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DILTIAZEM 24HR ER (CD) (diltiazem HCl)
- Hypertension
- Prevention of anginal pain in coronary artery disease
- Diltiazem Cd Capsule,extended Release 24 Hr
- Cartia Xt Capsule,extended Release
- Cardizem Cd Capsule,extended Release
- By Indication
diltiazem CD 120 mg capsule,extended release 24 hr
- 1 capsule (120 mg) by oral route once daily
diltiazem CD 180 mg capsule,extended release 24 hr
- 1 capsule (180 mg) by oral route once daily
diltiazem CD 240 mg capsule,extended release 24 hr
- 1 capsule (240 mg) by oral route once daily
diltiazem CD 300 mg capsule,extended release 24 hr
- 1 capsule (300 mg) by oral route once daily
diltiazem CD 360 mg capsule,extended release 24 hr
- 1 capsule (360 mg) by oral route once daily
120 mg capsule,extended release
- 1 capsule (120 mg) by oral route once daily
180 mg capsule,extended release
- 1 capsule (180 mg) by oral route once daily
240 mg capsule,extended release
- 1 capsule (240 mg) by oral route once daily
300 mg capsule,extended release
- 1 capsule (300 mg) by oral route once daily
120 mg capsule,extended release
- 1 capsule (120 mg) by oral route once daily
180 mg capsule,extended release
- 1 capsule (180 mg) by oral route once daily
240 mg capsule,extended release
- 1 capsule (240 mg) by oral route once daily
300 mg capsule,extended release
- 1 capsule (300 mg) by oral route once daily
360 mg capsule,extended release
- 1 capsule (360 mg) by oral route once daily
Hypertension
- 1 capsule (180 mg) by oral route once daily
- 2 capsules (240 mg) by oral route once daily
- 1 capsule (240 mg) by oral route once daily
- 1 capsule (300 mg) by oral route once daily
- 2 capsules (360 mg) by oral route once daily
- 1 capsule (360 mg) by oral route once daily
- 2 capsules (480 mg) by oral route once daily
- 3 capsules (540 mg) by oral route once daily
Prevention of anginal pain in coronary artery disease
- 1 capsule (120 mg) by oral route once daily
- 1 capsule (180 mg) by oral route once daily
- 2 capsules (240 mg) by oral route once daily
- 1 capsule (240 mg) by oral route once daily
- 2 capsules (360 mg) by oral route once daily
- 1 capsule (360 mg) by oral route once daily
- 2 capsules (480 mg) by oral route once daily
- 3 capsules (540 mg) by oral route once daily
- Advicor
- Altoprev
- ezetimibe-simvastatin
- Juxtapid
- lomitapide
- lovastatin
- Mevacor
- niacin-lovastatin
- niacin-simvastatin
- Simcor
- simvastatin
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Zocor
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- amoxicil-clarithromy-lansopraz
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- Bosulif
- bosutinib
- clarithromycin
- colchicine
- colchicine-probenecid
- Colcrys
- Cordarone
- Dantrium
- dantrolene
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- fingolimod
- Gilenya
- guanfacine
- Hycamtin
- Intuniv Er
- Ketek
- midazolam
- midazolam (PF)
- Nexterone
- Olysio
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Orap
- Pacerone
- pimozide
- Prevpac
- Revonto
- Samsca
- simeprevir
- telithromycin
- Tenex
- tolvaptan
- topotecan
- triazolam
Severe
Moderate
- Abstral
- acebutolol
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- amlodipine-atorvastatin
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Astagraf Xl
- atazanavir
- atenolol
- atenolol-chlorthalidone
- atorvastatin
- avanafil
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Betapace
- Betapace Af
- Betimol
- boceprevir
- bosentan
- brimonidine-timolol
- buspirone
- Bystolic
- Caduet
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- cilostazol
- cimetidine
- Cold & Flu Fighter
- Combigan
- Corgard
- Corzide
- Cosopt
- Cosopt Pf
- cyclosporine
- cyclosporine modified
- dextromethorphan-quinidine
- Diamode
- Digox
- digoxin
- dorzolamide-timolol
- dorzolamide-timolol (PF)
- dronedarone
- Duragesic
- dutasteride-tamsulosin
- Dutoprol
- Endocet
- Endodan
- Epitol
- eplerenone
- Equetro
- everolimus
- ezetimibe-atorvastatin
- Fatigue Relief Complex
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Flomax
- Gengraf
- Heartburn Relief
- Hecoria
- ibuprofen-oxycodone
- Imodium Multi-symptom Relief
- Incivek
- Inderal La
- Inderal Xl
- Innopran Xl
- Inspra
- isoniazid-rifamp-pyrazinamide
- Istalol
- ivacaftor
- Jalyn
- Kalydeco
- ketoconazole
- labetalol
- Lanoxin
- Lanoxin Pediatric
- Latuda
- Lazanda
- Levitra
- Lipitor
- Liptruzet
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lopressor
- Lopressor Hct
- lurasidone
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Multaq
- Mycobutin
- nadolol
- nadolol-bendroflumethiazide
- nebivolol
- Neoral
- Nuedexta
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- pindolol
- Pletal
- Priftin
- Primlev
- Prograf
- propranolol
- propranolol-hydrochlorothiazid
- quinidine gluconate
- quinidine sulfate
- Rapamune
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Roxicet
- Sandimmune
- Sectral
- sirolimus
- Sorine
- sotalol
- Sotalol Af
- St. John's wort
- Stendra
- Sublimaze (pf)
- Subsys
- tacrolimus
- Tagamet Hb
- tamsulosin
- Tegretol
- Tegretol Xr
- telaprevir
- temsirolimus
- Tenoretic 100
- Tenoretic 50
- Tenormin
- timolol
- timolol maleate
- timolol maleate (PF)
- Timoptic
- Timoptic Ocudose (pf)
- Timoptic-xe
- Toprol Xl
- Torisel
- Tracleer
- Trandate
- Ultra A-d
- vardenafil
- Victrelis
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xartemis Xr
- Zortress
- Complete atrioventricular block
- Lown-ganong-levine syndrome
- Second degree atrioventricular heart block
- Severe hypotension
- Wolff-parkinson-white pattern
Contraindicated
- Acute decompensated heart failure
- Bradycardia
- Chronic idiopathic constipation
- Hypotension
- Myasthenia gravis
- Sick sinus syndrome
Severe
Moderate
- Asthma
- Disease of liver
- Kidney disease with reduction in GFR
DILTIAZEM 24HR ER (CD) (diltiazem HCl)
- Hypertension
- Prevention of anginal pain in coronary artery disease
- Peripheral edema
- Skin rash
- Fatigue
- Sinusitis
More Frequent
Severe
Less Severe
- Atrioventricular block
- Bradycardia
- Constipation
- Diarrhea
- Dizziness
- Dyspepsia
- Edema
- Flushing
- General weakness
- Headache disorder
- Insomnia
- Nausea
- Orthostatic hypotension
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Acute generalized exanthematous pustulosis
- Angioedema
- Asthma exacerbation
- Asystole
- Bronchospastic pulmonary disease
- Bundle branch block
- Chronic heart failure
- Dyspnea
- Erythema multiforme
- Exfoliative dermatitis
- Extrapyramidal disease
- Gingival hyperplasia
- Hemolytic anemia
- Hyperbilirubinemia
- Hypersensitivity angiitis
- Hyperuricemia
- Hypotension
- Leukopenia
- Myopathy
- Purpura
- Retinal disorder
- Stevens-johnson syndrome
- Tachycardia
- Thrombocytopenic disorder
- Toxic amblyopia
- Toxic epidermal necrolysis
- Ventricular premature beats
- Worsening of chronic heart failure
Less Severe
- Abnormal sexual function
- Acute abdominal pain
- Alopecia
- Anorexia
- Depression
- Dream disorder
- Drowsy
- Dysgeusia
- Epistaxis
- Gait abnormality
- Hallucinations
- Hyperglycemia
- Lichenoid dermatitis drug eruption
- Memory impairment
- Nasal congestion
- Nervousness
- Nocturia
- Palpitations
- Paresthesia
- Periorbital edema
- Personality disorders
- Petechiae
- Phototoxicity
- Polydipsia
- Polyuria
- Pruritus of skin
- Syncope
- Tinnitus
- Tremor
- Urticaria
- Vomiting
- Weight gain
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Diltiazem (Sust Action)
Safety and efficacy in pediatrics have not been established.
- 1 Day – 18 Years
- Safety and efficacy in pediatrics have not been established.
Diltiazem Hydrochloride
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Diltiazem Hydrochloride
None
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Diltiazem
Renal-Half-life may be increased. Follow blood pressure closely. Monitor renal function periodically. Gastrointestinal-May exacerbate pre-existing or cause constipation. Cardiovascular-May cause fluid retention, peripheral edema and/or exacerbate heart failure. Hepatic-Monitor liver function periodically.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Prevention of anginal pain in coronary artery disease | |
| I20 | Angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| I20 | Angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
Formulary Reference Tool