ENALAPRIL-HYDROCHLOROTHIAZIDE (ENALAPRIL MALEATE/HYDROCHLOROTHIAZIDE)
- Hypertension
10 mg-25 mg tablet
- 1 tablet by oral route once daily
enalapril 10 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route once daily
enalapril 5 mg-hydrochlorothiazide 12.5 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- 1 tablet by oral route 2 times per day
- 2 tablets by oral route 2 times per day
- 2 tablets by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Amturnide
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- lithium carbonate
- lithium citrate
- Lithobid
- methenamine mand-sod biphos
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- Uroqid-acid No.2
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- Amaryl
- Anacin
- Anacin Maximum Strength
- Analgesic
- Angeliq
- Antacid & Pain Relief
- Apidra
- Apidra Solostar
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-trin
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Azasan
- azathioprine
- azathioprine sodium
- Back & Body Pain Reliever
- Bactrim
- Bactrim Ds
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Beyaz
- Buffered Aspirin
- Bufferin
- bumetanide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- chlorphen-phenyleph-DM-aspirin
- chlorphenir-phenylephrn-aspirn
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- codeine-butalbital-ASA-caff
- Cold Relief
- Cold Relief Plus
- Colestid
- Colestid Flavored
- colestipol
- Demadex
- Diabeta
- diazoxide
- Digox
- digoxin
- dihydrocodeine-aspirin-caff
- doxylamine-phenylep-DM-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Duetact
- E.c. Prin
- Ecotrin
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Endodan
- ethacrynate sodium
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Fiorinal
- Fiorinal-codeine #3
- furosemide
- Gianvi (28)
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- Imuran
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levacet
- Levemir
- Levemir Flexpen
- Lite Coat Aspirin
- Loryna (28)
- Medi-seltzer
- mercaptopurine
- miglitol
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- nateglinide
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Ocella
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Percodan
- pioglitazone-glimepiride
- Precose
- Prevalite
- Primsol
- Proglycem
- Purinethol
- Questran
- Questran Light
- Safyral
- Sodium Edecrin
- Starlix
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Super Pain Relief
- Syeda
- Synalgos-dc
- tolazamide
- tolbutamide
- torsemide
- Tri-buffered Aspirin
- trimethoprim
- Vanquish
- Vestura (28)
- Yasmin (28)
- Yaz 28
- Zarah
- Angioedema
- Anuria
- Hereditary angioedema
- Pregnancy
Contraindicated
- Acute pancreatitis
- Azotemia
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Dehydration
- Gout
- Hemodialysis with high-flux membrane
- Hepatic failure
- Hyperkalemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypotension
- Hypovolemia
- Neonatal hyperbilirubinemia
- Renal artery stenosis
- Secondary angle-closure glaucoma
Severe
Moderate
- Aortic valve stenosis
- Basal cell carcinoma of skin
- Bone marrow depression
- Cerebrovascular insufficiency
- Diabetes mellitus
- Disease of liver
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Hypertrophic cardiomyopathy
- Immunosuppression
- Neutropenic disorder
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
ENALAPRIL-HYDROCHLOROTHIAZIDE (ENALAPRIL MALEATE/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Cough
- Dizziness
More Frequent
Severe
Less Severe
- Fever
- Hyperglycemia
- Hyperkalemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Arthralgias
- Bronchitis
- Diarrhea
- Dizziness
- Dysgeusia
- Dyspnea
- Fatigue
- General weakness
- Headache disorder
- Nausea
- Orthostatic hypotension
- Skin rash
- Syncope
- Vertigo
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute pancreatitis
- Acute renal failure
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Atrial fibrillation
- Bradycardia
- Bronchospastic pulmonary disease
- Chest pain
- Drug-induced hepatitis
- Eosinophilia
- Eosinophilic pneumonia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Head and neck angioedema
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Ileus
- Interstitial nephritis
- Interstitial pneumonitis
- Intestinal angioedema
- Jaundice
- Laryngeal edema
- Leukocytosis
- Leukopenia
- Myopia
- Myositis
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pemphigus
- Pharyngeal edema
- Pulmonary edema
- Pulmonary thromboembolism
- Purpura
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Tachycardia
- Thrombocytopenic disorder
- Tongue swelling
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Acute confusion
- Anorexia
- Ataxia
- Basal cell carcinoma of skin
- Black tarry stools
- Blurred vision
- Conjunctivitis
- Constipation
- Cramps
- Depression
- Drowsy
- Dyspepsia
- Erectile dysfunction
- Fever
- Flushing
- Gastrointestinal irritation
- General weakness
- Glossitis
- Gynecomastia
- Headache disorder
- Hypercholesterolemia
- Hyperhidrosis
- Hypertriglyceridemia
- Loss of sense of smell
- Muscle spasm
- Myalgias
- Nervousness
- Paresthesia
- Pruritus of skin
- Raynaud's phenomenon
- Sialoadenitis
- Skin photosensitivity
- Skin rash
- Stomatitis
- Tinnitus
- Urticaria
- Vertigo
- Xanthopsia
Contraindicated
None
Severe Precaution
Enalapril (Oral)
Not recommended in neonates or with CrCL <30mL/min.
- 1 Day – 29 Days
- Not recommended in neonates or with CrCL <30mL/min.
Management or Monitoring Precaution
Enalapril-Hydrochlorothiazide
No pediatric safety and efficacy data for combination product.
- 30 Days – 18 Years
- No pediatric safety and efficacy data for combination product.
Enalapril
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Enalapril
Limited data suggest minimal excretion resulting in no adv effects in infant
Limited amounts excreted with no known adverse effects in infant.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal excretion resulting in no adv effects in infant |
Hydrochlorothiazide
Limited data suggest minimal excretion resulting in no adv effects in infant
Limited amounts excreted with no known adverse effects in infant.
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Enalapril
Cardiovascular-Monitor for hypotension. Renal-May increase serum creatinine. Hyperkalemia risk increases with renal insufficiency. Adjust dose for CrCL <31 mL/minute.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
Hydrochlorothiazide
Cardiovascular-Monitor for hypotension. Renal-May increase serum creatinine. Hyperkalemia risk increases with renal insufficiency. Adjust dose for CrCL <31 mL/minute.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant or think you may be pregnant, contact your doctor right away.
Hypertension | |
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
0-9 | A-Z |
---|---|
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |