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HEMORRHOIDAL CREAM (PHENYLEPHRINE/PRAMOXINE/GLYCERIN/WHITE PETROLATUM)
- Hemorrhoids
- Proctitis
- Pruritus ani
- Rectal pain
Maximum Strength 0.25 %-1 % rectal cream
- Dosage information is not available
0.25 %-1 % rectal
- Dosage information is not available
- Dosage information is not available
0.25 %-3 %-12 % cream
- Dosage information is not available
cream
- Dosage information is not available
Hemorrhoidal 0.25 %-3 %-12 % cream
- Dosage information is not available
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- Eldepryl
- linezolid
- rasagiline
- selegiline HCl
- Zelapar
- Zyvox
Severe
Moderate
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- None
Contraindicated
- Large open wound
Severe
Moderate
- Benign prostatic hyperplasia
- Cardiac arrhythmia
- Coronary artery disease
- Hypertension
- Hyperthyroidism
- Nervousness
HEMORRHOIDAL CREAM (PHENYLEPHRINE/PRAMOXINE/GLYCERIN/WHITE PETROLATUM)
- Hemorrhoids
- Proctitis
- Pruritus ani
- Rectal pain
- None
- None
More Frequent
Severe
Less Severe
- Angioedema
- Dermatitis due to topical drug
- Erythema
- Pruritus of skin
- Skin rash
- Stinging of skin
- Urticaria
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Anaphylaxis
- Bradycardia
- Cardiac arrhythmia
- CNS toxicity
- Cyanosis
- Dizziness
- Drowsy
- Eyelid edema
- Headache disorder
- Hyperhidrosis
- Hypotension
- Insomnia
- Methemoglobinemia
- Nervousness
- Pallor
- Respiratory depression
- Seizure disorder
- Tachycardia
- Tremor
- Unconsciousness
Less Severe
- Acute confusion
- Apprehension
- Blurred vision
- Dizziness
- Edema
- Euphoria
- Nervousness
- Rectal irritation
- Sensation of cold
- Sensation of warmth
- Tinnitus
- Twitching
- Vomiting
Contraindicated
Phenylephrine (Oral,Rectal)
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
Severe Precaution
None
Management or Monitoring Precaution
Pramoxine
Pediatrics are more sensitive to toxic effects.
- 1 Day – 12 Years
- Pediatrics are more sensitive to toxic effects.
Phenylephrine
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Pramoxine
- Severity Level:
C
- Additional Notes: Insufficient human data
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Phenylephrine
Oral bioavailability low; infant exposure may be minimal
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Oral bioavailability low; infant exposure may be minimal |
No Known Risk
Glycerin (as Emollient)
None
Per briggs, unlikely that significant amounts would be excreted in milk
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | None |
Pramoxine
None
Per briggs, unlikely that significant amounts would be excreted in milk
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Per briggs, unlikely that significant amounts would be excreted in milk |
Contraindicated
None
Precaution Exists
Phenylephrine
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Hemorrhoids | |
| K64.0 | First degree hemorrhoids |
| K64.8 | Other hemorrhoids |
| K64.9 | Unspecified hemorrhoids |
| O22.4 | Hemorrhoids in pregnancy |
| O22.40 | Hemorrhoids in pregnancy, unspecified trimester |
| O22.41 | Hemorrhoids in pregnancy, first trimester |
| O22.42 | Hemorrhoids in pregnancy, second trimester |
| O22.43 | Hemorrhoids in pregnancy, third trimester |
| O87.2 | Hemorrhoids in the puerperium |
| Proctitis | |
| K62.7 | Radiation proctitis |
| K62.89 | Other specified diseases of anus and rectum |
| Pruritus ani | |
| L29.0 | Pruritus ani |
| L29.3 | Anogenital pruritus, unspecified |
| Rectal pain | |
| K62.89 | Other specified diseases of anus and rectum |
| 0-9 | A-Z |
|---|---|
| K62.7 | Radiation proctitis |
| K62.89 | Other specified diseases of anus and rectum |
| K62.89 | Other specified diseases of anus and rectum |
| K64.0 | First degree hemorrhoids |
| K64.8 | Other hemorrhoids |
| K64.9 | Unspecified hemorrhoids |
| L29.0 | Pruritus ani |
| L29.3 | Anogenital pruritus, unspecified |
| O22.4 | Hemorrhoids in pregnancy |
| O22.40 | Hemorrhoids in pregnancy, unspecified trimester |
| O22.41 | Hemorrhoids in pregnancy, first trimester |
| O22.42 | Hemorrhoids in pregnancy, second trimester |
| O22.43 | Hemorrhoids in pregnancy, third trimester |
| O87.2 | Hemorrhoids in the puerperium |
Formulary Reference Tool