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Drug overview for MENOPUR (menotropins):
Generic name: MENOTROPINS (men-oh-TROW-pins)
Drug class: Follicle-Stimulating Hormone (FSH)
Therapeutic class: Endocrine
Menotropins is a purified preparation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are human pituitary gonadotropins extracted from urine of postmenopausal women.
No enhanced Uses information available for this drug.
Generic name: MENOTROPINS (men-oh-TROW-pins)
Drug class: Follicle-Stimulating Hormone (FSH)
Therapeutic class: Endocrine
Menotropins is a purified preparation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are human pituitary gonadotropins extracted from urine of postmenopausal women.
No enhanced Uses information available for this drug.
DRUG IMAGES
MENOPUR 75 UNIT VIAL
The following indications for MENOPUR (menotropins) have been approved by the FDA:
Indications:
Follicle stimulation for assisted fertilization procedure
Professional Synonyms:
Multifollicular development for assisted reproductive technologies
Indications:
Follicle stimulation for assisted fertilization procedure
Professional Synonyms:
Multifollicular development for assisted reproductive technologies
The following dosing information is available for MENOPUR (menotropins):
Dosage of menotropins is expressed in international units (IU, units) of FSH and LH activity; each unit of menotropins represents 1 unit of FSH and 1 unit of LH activity.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| MENOPUR 75 UNIT VIAL | Maintenance | Adults inject 225 unit by subcutaneous route once daily |
No generic dosing information available.
The following drug interaction information is available for MENOPUR (menotropins):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for MENOPUR (menotropins):
Drug contraindication overview.
Known hypersensitivity to menotropins or any ingredient in the formulation. Primary ovarian failure (as indicated by high concentrations of follicle-stimulating hormone (FSH)), uncontrolled non-gonadal endocrinopathies (e.g., thyroid, adrenal, pituitary disorders), or tumors of the pituitary gland or hypothalamus. Abnormal intrauterine bleeding of undetermined origin, ovarian cysts or enlargement of undetermined origin (not due to polycystic ovary syndrome (PCOS)), or sex-hormone-dependent tumors of the reproductive tract and accessory organs. Pregnancy.
Known hypersensitivity to menotropins or any ingredient in the formulation. Primary ovarian failure (as indicated by high concentrations of follicle-stimulating hormone (FSH)), uncontrolled non-gonadal endocrinopathies (e.g., thyroid, adrenal, pituitary disorders), or tumors of the pituitary gland or hypothalamus. Abnormal intrauterine bleeding of undetermined origin, ovarian cysts or enlargement of undetermined origin (not due to polycystic ovary syndrome (PCOS)), or sex-hormone-dependent tumors of the reproductive tract and accessory organs. Pregnancy.
There are 7 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Estrogen-dependent neoplasm |
| Hormone receptor positive breast cancer |
| Malignant neoplasm of the ovary |
| Malignant neoplasm of the uterus |
| Pituitary neoplasm |
| Pregnancy |
| Tumor of hypothalamus |
There are 8 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Abnormal uterine bleeding |
| Acute respiratory distress syndrome |
| Ovarian hyperstimulation syndrome |
| Severe adrenal insufficiency |
| Thromboembolic disorder |
| Thrombophilia |
| Torsion of ovary |
| Untreated hypothyroidism |
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Morbid obesity |
The following adverse reaction information is available for MENOPUR (menotropins):
Adverse reaction overview.
Adverse effects reported in at least 2% of women (occurring on or after gonadotropin-releasing hormone (GnRH) administration) undergoing IVF and ICSI receiving menotropins subcutaneously include abdominal pain, headache, OHSS, injection site pain and reaction, abdominal cramps, abdominal enlargement, and injection site inflammation.
Adverse effects reported in at least 2% of women (occurring on or after gonadotropin-releasing hormone (GnRH) administration) undergoing IVF and ICSI receiving menotropins subcutaneously include abdominal pain, headache, OHSS, injection site pain and reaction, abdominal cramps, abdominal enlargement, and injection site inflammation.
There are 9 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Injection site sequelae Ovarian cyst Ovarian enlargement Ovarian hyperstimulation syndrome |
None. |
| Rare/Very Rare |
|---|
|
Atelectasis Malignant neoplasm of the ovary Skin rash Thromboembolic disorder Torsion of ovary |
There are 13 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Abdominal pain with cramps Headache disorder Multiple pregnancy Nausea |
Abdominal distension Dizziness Mastalgia Pain Pelvic pain Vomiting |
| Rare/Very Rare |
|---|
|
Acne vulgaris Diarrhea Flushing |
The following precautions are available for MENOPUR (menotropins):
Safety and efficacy not established. Not indicated for use in pediatric patients.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
Category X. (See Users Guide.) Menotropins may cause fetal harm when administered to a pregnant woman. Menotropins is contraindicated in pregnant women. (See Contraindications.)
It is not known whether menotropins is distributed into human milk. Because of the potential for serious adverse reactions to menotropins in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
Not indicated for use in geriatric patients.
The following prioritized warning is available for MENOPUR (menotropins):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for MENOPUR (menotropins)'s list of indications:
| Follicle stimulation for assisted fertilization | |
| Z31.83 | Encounter for assisted reproductive fertility procedure cycle |
| Z31.89 | Encounter for other procreative management |
| Z52.81 | Egg (oocyte) donor |
| Z52.810 | Egg (oocyte) donor under age 35, anonymous recipient |
| Z52.811 | Egg (oocyte) donor under age 35, designated recipient |
| Z52.812 | Egg (oocyte) donor age 35 and over, anonymous recipient |
| Z52.813 | Egg (oocyte) donor age 35 and over, designated recipient |
| Z52.819 | Egg (oocyte) donor, unspecified |
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