COLD RELIEF PLUS (CHLORPHENIRAMINE MALEATE/PHENYLEPHRINE BITARTRATE/ASPIRIN)

Moderate

• A-hydrocort

• A-methapred

• Accupril

• Accuretic

• Aceon

• acetazolamide

• acetazolamide sodium

• Altace

• Amaryl

• amlodipine-benazepril

• Anucort-hc

• Anusol-hc

• Aristospan Intra-articular

• Aristospan Intralesional

• Arixtra

• benazepril

• benazepril-hydrochlorothiazide

• betamethasone acet & sod phos

• Brintellix

• Brisdelle

• budesonide

• captopril

• captopril-hydrochlorothiazide

• Celestone Soluspan

• Celexa

• citalopram

• colchicine-probenecid

• Colocort

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Cymbalta

• dalteparin (porcine)

• Depacon

• Depakene

• Depakote

• Depakote Er

• Depakote Sprinkles

• Depo-medrol

• desvenlafaxine

• desvenlafaxine fumarate

• desvenlafaxine succinate

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• Diabeta

• Diamox Sequels

• divalproex

• Duetact

• duloxetine

• Effexor Xr

• Elmiron

• enalapril maleate

• enalapril-hydrochlorothiazide

• enalaprilat

• enoxaparin

• Entocort Ec

• Epaned

• escitalopram oxalate

• Ez Use Joint-tunnel-trigger

• Fetzima

• First-duke's

• First-mary's Mouthwash

• Flo-pred

• fludrocortisone

• fluoxetine

• fluvoxamine

• fondaparinux

• fosinopril

• fosinopril-hydrochlorothiazide

• Fragmin

• glimepiride

• glipizide

• glipizide-metformin

• Glucotrol

• Glucotrol Xl

• Glucovance

• glyburide

• glyburide micronized

• glyburide-metformin

• Glynase

• Grx Hicort 25

• Hemril-30

• heparin (porcine)

• heparin (porcine) in D5W

• heparin(porcine) in 0.45% NaCl

• heparin, porcine (PF)

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• Kenalog

• Khedezla

• lepirudin

• levomilnacipran

• Lexapro

• lisinopril

• lisinopril-hydrochlorothiazide

• Lotensin

• Lotrel

• Lovenox

• Luvox Cr

• Mavik

• Medrol

• Medrol (pak)

• methazolamide

• methyldopa

• methyldopa-hydrochlorothiazide

• methyldopate

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• Millipred

• Millipred Dp

• milnacipran

• moexipril

• moexipril-hydrochlorothiazide

• nateglinide

• Neptazane

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• olanzapine-fluoxetine

• Orapred

• Orapred Odt

• paroxetine HCl

• paroxetine mesylate

• Paxil

• Paxil Cr

• Pediapred

• pentosan polysulfate sodium

• perindopril erbumine

• Pexeva

• Physicians Ez Use M-pred

• pioglitazone-glimepiride

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• Prinivil

• Pristiq

• probenecid

• Proctocort

• Prozac

• Prozac Weekly

• quinapril

• quinapril-hydrochlorothiazide

• ramipril

• Rayos

• Rectacort-hc

• Refludan

• reserpine

• Sarafem

• Savella

• sertraline

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Starlix

• Stavzor

• Symbyax

• Tarka

• ticlopidine

• tolazamide

• tolbutamide

• trandolapril

• trandolapril-verapamil

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• Uceris

• Uniretic

• Univasc

• valproate sodium

• valproic acid

• valproic acid (as sodium salt)

• Vaseretic

• Vasotec

• venlafaxine

• Veripred 20

• Viibryd

• vilazodone

• vortioxetine

• Zestoretic

• Zestril

• Zoloft

Moderate

• Acidosis

• Anemia

• Chronic heart failure

• Chronic obstructive pulmonary disease

• Disease of liver

• Hypertension

• Hyperthyroidism

• Hypoxia

• Kidney disease with reduction in GFR

• Nasal polyp

• Vitamin K deficiency

Aspirin (>150Mg)

• Severity Level:

  1

• Additional Notes: No fda category; not recommended especially in 3rd trimester or near term

Chlorpheniramine

• Severity Level:

  2

• Additional Notes: Insufficient data available; neonate risk of seizures;avoid during 3rd trimester

Phenylephrine

• Severity Level:

  2

• Additional Notes: Insufficient human data available.

Contraindicated

Aspirin (>150Mg)

One report of metabolic acidosis; risk of reye's synd in viral illness.

General	Excretion Potential	Effect on Infant	Notes
Drug should not be given to breast feeding mothers	Excreted	Drug shown to have adverse effect	One report of metabolic acidosis; risk of reye's synd in viral illness.

Precaution Exists

Chlorpheniramine

Insufficient data available; may cause sedation and inhibit lactation

Oral bioavailability low; infant exposure may be minimal

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Insufficient data available; may cause sedation and inhibit lactation

Phenylephrine

Insufficient data available; may cause sedation and inhibit lactation

Oral bioavailability low; infant exposure may be minimal

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Oral bioavailability low; infant exposure may be minimal

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Chlorpheniramine

Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.

Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	N	N	Y	N	N

BEERS: Y     HEDIS: Y     STOPP: Y

Phenylephrine

Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.

Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	N	Y	Y	N	N

BEERS: N     HEDIS: N     STOPP: N

No Known Risk

None

0-9	A-Z
H10.1	Acute atopic conjunctivitis
H10.10	Acute atopic conjunctivitis, unspecified eye
H10.11	Acute atopic conjunctivitis, right eye
H10.12	Acute atopic conjunctivitis, left eye
H10.13	Acute atopic conjunctivitis, bilateral
H10.44	Vernal conjunctivitis
H10.45	Other chronic allergic conjunctivitis
H16.26	Vernal keratoconjunctivitis, with limbar and corneal involvement
H16.261	Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye
H16.262	Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye
H16.263	Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral
H16.269	Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye
J02.9	Acute pharyngitis, unspecified
J30.1	Allergic rhinitis due to pollen
J30.2	Other seasonal allergic rhinitis
J30.5	Allergic rhinitis due to food
J30.8	Other allergic rhinitis
J30.81	Allergic rhinitis due to animal (cat) (dog) hair and dander
J30.89	Other allergic rhinitis
J30.9	Allergic rhinitis, unspecified
R05	Cough
R09.81	Nasal congestion
R09.81	Nasal congestion
R09.82	Postnasal drip
R50.9	Fever, unspecified
R51	Headache
R53.1	Weakness
R53.81	Other malaise
R53.83	Other fatigue
R68.83	Chills (without fever)