | Recurrent acute iridocyclitis, left eye |
| H20.023 | Recurrent acute iridocyclitis, bilateral |
| H20.029 | Recurrent acute iridocyclitis, unspecified eye |
| H20.03 | Secondary infectious iridocyclitis |
| H20.031 | Secondary infectious iridocyclitis, right eye |
| H20.032 | Secondary infectious iridocyclitis, left eye |
| H20.033 | Secondary infectious iridocyclitis, bilateral |
| H20.039 | Secondary infectious iridocyclitis, unspecified eye |
| H20.04 | Secondary noninfectious iridocyclitis |
| H20.041 | Secondary noninfectious iridocyclitis, right eye |
| H20.042 | Secondary noninfectious iridocyclitis, left eye |
| H20.043 | Secondary noninfectious iridocyclitis, bilateral |
| H20.049 | Secondary noninfectious iridocyclitis, unspecified eye |
| H20.1 | Chronic iridocyclitis |
| H20.10 | Chronic iridocyclitis, unspecified eye |
| H20.11 | Chronic iridocyclitis, right eye |
| H20.12 | Chronic iridocyclitis, left eye |
| H20.13 | Chronic iridocyclitis, bilateral |
| H20.2 | Lens-induced iridocyclitis |
| H20.20 | Lens-induced iridocyclitis, unspecified eye |
| H20.21 | Lens-induced iridocyclitis, right eye |
| H20.22 | Lens-induced iridocyclitis, left eye |
| H20.23 | Lens-induced iridocyclitis, bilateral |
| H20.9 | Unspecified iridocyclitis |
| Post-op ocular inflammation | |
| H57.8 | Other specified disorders of eye and adnexa |
| Postoperative ocular pain | |
| H57.1 | Ocular pain |
| H57.10 | Ocular pain, unspecified eye |
| H57.11 | Ocular pain, right eye |
| H57.12 | Ocular pain, left eye |
| H57.13 | Ocular pain, bilateral |
| 0-9 | A-Z |
|---|---|
| H20 | Iridocyclitis |
| H20.0 | Acute and subacute iridocyclitis |
| H20.00 | Unspecified acute and subacute iridocyclitis |
| H20.01 | Primary iridocyclitis |
| H20.011 | Primary iridocyclitis, right eye |
| H20.012 | Primary iridocyclitis, left eye |
| H20.013 | Primary iridocyclitis, bilateral |
| H20.019 | Primary iridocyclitis, unspecified eye |
| H20.02 | Recurrent acute iridocyclitis |
| H20.021 | Recurrent acute iridocyclitis, right eye |
| H20.022 | Recurrent acute iridocyclitis, left eye |
| H20.023 | Recurrent acute iridocyclitis, bilateral |
| H20.029 | Recurrent acute iridocyclitis, unspecified eye |
| H20.03 | Secondary infectious iridocyclitis |
| H20.031 | Secondary infectious iridocyclitis, right eye |
| H20.032 | Secondary infectious iridocyclitis, left eye |
| H20.033 | Secondary infectious iridocyclitis, bilateral |
| H20.039 | Secondary infectious iridocyclitis, unspecified eye |
| H20.04 | Secondary noninfectious iridocyclitis |
| H20.041 | Secondary noninfectious iridocyclitis, right eye |
| H20.042 | Secondary noninfectious iridocyclitis, left eye |
| H20.043 | Secondary noninfectious iridocyclitis, bilateral |
| H20.049 | Secondary noninfectious iridocyclitis, unspecified eye |
| H20.1 | Chronic iridocyclitis |
| H20.10 | Chronic iridocyclitis, unspecified eye |
| H20.11 | Chronic iridocyclitis, right eye |
| H20.12 | Chronic iridocyclitis, left eye |
| H20.13 | Chronic iridocyclitis, bilateral |
| H20.2 | Lens-induced iridocyclitis |
| H20.20 | Lens-induced iridocyclitis, unspecified eye |
| H20.21 | Lens-induced iridocyclitis, right eye |
| H20.22 | Lens-induced iridocyclitis, left eye |
| H20.23 | Lens-induced iridocyclitis, bilateral |
| H20.9 | Unspecified iridocyclitis |
| H57.1 | Ocular pain |
| H57.10 | Ocular pain, unspecified eye |
| H57.11 | Ocular pain, right eye |
| H57.12 | Ocular pain, left eye |
| H57.13 | Ocular pain, bilateral |
| H57.8 | Other specified disorders of eye and adnexa |
Formulary Reference Tool