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SULFASALAZINE (SULFASALAZINE)
- Ulcerative colitis
- Ulcerative colitis remission
500 mg tablet
- 1 tablet (500 mg) by oral route 4 times per day after meals
500 mg tablet
- 1 tablet (500 mg) by oral route 4 times per day after meals
Rheumatoid arthritis
- 1 tablet (500 mg) by oral route 4 times per day after meals
Ulcerative colitis
- 1 tablet (500 mg) by oral route 4 times per day after meals
Ulcerative colitis remission
- 1 tablet (500 mg) by oral route 4 times per day after meals
- Hiprex
- methen-sod phos-meth blue-hyos
- methenamine hippurate
- methenamine mand-sod biphos
- methenamine mandelate
- typhoid vaccine
- Urogesic-blue
- Uroqid-acid No.2
- Uryl
- Vivotif Berna Vaccine
Contraindicated
- clozapine
- Clozaril
- Coumadin
- cyclosporine
- cyclosporine modified
- deferiprone
- Fazaclo
- Ferriprox
- Gengraf
- Jantoven
- Neoral
- Sandimmune
- Versacloz
- warfarin
Severe
Moderate
- Bio-35
- Bio-35, Gluten Free
- Body, Hair, Skin & Nails
- glucosamine-chondr-mv antiox#5
- Maximum Daily Green
- multivit & min-FA-diet comb 19
- mv,Ca,ir,min-FA-lut-lyco-hc153
- mv,Ca,ir,Mn-FA-cho-gel-ino-PAB
- mv,iron,min-FA-dietary cmb.24
- mv-Ca-Mn-iron-FA-lut-ly-hb#175
- mv-iron-FA-Ca-beepoln-hb 101
- mv-iron-min-FA-ino-chol-PABA
- mv-mn-FA-lycopene-lut-#178herb
- Relamine
- Super Multiple
- Super Multiple - Low Iron
- Gastrointestinal obstruction
- Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
- Hemolytic anemia from PK and g6PD deficiencies
- Porphyria
- Urinary tract obstructive uropathy
Contraindicated
- Aplastic anemia
- Disease of liver
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Severe infection
Severe
Moderate
- Asthma
- N-acetyltransferase slow acetylator
SULFASALAZINE (SULFASALAZINE)
- Ulcerative colitis
- Ulcerative colitis remission
- Allergic dermatitis
- Drug fever
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Abdominal pain with cramps
- Anorexia
- Diarrhea
- Dizziness
- Dyschromia
- Dyspepsia
- Headache disorder
- Nausea
- Oligospermia
- Urine discoloration
- Vomiting
More Frequent
Severe
Less Severe
- Agranulocytosis
- Blood dyscrasias
- Cyanosis
- Hemolytic anemia
- Hepatitis
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Ulcerative colitis
- Leukopenia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Alveolitis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Enterocolitis
- Eosinophilia
- Eosinophilic pneumonia
- Exfoliative dermatitis
- Glucose-6-phosphate dehydrogenase deficiency anemia
- Hallucinations
- Hearing loss
- Hemolytic uremic syndrome
- Hepatic failure
- Hepatic necrosis
- Hepatocellular damage
- Hypoprothrombinemia
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Kidney stone
- Methemoglobinemia
- Myelitis
- Myelodysplastic syndrome
- Myocarditis
- Nephritis
- Nephrotic syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pancreatitis
- Pneumonia
- Rhabdomyolysis
- Sepsis
- Serum sickness
- Stevens-johnson syndrome
- Stomatitis
- Urticaria
Less Severe
- Alopecia
- Ataxia
- Crystalluria
- Drowsy
- Hematuria
- Insomnia
- Periorbital edema
- Peripheral neuropathy
- Proteinuria
- Purpura
- Urinary tract infection
- Vertigo
Contraindicated
Sulfasalazine
Not recommended in infants under 2 months. May cause kernicterus.
- 1 Day – 59 Days
- 1 Not recommended in infants under 2 months. May cause kernicterus.
Severe Precaution
None
Management or Monitoring Precaution
Sulfasalazine
No safety and efficacy age < 2 years.
- 60 Days – 2 Years
- No safety and efficacy age < 2 years.
Sulfasalazine
- Severity Level:
B
- Additional Notes: Case reports of neural tube defects. monitor newborn for possible kernicterus
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Sulfasalazine
Caution w/ g6Pd def; active metabolite excreted; monitor infant for diarrhea
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Caution w/ g6Pd def; active metabolite excreted; monitor infant for diarrhea |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Sulfasalazine
Renal: Elderly at increased risk of severe adverse reactions with decreased renal function. Metabolic: Slow acetylator status may predispose elderly to increased severe side effects.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Ulcerative colitis | |
| K51 | Ulcerative colitis |
| K51.0 | Ulcerative (chronic) pancolitis |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.01 | Ulcerative (chronic) pancolitis with complications |
| K51.011 | Ulcerative (chronic) pancolitis with rectal bleeding |
| K51.012 | Ulcerative (chronic) pancolitis with intestinal obstruction |
| K51.013 | Ulcerative (chronic) pancolitis with fistula |
| K51.014 | Ulcerative (chronic) pancolitis with abscess |
| K51.018 | Ulcerative (chronic) pancolitis with other complication |
| K51.019 | Ulcerative (chronic) pancolitis with unspecified complications |
| K51.2 | Ulcerative (chronic) proctitis |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.21 | Ulcerative (chronic) proctitis with complications |
| K51.211 | Ulcerative (chronic) proctitis with rectal bleeding |
| K51.212 | Ulcerative (chronic) proctitis with intestinal obstruction |
| K51.213 | Ulcerative (chronic) proctitis with fistula |
| K51.214 | Ulcerative (chronic) proctitis with abscess |
| K51.218 | Ulcerative (chronic) proctitis with other complication |
| K51.219 | Ulcerative (chronic) proctitis with unspecified complications |
| K51.3 | Ulcerative (chronic) rectosigmoiditis |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.31 | Ulcerative (chronic) rectosigmoiditis with complications |
| K51.311 | Ulcerative (chronic) rectosigmoiditis with rectal bleeding |
| K51.312 | Ulcerative (chronic) rectosigmoiditis with intestinal obstruction |
| K51.313 | Ulcerative (chronic) rectosigmoiditis with fistula |
| K51.314 | Ulcerative (chronic) rectosigmoiditis with abscess |
| K51.318 | Ulcerative (chronic) rectosigmoiditis with other complication |
| K51.319 | Ulcerative (chronic) rectosigmoiditis with unspecified complications |
| K51.5 | Left sided colitis |
| K51.50 | Left sided colitis without complications |
| K51.51 | Left sided colitis with complications |
| K51.511 | Left sided colitis with rectal bleeding |
| K51.512 | Left sided colitis with intestinal obstruction |
| K51.513 | Left sided colitis with fistula |
| K51.514 | Left sided colitis with abscess |
| K51.518 | Left sided colitis with other complication |
| K51.519 | Left sided colitis with unspecified complications |
| K51.8 | Other ulcerative colitis |
| K51.80 | Other ulcerative colitis without complications |
| K51.81 | Other ulcerative colitis with complications |
| K51.811 | Other ulcerative colitis with rectal bleeding |
| K51.812 | Other ulcerative colitis with intestinal obstruction |
| K51.813 | Other ulcerative colitis with fistula |
| K51.814 | Other ulcerative colitis with abscess |
| K51.818 | Other ulcerative colitis with other complication |
| K51.819 | Other ulcerative colitis with unspecified complications |
| K51.9 | Ulcerative colitis, unspecified |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.91 | Ulcerative colitis, unspecified, with complications |
| K51.911 | Ulcerative colitis, unspecified with rectal bleeding |
| K51.912 | Ulcerative colitis, unspecified with intestinal obstruction |
| K51.913 | Ulcerative colitis, unspecified with fistula |
| K51.914 | Ulcerative colitis, unspecified with abscess |
| K51.918 | Ulcerative colitis, unspecified with other complication |
| K51.919 | Ulcerative colitis, unspecified with unspecified complications |
| Ulcerative colitis remission | |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.40 | Inflammatory polyps of colon without complications |
| K51.50 | Left sided colitis without complications |
| K51.80 | Other ulcerative colitis without complications |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| 0-9 | A-Z |
|---|---|
| K51 | Ulcerative colitis |
| K51.0 | Ulcerative (chronic) pancolitis |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.01 | Ulcerative (chronic) pancolitis with complications |
| K51.011 | Ulcerative (chronic) pancolitis with rectal bleeding |
| K51.012 | Ulcerative (chronic) pancolitis with intestinal obstruction |
| K51.013 | Ulcerative (chronic) pancolitis with fistula |
| K51.014 | Ulcerative (chronic) pancolitis with abscess |
| K51.018 | Ulcerative (chronic) pancolitis with other complication |
| K51.019 | Ulcerative (chronic) pancolitis with unspecified complications |
| K51.2 | Ulcerative (chronic) proctitis |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.21 | Ulcerative (chronic) proctitis with complications |
| K51.211 | Ulcerative (chronic) proctitis with rectal bleeding |
| K51.212 | Ulcerative (chronic) proctitis with intestinal obstruction |
| K51.213 | Ulcerative (chronic) proctitis with fistula |
| K51.214 | Ulcerative (chronic) proctitis with abscess |
| K51.218 | Ulcerative (chronic) proctitis with other complication |
| K51.219 | Ulcerative (chronic) proctitis with unspecified complications |
| K51.3 | Ulcerative (chronic) rectosigmoiditis |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.31 | Ulcerative (chronic) rectosigmoiditis with complications |
| K51.311 | Ulcerative (chronic) rectosigmoiditis with rectal bleeding |
| K51.312 | Ulcerative (chronic) rectosigmoiditis with intestinal obstruction |
| K51.313 | Ulcerative (chronic) rectosigmoiditis with fistula |
| K51.314 | Ulcerative (chronic) rectosigmoiditis with abscess |
| K51.318 | Ulcerative (chronic) rectosigmoiditis with other complication |
| K51.319 | Ulcerative (chronic) rectosigmoiditis with unspecified complications |
| K51.40 | Inflammatory polyps of colon without complications |
| K51.5 | Left sided colitis |
| K51.50 | Left sided colitis without complications |
| K51.50 | Left sided colitis without complications |
| K51.51 | Left sided colitis with complications |
| K51.511 | Left sided colitis with rectal bleeding |
| K51.512 | Left sided colitis with intestinal obstruction |
| K51.513 | Left sided colitis with fistula |
| K51.514 | Left sided colitis with abscess |
| K51.518 | Left sided colitis with other complication |
| K51.519 | Left sided colitis with unspecified complications |
| K51.8 | Other ulcerative colitis |
| K51.80 | Other ulcerative colitis without complications |
| K51.80 | Other ulcerative colitis without complications |
| K51.81 | Other ulcerative colitis with complications |
| K51.811 | Other ulcerative colitis with rectal bleeding |
| K51.812 | Other ulcerative colitis with intestinal obstruction |
| K51.813 | Other ulcerative colitis with fistula |
| K51.814 | Other ulcerative colitis with abscess |
| K51.818 | Other ulcerative colitis with other complication |
| K51.819 | Other ulcerative colitis with unspecified complications |
| K51.9 | Ulcerative colitis, unspecified |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.91 | Ulcerative colitis, unspecified, with complications |
| K51.911 | Ulcerative colitis, unspecified with rectal bleeding |
| K51.912 | Ulcerative colitis, unspecified with intestinal obstruction |
| K51.913 | Ulcerative colitis, unspecified with fistula |
| K51.914 | Ulcerative colitis, unspecified with abscess |
| K51.918 | Ulcerative colitis, unspecified with other complication |
| K51.919 | Ulcerative colitis, unspecified with unspecified complications |
Formulary Reference Tool