DUAVEE (ESTROGENS, CONJUGATED/BAZEDOXIFENE ACETATE)
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
0.45 mg-20 mg tablet
- 1 tablet by oral route once daily
Post-menopausal osteoporosis prevention
- 1 tablet by oral route once daily
Vasomotor symptoms associated with menopause
- 1 tablet by oral route once daily
- anastrozole
- Arimidex
- Aromasin
- Cyklokapron
- exemestane
- Femara
- letrozole
- Lysteda
- tranexamic acid
Contraindicated
- None
Severe
Moderate
- A-hydrocort
- A-methapred
- Alagesic Lq
- amobarbital
- Amytal
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Ascomp With Codeine
- Belladonna-phenobarbital
- betamethasone acet & sod phos
- Bivigam
- Brevital
- budesonide
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Capacet
- Carimune Nf Nanofiltered
- Celestone Soluspan
- Cerebyx
- codeine-butalbital-ASA-caff
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Dutoprol
- Entocort Ec
- Esgic
- ethotoin
- Evista
- Ez Use Joint-tunnel-trigger
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- First-duke's
- First-mary's Mouthwash
- Flebogamma Dif
- Flo-pred
- fludrocortisone
- fosphenytoin
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- Hizentra
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Kenalog
- Lopressor
- Lopressor Hct
- Luminal
- Margesic
- Marten-tab
- Medrol
- Medrol (pak)
- methohexital
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Millipred
- Millipred Dp
- Mysoline
- Nembutal Sodium
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- Orapred
- Orapred Odt
- Pediapred
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- primidone
- Privigen
- Proctocort
- raloxifene
- Rayos
- Rectacort-hc
- secobarbital sodium
- Seconal Sodium
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Tencon
- Toprol Xl
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Uceris
- Veripred 20
- Zebutal
- Acute myocardial infarction
- Antithrombin III deficiency
- Carcinoma of breast
- Cerebrovascular accident
- Deep venous thrombosis
- Disease of liver
- Estrogen-dependent neoplasm
- Lactating mother
- Predisposition to thrombosis
- Pregnancy
- Protein C deficiency disease
- Pulmonary thromboembolism
- Severe uncontrolled hypertension
- Thromboembolic disorder
- Thrombophilia
Contraindicated
- Coronary artery disease
- Dementia
- Endometrial carcinoma
- Family history of malignant tumor of breast
- Hereditary angioedema
- Hypercalcemia
- Increased cardiovascular event risk
- Malignant neoplasm of the ovary
- Retinal thrombosis
- Tobacco smoker
Severe
Moderate
- Asthma
- Chloasma
- Diabetes mellitus
- Edema
- Gallbladder disease
- Hepatic porphyria
- Hypercholesterolemia
- Hypertension
- Hypertriglyceridemia
- Hypoparathyroidism
- Hypothyroidism
- Mammography abnormal
- Migraine
- Obesity
- Seizure disorder
- Systemic lupus erythematosus
- Unspecified lump in breast
- Uterine leiomyoma
DUAVEE (ESTROGENS, CONJUGATED/BAZEDOXIFENE ACETATE)
- Post-menopausal osteoporosis prevention
- Vasomotor symptoms associated with menopause
- Gynecomastia
- Mastalgia
- Abdominal distension
- Acute abdominal pain
- Headache disorder
More Frequent
Severe
Less Severe
- Back pain
- Gastroenteritis
- Weight gain
- Arthralgias
- Body fluid retention
- Candidiasis
- Constipation
- Cramps in legs
- Diarrhea
- Dizziness
- Dysmenorrhea
- Flatulence
- General weakness
- Increased appetite
- Insomnia
- Migraine
- Myalgias
- Nausea
- Peripheral edema
- Symptoms of anxiety
- Vaginal discharge
- Vaginitis
- Vulvovaginal candidiasis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal vaginal bleeding
- Acute myocardial infarction
- Acute pancreatitis
- Amenorrhea
- Anaphylaxis
- Angioedema
- Asthma exacerbation
- Cerebrovascular accident
- Dementia
- Depression
- Endometrial carcinoma
- Endometrial hyperplasia
- Erythema multiforme
- Erythema nodosum
- Gallbladder obstruction
- Hepatitis
- Hypertension
- Hypotension
- Influenza
- Involuntary muscle movement
- Ischemic colitis
- Lower seizure threshold
- Malignant neoplasm of the ovary
- Menorrhagia
- Neoplasm of breast
- Nipple discharge
- Pulmonary thromboembolism
- Retinal thrombosis
- Skin rash
- Thromboembolic disorder
- Thrombophlebitis
- Unspecified lump in breast
- Upper respiratory infection
- Urticaria
- Uterine leiomyoma
- Venous thrombosis
Less Severe
- Alopecia
- Chloasma
- Hirsutism
- Hypertriglyceridemia
- Keratoconus
- Libido changes
- Mood changes
- Nervousness
- Pelvic pain
- Pruritus of skin
- Vomiting
- Weight loss
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Estrogens, Conjugated
May cause premature epiphyseal closure. Limited information for inducing puberty. Monitor growth in patient with bone immaturity.
- 1 Day – 18 Years
- May cause premature epiphyseal closure. Limited information for inducing puberty. Monitor growth in patient with bone immaturity.
Estrogens, Conjugated-bazedoxifene
- Severity Level:
X
- Additional Notes:
Contraindicated
Estrogens, Conjugated-bazedoxifene
Contraindicated in lactation per manufacturer
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Contraindicated in lactation per manufacturer |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Estrogenic Agents (systemic)
General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Cardiovascular-May increase risk for thromboembolic events. Avoid use in patients with known, suspected, or history of arterial or venous thromboembolic disease. Neuro/Psych-May increase the risk for dementia. Genitourinary-May aggravate urinary incontinence.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Women taking this product should not take additional estrogens, progestins, or additional estrogen agonist/antagonists (see also Drug Interactions section). Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor.<br /><br />Estrogens should not be used to prevent heart disease or dementia. Estrogens can increase the risk of cancer of the uterus (endometrial cancer). The bazedoxifene in this product may help decrease this risk.<br /><br />Tell your doctor right away if you have any unusual vaginal bleeding. In postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. Estrogens alone do not appear to increase the risk of breast cancer when used for up to 7 years.<br /><br />Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries. The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time.<br /><br />Discuss the use of this medication with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take this medication. If you will be taking this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.
Post-menopausal osteoporosis prevention | |
Z78.0 | Asymptomatic menopausal state |
Vasomotor symptoms associated with menopause | |
N95.1 | Menopausal and female climacteric states |
N95.9 | Unspecified menopausal and perimenopausal disorder |
0-9 | A-Z |
---|---|
N95.1 | Menopausal and female climacteric states |
N95.9 | Unspecified menopausal and perimenopausal disorder |
Z78.0 | Asymptomatic menopausal state |