ALLERGY EYE (naphazoline hcl/pheniramine maleate)

There are 1 contraindications. Absolute contraindication.

Contraindication List
Angle-closure glaucoma

There are 0 severe contraindications.

There are 5 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Diabetes mellitus
Hypertension
Hyperthyroidism
Ocular infection
Ocular injury

There are 5 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Dizziness Hyperhidrosis Hypertension Ocular hypertension Punctate keratitis

There are 10 less severe adverse reactions.

More Frequent	Less Frequent
None.

Rare/Very Rare
Drowsy General weakness Headache disorder Hyperglycemia Nausea Nervousness Photophobia

Animal studies have not been conducted with naphazoline hydrochloride, and it is not known whether the drug can cause fetal harm when administered to a pregnant woman. Therefore, naphazoline hydrochloride should be used during pregnancy only when clearly needed.

Drug/Drug Class	Severity	Precaution Description	Pregnancy Category Description
Pheniramine Maleate	2	Antihist use last 2 wks of preg assoc w/retrolental fibroplasia in premature inf	No fda rating but may have precautions or warnings; may have animal and/or human studies or pre or post marketing information.
Naphazoline	C	Insufficient data available	Animal studies have shown adverse effect on fetus but no well-controlled studies in humans: potential benefits may warrant use in pregnant women despite potential risks; or no animal reproduction studies and no adequate and well-controlled studies in humans.

It is not known whether naphazoline hydrochloride is distributed into milk. Because many drugs are distributed into milk, caution should be exercised when this drug is administered to a breast-feeding woman.

Precaution Exists
Precaution exists. (No data or inconclusive human data.) Use of this drug by breast feeding mothers should be evaluated carefully.

Drug Name	Excretion Potential	Effect on Infant	Notes
Naphazoline	Unknown. It is unknown whether the drug is excreted in human breast milk.	It is not known whether this drug has an adverse effect on the nursing infant. (No data or inconclusive human data)	Insufficient human data available; infant exposure unlikely
Pheniramine	Unknown. It is unknown whether the drug is excreted in human breast milk.	It is not known whether this drug has an adverse effect on the nursing infant. (No data or inconclusive human data)	Insufficient human data available

No enhanced Geriatric Use information available for this drug.