COLD MULTI-SYMPTOM DAY/NIGHT (dextromethorphan/phenylephrine/acetaminophen/chlorpheniramin)


Drug overview for COLD MULTI-SYMPTOM DAY/NIGHT (dextromethorphan/phenylephrine/acetaminophen/chlorpheniramin):

Generic name: dextromethorphan/phenylephrine/acetaminophen/chlorpheniramin
Drug class: Amphetamines/Anorexiants/Stimulants
Therapeutic class: Respiratory Therapy Agents

Acetaminophen is a synthetic nonopiate derivative of p-aminophenol that Chlorpheniramine is an alkylamine (propylamine)-derivative, first Dextromethorphan, a derivative of levorphanol, is an antitussive agent. Phenylephrine hydrochloride is a sympathomimetic amine that predominantly acts by a direct effect on alpha1-adrenergic receptors. generation antihistamine. produces analgesia and antipyresis.

Acetaminophen is used extensively in the treatment of mild to moderate pain Dextromethorphan is used for the temporary relief of coughs caused by minor and fever. throat and bronchial irritation such as may occur with common colds or with inhaled irritants. Dextromethorphan is most effective in the treatment of chronic, nonproductive cough.

The drug is a common ingredient in commercial cough mixtures available without prescription. Although cough and cold preparations that contain cough suppressants (including dextromethorphan), nasal decongestants, antihistamines, and/or expectorants commonly are used in pediatric patients younger than 2 years of age, systematic reviews of controlled trials have concluded that nonprescription (over-the-counter, OTC) cough and cold preparations are not more effective than placebo in reducing acute cough and other symptoms of upper respiratory tract infection in these patients. Furthermore, adverse events, including deaths, have been (and continue to be) reported in pediatric patients younger than 2 years of age receiving these preparations.

(See Cautions: Pediatric Precautions and see Acute Toxicity: Manifestations.) For information on abuse of dextromethorphan, see Cautions. For use of dextromethorphan hydrobromide in fixed combination with quinidine sulfate in the treatment of pseudobulbar affect (PBA), see Dextromethorphan Hydrobromide and Quinidine Sulfate 28:92.
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The following indications for COLD MULTI-SYMPTOM DAY/NIGHT (dextromethorphan/phenylephrine/acetaminophen/chlorpheniramin) have been approved by the FDA:

Indications:
Cold symptoms
Cough
Fever
Flu-like symptoms
Headache disorder
Nasal congestion
Rhinorrhea


Professional Synonyms:
Cephalgia
Cephalodynia
Febrile reaction
Febrile
Nasal stuffiness
Pyrexia