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EPIVIR (LAMIVUDINE)
- HIV infection
100 mg tablet
- 1 tablet (100 mg) by oral route once daily
150 mg tablet
- 1 tablet (150 mg) by oral route every 12 hours
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
10 mg/mL oral solution
- 15 milliliters (150 mg) by oral route every 12 hours
25 mg/5 mL (5 mg/mL) oral solution
- 20 milliliters (100 mg) by oral route once daily
150 mg tablet
- 1 tablet (150 mg) by oral route every 12 hours
300 mg tablet
- 1 tablet (300 mg) by oral route once daily
10 mg/mL oral solution
- 15 milliliters (150 mg) by oral route every 12 hours
HIV infection
- 10 milliliters (100 mg) by oral route 2 times per day
- 10 milliliters (100 mg) by oral route every 12 hours
- 15 milliliters (150 mg) by oral route 2 times per day
- 1 tablet (150 mg) by oral route every 12 hours
- 1 tablet (150 mg) by oral route 2 times per day
- 15 milliliters (150 mg) by oral route every 12 hours
- 2 tablets (300 mg) by oral route once daily
- 1 tablet (300 mg) by oral route once daily
- 30 milliliters (300 mg) by oral route once daily
- None
Contraindicated
- None
Severe
Moderate
- None
- Acute pancreatitis
- Chronic pancreatitis
- Lactating mother
- Lactic acidosis
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
Severe
Moderate
- Kidney disease with likely reduction in GFR
EPIVIR (LAMIVUDINE)
- HIV infection
- Elevated serum lipase
- Paresthesia
- Cough
- Diarrhea
- Fatigue
- Fever
- Headache disorder
- Infection of ear
- Malaise
- Nausea
- Peripheral neuropathy
- Sore throat
More Frequent
Severe
Less Severe
- Neutropenic disorder
- Thrombocytopenic disorder
- Abdominal pain with cramps
- Anorexia
- Arthralgias
- Chills
- Dizziness
- Dyspepsia
- Insomnia
- Myalgias
- Rhinitis
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Anemia
- Lactic acidosis
- Lymphadenopathy
- Pancreatitis
- Pure red cell aplasia
- Rhabdomyolysis
- Splenomegaly
- Steatosis of liver
Less Severe
- Alopecia
- Cramps
- General weakness
- Hyperglycemia
- Muscle weakness
- Pruritus of skin
- Skin rash
- Stomatitis
- Urticaria
- Wheezing
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Lamivudine
Safety and efficacy not established in pediatrics age less than 3 months.
Increased risk of pancreatitis with prior antiretroviral nucleoside (NRTI) exposure or other risk factors. Tablet dose form preferred for weight >14 kg.
- 1 Day – 89 Days
- Safety and efficacy not established in pediatrics age less than 3 months.
- Increased risk of pancreatitis with prior antiretroviral nucleoside (NRTI) exposure or other risk factors. Tablet dose form preferred for weight >14 kg.
- 90 Days – 18 Years
- Safety and efficacy not established in pediatrics age less than 3 months.
- Increased risk of pancreatitis with prior antiretroviral nucleoside (NRTI) exposure or other risk factors. Tablet dose form preferred for weight >14 kg.
Lamivudine
- Severity Level:
2
- Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects
Contraindicated
Lamivudine
Avoid breastfeeding in hiv positive women per cdc
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Avoid breastfeeding in hiv positive women per cdc |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- If you have hepatitis B infection along with HIV, your hepatitis symptoms may get worse or become very serious if you stop taking lamivudine. Talk with your doctor before stopping this medication. Your doctor will perform liver function tests for several months after you stop lamivudine.<br /><br />Tell your doctor right away if you develop symptoms of worsening liver problems. Different brands of this drug have different amounts of drug. Do not switch brands of this medication without first checking with your doctor.<br /><br />If you have HIV infection (with or without hepatitis B infection), you should be taking the higher-strength dosage. Consult your doctor or pharmacist.
| HIV infection | |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
| 0-9 | A-Z |
|---|---|
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
Formulary Reference Tool