CHILD COLD-COUGH DAY-NIGHT (DIPHENHYDRAMINE HCL/PHENYLEPHRINE HCL/DEXTROMETHORPHAN HBR)
- Cold symptoms
- Allergic rhinitis
- Cough
- Nasal congestion
- Rhinorrhea
- Vasomotor rhinitis
6.25 mg-2.5 mg-5 mg/5 mL oral solution
- Dosage information is not available
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- bromocriptine
- cabergoline
- Cafergot
- Compound 347
- Cycloset
- D.h.e.45
- dihydroergotamine
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- isoflurane
- methylergonovine
- Migergot
- Migranal
- Parlodel
- sevoflurane
- Sojourn
- Soltamox
- tamoxifen
- Terrell
- Ultane
Severe
Moderate
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Acute myocardial infarction
- Arterial thrombosis
- Severe uncontrolled hypertension
- Ventricular tachycardia
Contraindicated
- Acute hepatitis
- Acute pancreatitis
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Bradycardia
- Chronic idiopathic constipation
- Coronary artery disease
- Hypertension
- Hyperthyroidism
- Incomplete AV heart block
- Severe arteriosclerotic vascular disease
- Stenosing peptic ulcer
- Systemic mastocytosis
- Urinary retention
Severe
Moderate
- Acidosis
- Chronic heart failure
- Hypertension
- Hyperthyroidism
- Hypoxia
- Ocular hypertension
CHILD COLD-COUGH DAY-NIGHT (DIPHENHYDRAMINE HCL/PHENYLEPHRINE HCL/DEXTROMETHORPHAN HBR)
- Cold symptoms
- Allergic rhinitis
- Cough
- Nasal congestion
- Rhinorrhea
- Vasomotor rhinitis
- None
- Dizziness
- Drowsy
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Blood dyscrasias
- Cardiac arrhythmia
- Dizziness
- Extrasystoles
- Hallucinations
- Headache disorder
- Hemolytic anemia
- Hyperhidrosis
- Hypotension
- Insomnia
- Nervousness
- Pallor
- Seizure disorder
- Tachycardia
- Tremor
- Vomiting
Less Severe
- Abdominal distension
- Abdominal pain with cramps
- Acute abdominal pain
- Acute confusion
- Anorexia
- Ataxia
- Blurred vision
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dizziness
- Drowsy
- Dry nose
- Dry throat
- Dyspnea
- Dysuria
- Euphoria
- Excitement
- Fatigue
- Headache disorder
- Hyperhidrosis
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Migraine
- Nausea
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Wheezing
- Xerostomia
Contraindicated
Dextromethorphan (OTC)
Do not use in pediatrics <6 years of age unless clinician consultation.
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 30 Days – 6 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 29 Days
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
Diphenhydramine (Cough-Cold)
Do not use in pediatrics <6 years of age unless clinician consultation.
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
- 30 Days – 6 Years
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
- 1 Day – 29 Days
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Diphenhydramine (Systemic)
Do not use in pediatrics <6 years of age unless clinician consultation.
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Possible risk of CNS excitation, convulsions in newborns.
- 30 Days – 6 Years
- 1 Possible risk of CNS excitation, convulsions in newborns.
- 1 Day – 29 Days
- 1 Possible risk of CNS excitation, convulsions in newborns.
Phenylephrine (Oral,Rectal)
Do not use in pediatrics <6 years of age unless clinician consultation.
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 30 Days – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 29 Days
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
Severe Precaution
None
Management or Monitoring Precaution
None
Dextromethorphan
- Severity Level:
C
- Additional Notes:
Diphenhydramine
- Severity Level:
B
- Additional Notes:
Phenylephrine
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Dextromethorphan
Insufficient data available; molecular wt low enough for possible excretion
Limited data suggest increased drowsiness, and irritability
Oral bioavailability low; infant exposure may be minimal
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; molecular wt low enough for possible excretion |
Diphenhydramine
Insufficient data available; molecular wt low enough for possible excretion
Limited data suggest increased drowsiness, and irritability
Oral bioavailability low; infant exposure may be minimal
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest increased drowsiness, and irritability |
Phenylephrine
Insufficient data available; molecular wt low enough for possible excretion
Limited data suggest increased drowsiness, and irritability
Oral bioavailability low; infant exposure may be minimal
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Oral bioavailability low; infant exposure may be minimal |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Diphenhydramine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Phenylephrine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
Cold symptoms | |
J00 | Acute nasopharyngitis [common cold] |
Cough | |
R05 | Cough |
Nasal congestion | |
R09.81 | Nasal congestion |
Rhinorrhea | |
R09.82 | Postnasal drip |
Vasomotor rhinitis | |
J30.0 | Vasomotor rhinitis |
0-9 | A-Z |
---|---|
J00 | Acute nasopharyngitis [common cold] |
J30.0 | Vasomotor rhinitis |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
R05 | Cough |
R09.81 | Nasal congestion |
R09.82 | Postnasal drip |