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MIRCERA (METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA)
- Anemia in chronic kidney disease
100 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (100 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
150 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (150 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
200 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (200 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
30 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (30 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
50 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (50 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
75 mcg/0.3 mL injection syringe
- Inject 0.3 milliliter (75 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
Anemia in chronic kidney disease
- Inject 0.6 mcg/kg by intravenous route every 2 weeks
- Inject 0.6 mcg/kg by intravenous route once a month
- Inject 0.3 milliliter (30 mcg) by intravenous route every 2 weeks
- Inject 0.3 milliliter (30 mcg) by intravenous route once a month
- Inject 0.3 milliliter (30 mcg) by subcutaneous route every 2 weeks inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (30 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (50 mcg) by intravenous route every 2 weeks
- Inject 0.3 milliliter (50 mcg) by intravenous route once a month
- Inject 0.3 milliliter (50 mcg) by subcutaneous route every 2 weeks inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (50 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (75 mcg) by intravenous route every 2 weeks
- Inject 0.3 milliliter (75 mcg) by intravenous route once a month
- Inject 0.3 milliliter (75 mcg) by subcutaneous route every 2 weeks inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (75 mcg) by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (100 mcg) by intravenous route every 2 weeks
- Inject 0.3 milliliter (100 mcg) by intravenous route once a month
- Inject 0.3 milliliter (100 mcg) by subcutaneous route every 2 weeks in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (100 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (150 mcg) by intravenous route every 2 weeks
- Inject 0.3 milliliter (150 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (150 mcg) by subcutaneous route every 2 weeks in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (150 mcg) by intravenous route once a month
- Inject 0.3 milliliter (200 mcg) by subcutaneous route once a month inthe abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 0.3 milliliter (200 mcg) by intravenous route once a month
- Inject 0.6 mcg/kg by subcutaneous route every 2 weeks in the abdomen,thigh, or outer area of upper arm (rotate sites)
- Inject 0.6 mcg/kg by subcutaneous route once a month in the abdomen, thigh, or outer area of upper arm (rotate sites)
- None
Contraindicated
- None
Severe
Moderate
- None
- Pure red cell aplasia
- Severe uncontrolled hypertension
Contraindicated
- Acute decompensated heart failure
- Acute myocardial infarction
- Cerebrovascular accident
- Coronary artery disease
- Deep venous thrombosis
- Pulmonary thromboembolism
- Thromboembolic disorder
- Vascular access thrombosis
Severe
Moderate
- Folate deficiency
- Hypertension
- Increased cardiovascular event risk
- Iron deficiency anemia
- Porphyria
- Seizure disorder
- Vitamin b12 deficiency
MIRCERA (METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA)
- Anemia in chronic kidney disease
- Edema
- Fever
- Hypertension
- Tachycardia
- Vascular access thrombosis
- Arthralgias
- Diarrhea
- Fatigue
- General weakness
- Injection site sequelae
- Muscle spasm
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Acute myocardial infarction
- Cerebrovascular accident
- Headache disorder
- Hypokalemia
- Pulmonary thromboembolism
- Seizure disorder
- Thrombotic disorder
- Transient cerebral ischemia
- Bone pain
- Depression
- Dizziness
- Dysphagia
- Hyperglycemia
- Myalgias
- Stomatitis
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angioedema
- Chest pain
- Chronic heart failure
- Deep venous thrombosis
- Erythema multiforme
- Porphyria
- Pure red cell aplasia
- Shortened time to tumor progression
- Skin rash
- Stevens-johnson syndrome
- Thromboembolic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Chills
- Flu-like symptoms
- Hyperhidrosis
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Epoetin beta
No safety and efficacy established age < 5 years.
- 1 Day – 5 Years
- No safety and efficacy established age < 5 years.
Epoetin Beta
- Severity Level:
2
- Additional Notes: Insufficient human data available
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Epoetin Beta
Insufficient human data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Discuss the risks and benefits of methoxy polyethylene glycol-epoetin beta with your doctor, as this medication may rarely cause very serious (possibly fatal) side effects, including blood clots, heart attack, stroke, or heart failure. It is very important to keep all lab appointments since your doctor will need to carefully check your red blood cell count and hemoglobin level. The lowest effective dose of this medication should be used.<br /><br /> When used to treat anemia related to cancer, this medication may also increase the risk of death and/or cause the tumor to grow faster. This medication is not approved for the treatment of anemia related to cancer. Ask your doctor about the risks and benefits of this medication, as well as other effective and possibly safer treatments for anemia related to cancer.
Anemia in chronic kidney disease | |
D63.1 | Anemia in chronic kidney disease |
N18.4 | Chronic kidney disease, stage 4 (severe) |
N18.5 | Chronic kidney disease, stage 5 |
N18.6 | End stage renal disease |
Z99.2 | Dependence on renal dialysis |
0-9 | A-Z |
---|---|
D63.1 | Anemia in chronic kidney disease |
N18.4 | Chronic kidney disease, stage 4 (severe) |
N18.5 | Chronic kidney disease, stage 5 |
N18.6 | End stage renal disease |
Z99.2 | Dependence on renal dialysis |
Formulary Reference Tool