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ZONTIVITY (vorapaxar sulfate)
- blood clot prevention following PCI
- myocardial reinfarction prevention
- prevention for a blood clot going to the brain
- treatment to prevent peripheral artery thromboembolism
2.08 mg tablet
- 1 tablet (2.08 mg) by oral route once daily
Cerebral thromboembolism prevention
- 1 tablet (2.08 mg) by oral route once daily
Myocardial reinfarction prevention
- 1 tablet (2.08 mg) by oral route once daily
Peripheral arterial thromboembolism prevention
- 1 tablet (2.08 mg) by oral route once daily
Thrombosis prevention after PCI
- 1 tablet (2.08 mg) by oral route once daily
- Mifeprex
- mifepristone
Contraindicated
- apixaban
- Aptivus
- Belladonna-phenobarbital
- carbamazepine
- Carbatrol
- Cerebyx
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Eliquis
- Epitol
- Equetro
- fosphenytoin
- isoniazid-rifamp-pyrazinamide
- Luminal
- Mysoline
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- primidone
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- rivaroxaban
- Tegretol
- Tegretol Xr
- tipranavir
- Xarelto
Severe
Moderate
- Activase
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- alteplase
- Anaprox
- Anaprox Ds
- Ansaid
- Arixtra
- Arthrotec 50
- Brintellix
- Brisdelle
- Caldolor
- Cambia
- Cataflam
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- citalopram
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Coumadin
- Cymbalta
- dalteparin (porcine)
- Daypro
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Duexis
- duloxetine
- Ec-naprosyn
- Effexor Xr
- Elmiron
- enoxaparin
- eptifibatide
- escitalopram oxalate
- etodolac
- Feldene
- fenoprofen
- Fetzima
- Flanax
- Flector
- fluoxetine
- flurbiprofen
- fluvoxamine
- fondaparinux
- Fragmin
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- Jantoven
- ketoprofen
- ketorolac
- Khedezla
- lepirudin
- levomilnacipran
- Lexapro
- Lovenox
- Luvox Cr
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- milnacipran
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- olanzapine-fluoxetine
- oxaprozin
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pennsaid
- pentosan polysulfate sodium
- Pexeva
- piroxicam
- Ponstel
- Pristiq
- Provil
- Prozac
- Prozac Weekly
- pseudoephedrine-ibuprofen
- Refludan
- Reprexain
- Retavase
- reteplase
- Sarafem
- Savella
- sertraline
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- Symbyax
- tenecteplase
- Tnkase
- tolmetin
- venlafaxine
- Vicoprofen
- Viibryd
- vilazodone
- Vimovo
- Voltaren-xr
- vortioxetine
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- warfarin
- Zipsor
- Zoloft
- Zorvolex
- Cerebral amyloid angiopathy
- Cerebrovascular accident
- Hemorrhage
- Intracranial bleeding
- Transient cerebral ischemia
Contraindicated
- Increased risk of bleeding due to coagulation disorder
- Pregnancy
- Severe hepatic disease
Severe
Moderate
- None
ZONTIVITY (vorapaxar sulfate)
- blood clot prevention following PCI
- myocardial reinfarction prevention
- prevention for a blood clot going to the brain
- treatment to prevent peripheral artery thromboembolism
- Hemorrhage
- None
More Frequent
Severe
Less Severe
- Gastrointestinal hemorrhage
- Retinal disorder
- Anemia
- Depression
- Diplopia
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Intracranial bleeding
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Vorapaxar
No safety and efficacy established.
- 1 Day – 18 Years
- No safety and efficacy established.
Vorapaxar
- Severity Level:
D
- Additional Notes: Potential for serious adverse reactions(hemorrhage/maternal bleeding)
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Vorapaxar
Insuff human data
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff human data |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Vorapaxar
General-The elderly may be at higher risk for spontaneous hemorrhage.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- Vorapaxar increases the risk of bleeding, which may include bleeding in the brain and other serious (possibly fatal) bleeding problems. Do not use vorapaxar if you have had a stroke, mini-stroke (transient ischemic attack - TIA), or bleeding in the brain in the past; or if you have any current bleeding problems. Discuss the benefits and risks of this medication with your doctor.
Cerebral thromboembolism prevention | |
Z86.73 | Personal history of transient ischemic attack (TIa), and cerebral infarction without residual deficits |
Myocardial reinfarction prevention | |
I21 | Acute myocardial infarction |
I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
I21.9 | Acute myocardial infarction, unspecified |
I21.A | Other type of myocardial infarction |
I21.A1 | Myocardial infarction type 2 |
I21.A9 | Other myocardial infarction type |
I21.B | Myocardial infarction with coronary microvascular dysfunction |
I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
I25.2 | Old myocardial infarction |
I25.85 | Chronic coronary microvascular dysfunction |
Thrombosis prevention after PCI | |
Z98.61 | Coronary angioplasty status |
0-9 | A-Z |
---|---|
I21 | Acute myocardial infarction |
I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
I21.9 | Acute myocardial infarction, unspecified |
I21.A | Other type of myocardial infarction |
I21.A1 | Myocardial infarction type 2 |
I21.A9 | Other myocardial infarction type |
I21.B | Myocardial infarction with coronary microvascular dysfunction |
I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
I25.2 | Old myocardial infarction |
I25.85 | Chronic coronary microvascular dysfunction |
Z86.73 | Personal history of transient ischemic attack (TIa), and cerebral infarction without residual deficits |
Z98.61 | Coronary angioplasty status |
Formulary Reference Tool