TRANDOLAPRIL-VERAPAMIL ER (TRANDOLAPRIL/VERAPAMIL HCL)

Moderate

• Abstral

• acebutolol

• Actiq

• Added Strength Headache Relief

• Added Strength Pain Reliever

• Advicor

• afatinib

• Afinitor

• Afinitor Disperz

• Alfenta

• alfentanil

• Alka-seltzer

• Alka-seltzer Extra Strength

• Alka-seltzer Original

• Alka-seltzer Plus C/c(pe,dm)

• Alka-seltzer Plus Cold (pe)

• Alka-seltzer Plus Day-night

• Alka-seltzer Plus Night

• Alka-seltzer Pm

• Altoprev

• amlodipine-atorvastatin

• Anacin

• Anacin Maximum Strength

• Analgesic

• Angeliq

• Antacid & Pain Relief

• Anti-diarrhea

• Anti-diarrheal (lope)-anti-gas

• Anti-diarrheal (loperamide)

• ASA-acetaminophen-caff-buffers

• ASA-acetaminophen-salicyl-caff

• Ascomp With Codeine

• Aspir-trin

• aspirin

• aspirin, buffered

• aspirin-acetaminophen-caffeine

• aspirin-caffeine

• aspirin-diphenhydramine

• aspirin-diphenhydramine citrat

• aspirin-sod bicarb-citric acid

• Astagraf Xl

• atenolol

• atenolol-chlorthalidone

• atorvastatin

• avanafil

• Azasan

• azathioprine

• azathioprine sodium

• B cplx-C-St.Johnwrt-K.&S.ginsg

• Back & Body Pain Reliever

• Bactrim

• Bactrim Ds

• Bayer Advanced

• Bayer Aspirin

• Bayer Aspirin (with Caffeine)

• Bayer Back & Body

• Bayer Plus Extra Strength

• Bayer Pm

• Bc

• Bc Arthritis

• Betapace

• Betapace Af

• Betimol

• Beyaz

• boceprevir

• bosentan

• brimonidine-timolol

• Buffered Aspirin

• Bufferin

• bumetanide

• buspirone

• Butalbital Compound W/codeine

• Butalbital Compound-codeine

• butalbital-aspirin-caffeine

• Bystolic

• Caduet

• calcium-mag-B complex-D3-hrb61

• carbamazepine

• Carbatrol

• carisoprodol-ASA-codeine

• carisoprodol-aspirin

• chlorphen-phenyleph-DM-aspirin

• chlorphenir-phenylephrn-aspirn

• cilostazol

• codeine-butalbital-ASA-caff

• Cold & Flu Fighter

• Cold Relief

• Cold Relief Plus

• Combigan

• Corgard

• Corzide

• Cosopt

• Cosopt Pf

• cyclosporine

• cyclosporine modified

• Demadex

• dextromethorphan-quinidine

• Diamode

• dihydrocodeine-aspirin-caff

• dorzolamide-timolol

• dorzolamide-timolol (PF)

• doxylamine-phenylep-DM-aspirin

• dronedarone

• drospirenone-e.estradiol-lm.FA

• drospirenone-estradiol

• drospirenone-ethinyl estradiol

• Duragesic

• dutasteride-tamsulosin

• Dutoprol

• E.c. Prin

• Ecotrin

• Efferves Pain Relief Antacid

• Effervescent Antacid

• Effervescent Pain Relief

• Effervescent Pain Reliever

• Endocet

• Endodan

• Epitol

• eplerenone

• Equetro

• ethacrynate sodium

• Etopophos

• etoposide

• etoposide phosphate

• everolimus

• Excedrin Extra Strength

• Excedrin Migraine

• Extra Strength Bayer

• ezetimibe-atorvastatin

• Fatigue Relief Complex

• fentanyl

• fentanyl citrate

• fentanyl citrate (PF)

• Fentora

• Fiorinal

• Fiorinal-codeine #3

• Flomax

• furosemide

• Gengraf

• Gianvi (28)

• Gilotrif

• Goody's Extra Strength

• Goody's Migraine Relief

• Headache Formula

• Headache Formula Added Str

• Headache Relief

• Hecoria

• ibuprofen-oxycodone

• Imodium Multi-symptom Relief

• Imuran

• Incivek

• Inderal La

• Inderal Xl

• Innopran Xl

• Inspra

• isoniazid-rifamp-pyrazinamide

• Istalol

• ivacaftor

• Jalyn

• Kalydeco

• ketoconazole

• labetalol

• Lasix

• Latuda

• Lazanda

• Levacet

• Levitra

• Lipitor

• Liptruzet

• Lite Coat Aspirin

• Lo-peramide

• loperamide

• loperamide-simethicone

• Lopressor

• Lopressor Hct

• Loryna (28)

• lovastatin

• lurasidone

• Medi-seltzer

• mercaptopurine

• metoprolol su-hydrochlorothiaz

• metoprolol succinate

• metoprolol ta-hydrochlorothiaz

• metoprolol tartrate

• Mevacor

• Migraine Formula

• Migraine Pain Reliever

• Migraine Relief

• Minipress

• Multaq

• Mycobutin

• nadolol

• nadolol-bendroflumethiazide

• nebivolol

• Neoral

• niacin-lovastatin

• Nuedexta

• Ocella

• Orphenadrine Compound Forte

• Orphenadrine Compound-ds

• orphenadrine-ASA-caffeine

• Oxecta

• oxycodone

• oxycodone-acetaminophen

• oxycodone-aspirin

• Oxycontin

• Pain Relief

• Pain Relief Extra Strength

• Pain Reliever

• Pain Reliever Extra Strength

• Pain Reliever Plus

• Pain-off

• Pamprin Max

• PE-DM-ASA/doxyla-PE-DM-ASA

• Percocet

• Percodan

• pindolol

• Pletal

• prazosin

• Priftin

• Primlev

• Primsol

• Prograf

• propranolol

• propranolol-hydrochlorothiazid

• Purinethol

• quinidine gluconate

• quinidine sulfate

• Rapamune

• rifabutin

• Rifadin

• Rifamate

• rifampin

• rifampin-isoniazid

• rifapentine

• Rifater

• Roxicet

• Safyral

• Sandimmune

• Sectral

• simvastatin

• sirolimus

• Sodium Edecrin

• Sorine

• sotalol

• Sotalol Af

• St. John's wort

• Stendra

• Sublimaze (pf)

• Subsys

• sulfamethoxazole-trimethoprim

• Sulfatrim

• Super Pain Relief

• Syeda

• Synalgos-dc

• tacrolimus

• tamsulosin

• Tegretol

• Tegretol Xr

• telaprevir

• temsirolimus

• Tenoretic 100

• Tenoretic 50

• Tenormin

• terazosin

• timolol

• timolol maleate

• timolol maleate (PF)

• Timoptic

• Timoptic Ocudose (pf)

• Timoptic-xe

• Toposar

• Toprol Xl

• Torisel

• torsemide

• Tracleer

• Trandate

• Tri-buffered Aspirin

• trimethoprim

• Ultra A-d

• Vanquish

• vardenafil

• Vestura (28)

• Victrelis

• vit C-St. John wort-elder-hb30

• Vytorin 10-10

• Women's Complex

• Xartemis Xr

• Yasmin (28)

• Yaz 28

• Zarah

• Zocor

• Zortress

Moderate

• Agranulocytosis

• Bone marrow depression

• Disease of liver

• Kidney disease with reduction in GFR

• Neutropenic disorder

• Renal artery stenosis

Trandolapril

• Severity Level:

  1

• Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected

Verapamil Hydrochloride

• Severity Level:

  C

• Additional Notes:

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Trandolapril

Excreted in rats; insufficient human data available; mfr does not rec

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Excreted in rats; insufficient human data available; mfr does not rec

No Known Risk

Verapamil Hydrochloride

Limited data suggest infant levels are low with no resulting adverse effects

General	Excretion Potential	Effect on Infant	Notes
No known risks; does not adversely affect lactation	Excreted	Not known; no or inclusive data	Limited data suggest infant levels are low with no resulting adverse effects

Contraindicated

None

Precaution Exists

Trandolapril

General-Monitor for increased serum creatinine or hyperkalemia. Cardiovascular-Monitor for hypotension.

Cardiovascular-Elderly are more sensitive to blood pressure lowering effects and may have lower drug clearance. Start at lower doses and titrate upward more slowly. May promote fluid retention and exacerbate heart failure. Gastrointestinal-may cause or worsen pre-existing constipation.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	N	Y	N	N	N

BEERS: N     HEDIS: N     STOPP: Y

Verapamil

General-Monitor for increased serum creatinine or hyperkalemia. Cardiovascular-Monitor for hypotension.

Cardiovascular-Elderly are more sensitive to blood pressure lowering effects and may have lower drug clearance. Start at lower doses and titrate upward more slowly. May promote fluid retention and exacerbate heart failure. Gastrointestinal-may cause or worsen pre-existing constipation.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	N	N	N

BEERS: Y     HEDIS: N     STOPP: Y

No Known Risk

None

0-9	A-Z
I10	Essential (primary) hypertension
I11	Hypertensive heart disease
I11.0	Hypertensive heart disease with heart failure
I11.9	Hypertensive heart disease without heart failure
I12	Hypertensive chronic kidney disease
I12.0	Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13	Hypertensive heart and chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.1	Hypertensive heart and chronic kidney disease without heart failure
I13.10	Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
I13.2	Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease
I15.1	Hypertension secondary to other renal disorders