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Drug overview for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
Generic name: green tea leaf extract/theanine/elderberry fruit/olive xtrac
Drug class:
Therapeutic class: Alternative Therapy
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: green tea leaf extract/theanine/elderberry fruit/olive xtrac
Drug class:
Therapeutic class: Alternative Therapy
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac) have been approved by the FDA:
Indications:
None.
Professional Synonyms:
None.
Indications:
None.
Professional Synonyms:
None.
The following dosing information is available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
There are 0 contraindications.
There are 1 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Vincristine/P-glycoprotein (P-gp) Inducers SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Inducers of P-glycoprotein (P-gp) may reduce systemic exposure to vincristine.(1) CLINICAL EFFECTS: Concurrent or recent use of P-gp inducers may result in decreased effectiveness of vincristine.(1) PREDISPOSING FACTORS: Induction effects may be more likely with regular use of the inducer for longer than 1-2 weeks. PATIENT MANAGEMENT: The US manufacturer of vincristine states that concurrent use of P-gp inducers should be avoided.(1) Consider the use of agents with no or minimal induction potential if possible. Monitor patients for decreased response to therapy. DISCUSSION: Vincristine is transported by P-gp and inducers of this transporter are expected to decrease levels of vincristine.(1) Inducers of P-gp include linked to this monograph include: efavirenz, green tea, and lorlatinib.(2,3) |
VINCASAR PFS, VINCRISTINE SULFATE |
There are 2 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Nadolol/Green Tea SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Nadolol is a substrate of OATP1A2, an influx transporter found in intestinal epithelium. Green tea catechins inhibit several drug transporters, including OATP1A2, leading to decreased absorption of nadolol. P-glycoprotein may also be involved, however no studies have confirmed its role. CLINICAL EFFECTS: Concomitant use of nadolol with green tea or green tea catechins may decrease the effectiveness of nadolol.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Advise patients maintained on nadolol to avoid green tea and green tea supplements. DISCUSSION: In a randomized crossover study in 10 healthy subjects, concurrent use of nadolol (30 mg daily) and green tea (700 mL/day), decreased the maximum concentration (Cmax) and area-under-curve (AUC) of nadolol by 85.3% and 85%, respectively. Pharmacodynamic parameters assessed included pulse rate, systolic blood pressure, and diastolic blood pressure. Although all parameters were affected slightly, nadolol's systolic blood pressure lowering effect was significantly suppressed (p = 0.042).(1) |
CORGARD, NADOLOL |
| Migalastat/Caffeine-Containing Products SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: The mechanism of this interaction is unknown. CLINICAL EFFECTS: Concurrent use of a caffeine-containing product may result in decreased levels and effectiveness of migalastat.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Avoid coadministration of migalastat with caffeine-containing products. Do not administer caffeine-containing products within 2 hours before and 2 hours after taking migalastat.(1) DISCUSSION: Coadministration of migalastat with caffeine 190 mg decreased the migalastat maximum concentration (Cmax) by 60% and area-under-curve (AUC) by 55%.(1) |
GALAFOLD |
The following contraindication information is available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 0 contraindications.
There are 1 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Insomnia |
There are 3 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Anxiety disorder |
| Disease of liver |
| Hypertension |
The following adverse reaction information is available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 1 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Severe diarrhea |
There are 7 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Diarrhea |
| Rare/Very Rare |
|---|
|
Dizziness Fatigue General weakness Nausea Stupor Vomiting |
The following precautions are available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for OLIVDEFENSE (green tea leaf extract/theanine/elderberry fruit/olive xtrac)'s list of indications:
No ICD codes found for this drug.
No ICD codes found for this drug.
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