NIACIN (niacin)

There are 2 contraindications. Absolute contraindication.

Contraindication List
Arterial hemorrhage
Disease of liver

There are 2 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Alcohol use disorder
Peptic ulcer

There are 6 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
30 day risk period post-myocardial infarction
Diabetes mellitus
Gout
Hypophosphatemia
Hypotension
Increased risk of bleeding due to coagulation disorder

There are 16 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Abnormal hepatic function tests Anaphylaxis Angioedema Atrial fibrillation Drug-induced hepatitis Dyspnea Edema Jaundice Laryngeal edema Laryngismus Macular retinal edema Myopathy Paresthesia Peptic ulcer Urticaria Vesicular rash

There are 39 less severe adverse reactions.

More Frequent	Less Frequent
Cough Diarrhea Dyspepsia Flushing Nausea Pruritus of skin Vomiting	Cardiac arrhythmia Dizziness Dry skin Exacerbation of peptic ulcer Hyperglycemia Hyperuricemia Hypophosphatemia Myalgia Syncope

Rare/Very Rare
Acquired acanthosis nigricans Blurred vision Chills Dyschromia Eructation Facial edema Flatulence General weakness Hyperhidrosis Hypoprothrombinemia Hypotension Insomnia Maculopapular rash Migraine Muscle weakness Nervousness Orthostatic hypotension Palpitations Peripheral edema Skin rash Stinging of skin Tachycardia Thrombocytopenic disorder

Administration of supplementary doses of niacin during pregnancy has not been associated with any adverse effects to the mother or fetus. However, toxicologic studies have not been performed with large doses of niacin, and large doses of the drug should not be used in women who are or may become pregnant unless the possible benefits outweigh the potential risks to the fetus.

Drug/Drug Class	Severity	Precaution Description	Pregnancy Category Description
Niacin (> 50 Mg)	2	Not rec for lipid lowering tx; assess risk benefit for triglyceride lowering tx	No fda rating but may have precautions or warnings; may have animal and/or human studies or pre or post marketing information.

Administration of supplementary doses of niacin during lactation has not been associated with any adverse effects to the mother or fetus.

Precaution Exists
Precaution exists. (No data or inconclusive human data.) Use of this drug by breast feeding mothers should be evaluated carefully.

Drug Name	Excretion Potential	Effect on Infant	Notes
Niacin	Excreted.This drug is known to be excreted in human breast milk.	It is not known whether this drug has an adverse effect on the nursing infant. (No data or inconclusive human data)	Potential adv effect on infant with lipid altering dose, mfg does not rec

No enhanced Geriatric Use information available for this drug.