PRISTIQ (DESVENLAFAXINE SUCCINATE)
- Major depressive disorder
- Pristiq Tablet,extended Release
- Desvenlafaxine Succinate Er Tablet,extended Release 24 Hr
- By Indication
100 mg tablet,extended release
- 1 tablet (100 mg) by oral route once daily
25 mg tablet,extended release
- 2 tablets (50 mg) by oral route once daily at approximately the same time each day
50 mg tablet,extended release
- 1 tablet (50 mg) by oral route once daily
100 mg tablet,extended release 24 hr
- 1 tablet (100 mg) by oral route once daily
25 mg tablet,extended release 24 hr
- 2 tablets (50 mg) by oral route once daily at approximately the same time each day
50 mg tablet,extended release 24 hr
- 1 tablet (50 mg) by oral route once daily
Major depressive disorder
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily at approximately the same time each day
- 1 tablet (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (200 mg) by oral route once daily
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Coumadin
- Demerol
- Demerol (pf)
- Jantoven
- meperidine
- meperidine (PF)
- Meperitab
- metoclopramide HCl
- Metozolv Odt
- Reglan
- warfarin
Severe
Moderate
- abciximab
- Abstral
- Actiq
- Activase
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Adderall
- Adderall Xr
- Adipex-p
- Adult Low Dose Aspirin
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aggrastat In Sodium Chloride
- Aggrenox
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- almotriptan malate
- Alsuma
- alteplase
- Amerge
- Amphetamine Salt Combo
- Anacin
- Anacin Maximum Strength
- Analgesic
- Anaprox
- Anaprox Ds
- Ansaid
- Antacid & Pain Relief
- Arthri-flex
- Arthrotec 50
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-81
- Aspir-low
- Aspir-trin
- aspirin
- Aspirin Childrens
- Aspirin Low Dose
- Aspirin Low-strength
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-calcium carbonate
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Axert
- Back & Body Pain Reliever
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Chewable Aspirin
- Bayer Childrens Aspirin
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Brilinta
- Buffered Aspirin
- Bufferin
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- Caldolor
- Cambia
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- Cataflam
- Celebrex
- celecoxib
- Child Aspirin
- Child Ibuprofen
- Children's Advil
- Children's Aspirin
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-DM-aspirin
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- chlorphenir-phenylephrn-aspirn
- cilostazol
- clopidogrel
- codeine-butalbital-ASA-caff
- Cold & Sinus Pain Relief
- Cold Relief
- Cold Relief Plus
- Cold-sinus Relief
- Conzip
- Daypro
- Desoxyn
- Dexedrine Spansule
- dextroamphetamine
- dextroamphetamine-amphetamine
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- dihydrocodeine-aspirin-caff
- dipyridamole-aspirin
- doxylamine-phenylep-DM-aspirin
- Duexis
- Duragesic
- E.c. Prin
- Ec-naprosyn
- Ecotrin
- Ecotrin Low Strength
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- eletriptan HBr
- Endodan
- Enteric Coated Aspirin
- eptifibatide
- etodolac
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Feldene
- fenoprofen
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Fiorinal
- Fiorinal-codeine #3
- Flanax
- Flector
- flurbiprofen
- Frova
- frovatriptan
- gluc-msm-coll2-hyal-antiarthr3
- glucos-msm-C-Mn-ginger-willow
- glucos-msm-C-Mn-herb#21
- glucos-msm-collagen-C-Mn-hrb21
- Glucosamine-msm Complex
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Imitrex
- Imitrex Statdose Kit Refill
- Imitrex Statdose Pen
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- ketoprofen
- ketorolac
- Lazanda
- Levacet
- levmetamfetamine
- lisdexamfetamine
- Lite Coat Aspirin
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-dose Aspirin
- Maxalt
- Maxalt-mlt
- Medi-profen
- Medi-seltzer
- Mediproxen
- mefenamic acid
- meloxicam
- methamphetamine
- Midol (naproxen)
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- Mobic
- Motrin Ib
- Motrin Pm
- Msm Glucosamine Complex
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- naratriptan
- Neoprofen (ibuprofen Lysn)(pf)
- Nucynta
- Nucynta Er
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxaprozin
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Pennsaid
- Percodan
- phentermine
- phentermine-topiramate
- piroxicam
- Plavix
- Pletal
- Ponstel
- Procentra
- Provil
- pseudoephedrine-ibuprofen
- Qsymia
- Relpax
- Reopro
- Reprexain
- Retavase
- reteplase
- rizatriptan
- Sinus & Cold-d
- Solaraze
- Sprix
- St Joseph Aspirin
- St. Joseph Aspirin
- Sublimaze (pf)
- Subsys
- sulindac
- sumatriptan
- sumatriptan succinate
- Sumavel Dosepro
- Super Pain Relief
- Suprenza
- Synalgos-dc
- Synapryn
- tapentadol
- tenecteplase
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- Tnkase
- tolmetin
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Tri-buffered Aspirin
- Ultracet
- Ultram
- Ultram Er
- Vanquish
- Vapor Inhaler
- Vicoprofen
- Vimovo
- Voltaren-xr
- Vyvanse
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Women's Aspirin With Calcium
- Zenzedi
- Zipsor
- zolmitriptan
- Zomig
- Zomig Zmt
- Zorvolex
- Neuroleptic malignant syndrome
- Serotonin syndrome
Contraindicated
- Angle-closure glaucoma
- Bipolar disorder
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Disease of liver
- Hemorrhage
- Hypertension
- Hypomania
- Interstitial lung disease
- Risk of angle-closure glaucoma due to narrow angle
- Suicidal ideation
Severe
Moderate
- 30 day risk period post-myocardial infarction
- Cerebrovascular disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Hyponatremia
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Manic disorder
- Seizure disorder
- SIADH syndrome
PRISTIQ (DESVENLAFAXINE SUCCINATE)
- Major depressive disorder
- Accommodation disorder
- Headache disorder
- Anorexia
- Blurred vision
- Constipation
- Disorder of ejaculation
- Dizziness
- Drowsy
- Dysgeusia
- Erectile dysfunction
- General weakness
- Hyperhidrosis
- Insomnia
- Nausea
- Nervousness
- Paresthesia
- Symptoms of anxiety
- Tremor
- Visual changes
- Vomiting
- Xerostomia
More Frequent
Severe
Less Severe
- Abnormal sexual function
- Akathisia
- Chest pain
- Hypercholesterolemia
- Hypertension
- Increased urinary frequency
- Pruritus of skin
- Tachycardia
- Urinary retention
- Acute confusion
- Agitation
- Bronchitis
- Chills
- Diarrhea
- Dream disorder
- Dyspepsia
- Edema
- Flatulence
- Hostility
- Irritability
- Libido changes
- Migraine
- Neck pain
- Orgasm disorder
- Skin rash
- Tinnitus
- Twitching
- Vaginitis
- Vertigo
- Weight gain
- Weight loss
- Yawning
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Acquired dystonia
- Agranulocytosis
- Altered mental status
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Dyspnea
- Dysuria
- Eosinophilic pneumonia
- Erythema multiforme
- Extrapyramidal disease
- Gastrointestinal hemorrhage
- Hepatitis
- Hypoglycemic disorder
- Hyponatremia
- Increased risk of bleeding
- Interstitial pneumonitis
- Manic disorder
- Mood changes
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Ocular hypertension
- Orthostatic hypotension
- Pancreatitis
- Peripheral edema
- Prolonged QT interval
- Rhabdomyolysis
- Secondary angle-closure glaucoma
- Seizure disorder
- Serotonin syndrome
- SIADH syndrome
- Stevens-johnson syndrome
- Suicidal ideation
- Takotsubo cardiomyopathy
- Tardive dyskinesia
- Thrombocytopenic disorder
- Torsades de pointes
- Toxic epidermal necrolysis
- Ventricular fibrillation
Less Severe
- Abnormal hepatic function tests
- Abnormal vaginal bleeding
- Acute abdominal pain
- Alopecia
- Ataxia
- Bruxism
- Delirium
- Depersonalization
- Dysmenorrhea
- Ecchymosis
- Epistaxis
- Eructation
- Flu-like symptoms
- Flushing
- Hemorrhage
- Hyperacusis
- Hyperprolactinemia
- Hypertonia
- Hypomania
- Menorrhagia
- Muscle rigidity
- Mydriasis
- Palpitations
- Proteinuria
- Rhinitis
- Sinusitis
- Skin photosensitivity
- Trismus
- Urticaria
- Vasodilation of blood vessels
Contraindicated
None
Severe Precaution
Desvenlafaxine
Possible increased suicidal ideation and attempt, weight loss, No established safety and efficacy for major depressive disorder. Not indicated for use in pediatric patients.
- 1 Day – 18 Years
- Possible increased suicidal ideation and attempt, weight loss, No established safety and efficacy for major depressive disorder. Not indicated for use in pediatric patients.
Management or Monitoring Precaution
None
Desvenlafaxine
- Severity Level:
2
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Desvenlafaxine
No known infant adv effects with short term tx, long term cns effects unknown
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | No known infant adv effects with short term tx, long term cns effects unknown |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Desvenlafaxine
Renal-Recommended dose of 50mg for CrCL=30-50 mL/minute. Endocrine-May exacerbate or cause SIADH or hyponatremia. Monitor sodium level closely when starting or changing dosages in older adults. Cardiovascular-Elderly may be at increased risk for orthostatic hypotension, syncope and falls.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
Major depressive disorder | |
F32 | Major depressive disorder, single episode |
F32.0 | Major depressive disorder, single episode, mild |
F32.1 | Major depressive disorder, single episode, moderate |
F32.2 | Major depressive disorder, single episode, severe without psychotic features |
F32.3 | Major depressive disorder, single episode, severe with psychotic features |
F32.4 | Major depressive disorder, single episode, in partial remission |
F32.5 | Major depressive disorder, single episode, in full remission |
F32.9 | Major depressive disorder, single episode, unspecified |
F33 | Major depressive disorder, recurrent |
F33.0 | Major depressive disorder, recurrent, mild |
F33.1 | Major depressive disorder, recurrent, moderate |
F33.2 | Major depressive disorder, recurrent severe without psychotic features |
F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
F33.4 | Major depressive disorder, recurrent, in remission |
F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
F33.41 | Major depressive disorder, recurrent, in partial remission |
F33.42 | Major depressive disorder, recurrent, in full remission |
F33.9 | Major depressive disorder, recurrent, unspecified |
0-9 | A-Z |
---|---|
F32 | Major depressive disorder, single episode |
F32.0 | Major depressive disorder, single episode, mild |
F32.1 | Major depressive disorder, single episode, moderate |
F32.2 | Major depressive disorder, single episode, severe without psychotic features |
F32.3 | Major depressive disorder, single episode, severe with psychotic features |
F32.4 | Major depressive disorder, single episode, in partial remission |
F32.5 | Major depressive disorder, single episode, in full remission |
F32.9 | Major depressive disorder, single episode, unspecified |
F33 | Major depressive disorder, recurrent |
F33.0 | Major depressive disorder, recurrent, mild |
F33.1 | Major depressive disorder, recurrent, moderate |
F33.2 | Major depressive disorder, recurrent severe without psychotic features |
F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
F33.4 | Major depressive disorder, recurrent, in remission |
F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
F33.41 | Major depressive disorder, recurrent, in partial remission |
F33.42 | Major depressive disorder, recurrent, in full remission |
F33.9 | Major depressive disorder, recurrent, unspecified |