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PROPAFENONE HCL ER (propafenone HCl)
- Prevention of recurrent atrial fibrillation
225 mg capsule,extended release
- 1 capsule (225 mg) by oral route every 12 hours
325 mg capsule,extended release
- 1 capsule (325 mg) by oral route every 12 hours
425 mg capsule,extended release
- 1 capsule (425 mg) by oral route every 12 hours
ER 225 mg capsule,extended release 12 hr
- 1 capsule (225 mg) by oral route every 12 hours
ER 325 mg capsule,extended release 12 hr
- 1 capsule (325 mg) by oral route every 12 hours
ER 425 mg capsule,extended release 12 hr
- 1 capsule (425 mg) by oral route every 12 hours
propafenone ER 225 mg capsule,extended release 12 hr
- 1 capsule (225 mg) by oral route every 12 hours
propafenone ER 325 mg capsule,extended release 12 hr
- 1 capsule (325 mg) by oral route every 12 hours
propafenone ER 425 mg capsule,extended release 12 hr
- 1 capsule (425 mg) by oral route every 12 hours
Prevention of recurrent atrial fibrillation
- 1 capsule (225 mg) by oral route every 12 hours
- 1 capsule (225 mg) by oral route 2 times per day
- 1 capsule (325 mg) by oral route 2 times per day
- 1 capsule (325 mg) by oral route every 12 hours
- 1 capsule (425 mg) by oral route every 12 hours
- 1 capsule (425 mg) by oral route 2 times per day
- amiodarone
- amiodarone in dextrose,iso-osm
- Aptivus
- artemether-lumefantrine
- Betapace
- Betapace Af
- Coartem
- Cordarone
- Corvert
- dextromethorphan-quinidine
- disopyramide
- dofetilide
- dronedarone
- droperidol
- fosamprenavir
- ibutilide fumarate
- Invirase
- Kaletra
- Lexiva
- lopinavir-ritonavir
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Nuedexta
- Orap
- Pacerone
- pimozide
- procainamide
- quinidine gluconate
- quinidine sulfate
- ritonavir
- saquinavir mesylate
- Sorine
- sotalol
- Sotalol Af
- Tikosyn
- tipranavir
Contraindicated
- arsenic trioxide
- Caprelsa
- chloroquine phosphate
- chlorpromazine
- dasatinib
- Digox
- digoxin
- Diskets
- Dolophine
- Fareston
- fingolimod
- Geodon
- Gilenya
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- isradipine
- Lanoxin
- Lanoxin Pediatric
- methadone
- Methadone Intensol
- Methadose
- mirabegron
- Myrbetriq
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- paliperidone
- paliperidone palmitate
- Pentam
- pentamidine
- Qualaquin
- quinine sulfate
- Sprycel
- Tasigna
- tetrabenazine
- tizanidine
- toremifene
- Trisenox
- vandetanib
- Xenazine
- Zanaflex
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Advair Diskus
- Advair Hfa
- alfuzosin
- amantadine HCl
- Anzemet
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Azilect
- bedaquiline
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- clozapine
- Clozaril
- Complera
- Coumadin
- crizotinib
- Diflucan
- dolasetron
- Dutoprol
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- escitalopram oxalate
- ezogabine
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluoxetine
- fluticasone-salmeterol
- foscarnet
- Foscavir
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Hecoria
- indapamide
- Inderal La
- Inderal Xl
- Innopran Xl
- isoniazid-rifamp-pyrazinamide
- Istodax
- Jantoven
- Ketek
- Lamisil
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lithium carbonate
- lithium citrate
- Lithobid
- Lopressor
- Lopressor Hct
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- moexipril
- moexipril-hydrochlorothiazide
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- olanzapine-fluoxetine
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- pasireotide
- pazopanib
- posaconazole
- Potiga
- Priftin
- Prograf
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- quetiapine
- rasagiline
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Sarafem
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Soltamox
- sorafenib
- sunitinib
- Sutent
- Symbyax
- tacrolimus
- tamoxifen
- telavancin
- telithromycin
- terbinafine
- Toprol Xl
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- warfarin
- Xalkori
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Acute hypotension
- Agranulocytosis
- Atrioventricular block
- Bradycardia
- Bronchospastic pulmonary disease
- Brugada syndrome
- Bundle branch block
- Cardiogenic shock
- Chronic heart failure
- Hyperkalemia
- Hypokalemia
- Severe chronic obstructive pulmonary disease
- Torsades de pointes
Contraindicated
- 30 day risk period post-myocardial infarction
- Acute myocardial infarction
- Congenital long QT syndrome
- Myasthenia gravis
- Prolonged QT interval
- Severe coronary artery disease
- Sick sinus syndrome
- Structural disorder of heart
Severe
Moderate
- CYp2d6 poor metabolizer
- Disease of liver
- Kidney disease with reduction in GFR
PROPAFENONE HCL ER (propafenone HCl)
- Prevention of recurrent atrial fibrillation
- Ventricular tachycardia
- Constipation
- Dizziness
- Dysgeusia
- Dyspnea
- Edema
- Influenza
- Palpitations
- Symptoms of anxiety
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Angina
- Atrioventricular block
- Chronic heart failure
- Blurred vision
- Chest pain
- Depression
- Diarrhea
- Ecchymosis
- Fatigue
- General weakness
- Headache disorder
- Nausea
- Rales
- Tremor
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute respiratory insufficiency
- Agranulocytosis
- Atelectasis
- Atrial flutter
- Bradycardia
- Bundle branch block
- Cardiac arrhythmia
- Cerebrovascular accident
- Diabetes mellitus
- Gastrointestinal obstruction
- Gout
- Hemoptysis
- Hemorrhage
- Hepatomegaly
- Hypertension
- Hypokalemia
- Hypotension
- Neuromuscular blockade
- Neutropenic disorder
- Ocular hemorrhage
- Pancreatitis
- Paralysis
- Paroxysmal supraventricular tachycardia
- Peptic ulcer
- Pleural effusions
- Prolonged QT interval
- Pulmonary congestion
- Rectal bleeding
- Renal failure
- Retinal disorder
- Tendonitis
- Throat constriction
- Thrombocytopenic disorder
- Thromboembolic disorder
- Urinary retention
- Ventricular fibrillation
Less Severe
- Abdominal distension
- Acute abdominal pain
- Alopecia
- Anorexia
- Arthritis
- Ataxia
- Black tarry stools
- Blepharoptosis
- Bursitis
- Cough
- Cramps
- Dehydration
- Dementia
- Dry skin
- Duodenitis
- Dysarthria
- Dyspepsia
- Dysphagia
- Dysuria
- Epistaxis
- Erectile dysfunction
- Eructation
- Erythema
- Fever
- Gait abnormality
- Gastritis
- Gastroesophageal reflux disease
- Gingival bleeding
- Gingival pain
- Glossitis
- Halitosis
- Hypercholesterolemia
- Hyperglycemia
- Hyperhidrosis
- Hypertonia
- Hypesthesia
- Increased urinary frequency
- Insomnia
- Libido changes
- Lymphadenopathy
- Malaise
- Mastalgia
- Memory impairment
- Miosis
- Mood changes
- Muscle spasm
- Myalgias
- Nail disorders
- Neck pain
- Nightmares
- Nocturia
- Ocular inflammation
- Oliguria
- Pain
- Pallor
- Paresthesia
- Petechiae
- Prostatitis
- Pruritus of skin
- Pyuria
- Reduced visual acuity
- Rhinitis
- Sciatica
- Sensation of warmth
- Skin inflammation
- Sleep disorder
- Sore throat
- Sore tongue
- Stomatitis
- Syncope
- Tinnitus
- Urinary incontinence
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Propafenone
No safety and efficacy established in pediatrics.
- 1 Day – 18 Years
- No safety and efficacy established in pediatrics.
Propafenone
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Propafenone
Excretion occurs in humans, manufacturer suggests caution
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Excretion occurs in humans, manufacturer suggests caution |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Propafenone
Renal-Active metabolites excreted. No renal dosing information available. Slow dose escalation in initial treatment. Monitor overdose symptoms: hypotension, somnolence, bradycardia, intra-atrial and ventricular conduction disturbances. Hepatic-Highly metabolized. Decrease by 20-30% for hepatic impairment. Cardiovascular-Progressive AV block and QRS widening observed with increasing doses. Avoid use in patients with sick sinus syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Though this medication often gives great benefits to people with irregular heartbeat, it may rarely cause a serious new irregular heartbeat. Talk with your doctor about the benefits and risks of taking this medication.
| Prevention of recurrent atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
| 0-9 | A-Z |
|---|---|
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
Formulary Reference Tool