DOCETAXEL (docetaxel)

There are 4 contraindications. Absolute contraindication.

Contraindication List
Hyperbilirubinemia
Interstitial lung disease
Lactation
Severe infection

There are 17 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Anemia
Ascites
Cystoid macular edema
Diarrhea
Disease of liver
Edema
Left ventricular failure
Neutropenic disorder
Pericardial tamponade
Peripheral edema
Peripheral motor neuropathy
Peripheral neuropathy
Pleural effusions
Pregnancy
Pulmonary edema
Stomatitis
Thrombocytopenic disorder

There are 0 moderate contraindications.

There are 72 severe adverse reactions.

More Frequent	Less Frequent
Alopecia Anemia Hypersensitivity drug reaction Infection Leukopenia Neutropenic disorder Peripheral sensory neuropathy Pharyngitis Thrombocytopenic disorder	Abnormal hepatic function tests Esophagitis Flushing Hyperbilirubinemia Hypotension Increased alanine transaminase Increased aspartate transaminase Palmar-plantar erythrodysesthesia Severe erythema Urticaria

Rare/Very Rare

Abnormal ECG Acute generalized exanthematous pustulosis Acute myeloid leukemia Acute myocardial infarction Acute pulmonary edema Acute respiratory distress syndrome Acute respiratory failure Anaphylaxis Atrial fibrillation Atrial flutter Bronchospastic pulmonary disease Cardiac arrhythmia Cystoid macular edema Deep venous thrombosis Dehydration Disseminated intravascular coagulation Enterocolitis Erythema multiforme Gastrointestinal obstruction Hearing loss Heart failure Hemorrhage Hepatitis Hypertension Hypokalemia Hypomagnesemia Hyponatremia Ileus Interstitial lung disease Interstitial pneumonitis Intestinal perforation Ischemic colitis Kidney disease with reduction in glomerular filtration rate (GFr) Lupus-like syndrome Myelodysplastic syndrome Myositis Neutropenic colitis Non-hodgkin's lymphoma Ototoxicity Phlebitis after infusion Pneumonia Pseudoscleroderma Pulmonary fibrosis Pulmonary thromboembolism Radiation recall syndrome Renal cell carcinoma Renal failure Seizure disorder Severe hypotension Stevens-johnson syndrome Toxic epidermal necrolysis Tumor lysis syndrome Unstable angina pectoris

There are 48 less severe adverse reactions.

More Frequent	Less Frequent
Abnormal desquamation Amenorrhea Anorexia Body fluid retention Constipation Cough Diarrhea Dysgeusia Dyspnea Erythema Fatigue Fever General weakness Myalgia Nail disorders Nausea Pain Paresthesia Skin rash Stomatitis Vasodilation of blood vessels Vomiting	Abdominal pain with cramps Arthralgia Back pain Conjunctivitis Dizziness Dysphagia Epistaxis Eye tearing Injection site sequelae Ocular redness Peripheral motor neuropathy Pruritus of skin Skin swelling Weight gain

Rare/Very Rare
Acute cognitive impairment Chest pain Chest tightness Dysesthesia Lymphedema Nail discoloration Sinus tachycardia Subacute cutaneous lupus erythematosus Syncope Tachycardia Thrombophlebitis Visual changes

Docetaxel may cause fetal harm when administered to pregnant women, but potential benefits may be acceptable in certain conditions despite possible risks to the fetus. Reproduction studies in rats and rabbits given docetaxel doses greater than or equal to 0.3 and 0.03

mg/kg (about 1/50 and 1/300 the maximum daily recommended human dose on a mg/m2 basis), respectively, during organogenesis revealed evidence of maternal toxicity, embryotoxicity, and fetotoxicity; fetotoxicity was characterized by intrauterine mortality, increased resorption, reduced fetal weight, and fetal ossification delay. There are no adequate and well-controlled studies to date using docetaxel in pregnant women. Docetaxel should be used during pregnancy only in life-threatening situations or in diseases for which safer drugs cannot be used or are ineffective.

Women of childbearing potential should be advised to avoid becoming pregnant during therapy with docetaxel. When docetaxel is used during pregnancy or if the patient becomes pregnant while receiving the drug, the patient should be apprised of the potential hazard to the fetus.

It is not known whether docetaxel is distributed into milk. Because of the potential for serious adverse reactions to docetaxel in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.

No enhanced Geriatric Use information available for this drug.