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Drug overview for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
Generic name: PYRIDOXINE HCL (PIR-i-DOX-een)
Drug class: Vitamin B-6
Therapeutic class: Electrolyte Balance-Nutritional Products
Vitamin B6 (as pyridoxine, pyridoxal, and pyridoxamine) is a water-soluble, B complex vitamin.
No enhanced Uses information available for this drug.
Generic name: PYRIDOXINE HCL (PIR-i-DOX-een)
Drug class: Vitamin B-6
Therapeutic class: Electrolyte Balance-Nutritional Products
Vitamin B6 (as pyridoxine, pyridoxal, and pyridoxamine) is a water-soluble, B complex vitamin.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl) have been approved by the FDA:
Indications:
Drug-induced pyridoxine deficiency
Pyridoxine deficiency
Pyridoxine-dependent seizure
Professional Synonyms:
Pyridoxine-dependent epilepsy
Pyridoxol-dependent seizures
Vitamin B6 dependent convulsions
Indications:
Drug-induced pyridoxine deficiency
Pyridoxine deficiency
Pyridoxine-dependent seizure
Professional Synonyms:
Pyridoxine-dependent epilepsy
Pyridoxol-dependent seizures
Vitamin B6 dependent convulsions
The following dosing information is available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
Although pyridoxine was previously considered nontoxic even at high dosages, current evidence indicates that chronic administration of large dosages (e.g., 2 g daily) for the management of various conditions can cause severe adverse neurologic effects, and the risk to benefit of such dosages must be carefully weighed. (See Chronic Toxicity.)
Pyridoxine hydrochloride is usually administered orally; however, the drug may be given by IM, IV, or subcutaneous injection when oral administration is not feasible. In infants with seizures, pyridoxine hydrochloride should be administered by IM or IV injection.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
There are 0 contraindications.
There are 0 severe interactions.
There are 1 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Levodopa/Pyridoxine SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Pyridoxine increases levodopa metabolism, decreasing the amount of levodopa available to the central nervous system. CLINICAL EFFECTS: The pharmacologic effects of levodopa may be decreased. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Avoid pyridoxine in patients receiving levodopa alone; however, the interaction can be minimized by giving levodopa with a peripheral decarboxylase inhibitor (e.g. carbidopa, benserazide). DISCUSSION: In patients with Parkinson's disease, as little as 10 mg of pyridoxine may reverse the clinical benefits as well as the adverse effects of levodopa. Coadministration of levodopa with either carbidopa or benserazide has minimized the effects of this interaction. |
INBRIJA, LEVODOPA |
The following contraindication information is available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 0 contraindications.
There are 0 severe contraindications.
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| No disease contraindications |
The following adverse reaction information is available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 1 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Peripheral sensory neuropathy |
There are 4 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Drowsy Headache disorder Nausea Paresthesia |
The following precautions are available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for PYRIDOXINE (VITAMIN B6) (pyridoxine hcl)'s list of indications:
| Drug-induced pyridoxine deficiency | |
| E53.1 | Pyridoxine deficiency |
| Pyridoxine deficiency | |
| E53.1 | Pyridoxine deficiency |
| Pyridoxine-dependent seizure | |
| G40.801 | Other epilepsy, not intractable, with status epilepticus |
| G40.802 | Other epilepsy, not intractable, without status epilepticus |
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