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ZYPRAM (HYDROCORTISONE ACETATE/PRAMOXINE HCL)
- Skin inflammation
- Pruritus ani
2.35 %-1 % kit,cream and towelette
- Dosage information is not available
- None
Contraindicated
- None
Severe
Moderate
- None
- Intestinal abscess
- Untreated systemic fungal infection
Contraindicated
- Active tuberculosis
- Diabetes mellitus
- Infection
- Intestinal anastomosis
- Large open wound
- Ocular herpes simplex
- Ocular hypertension
Severe
Moderate
- Chronic heart failure
- Diverticulitis of gastrointestinal tract
- Gastrointestinal fistula
- Herpes simplex infection
- Hypertension
- Hyperthyroidism
- Hypothyroidism
- Kidney disease with reduction in GFR
- Measles
- Open angle glaucoma
- Osteoporosis
- Psychotic disorder
- Varicella zoster virus infection
ZYPRAM (HYDROCORTISONE ACETATE/PRAMOXINE HCL)
- Skin inflammation
- Pruritus ani
- Infection
- Increased appetite
More Frequent
Severe
Less Severe
- Adrenal cortical insufficiency
- Angioedema
- Dermatitis due to topical drug
- Erythema
- Hypercortisolism
- Pruritus of skin
- Skin rash
- Stinging of skin
- Urticaria
- Irregular menstrual periods
- Nausea
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abdominal distension
- Abnormal hepatic function tests
- Acute confusion
- Acute respiratory insufficiency
- Anaphylaxis
- Body fluid retention
- Bradycardia
- Cardiac arrhythmia
- Cataracts
- Chronic heart failure
- CNS toxicity
- Cyanosis
- Delirium
- Drowsy
- Drug-induced psychosis
- Dyspnea
- Excitement
- Eyelid edema
- Gastrointestinal hemorrhage
- Glaucoma
- Glycosuria
- Hallucinations
- Headache disorder
- Hepatomegaly
- Hyperglycemia
- Hypertension
- Hypotension
- Idiopathic intracranial hypertension
- Impaired wound healing
- Intestinal perforation
- Methemoglobinemia
- Myopathy
- Ocular hypertension
- Osteoporosis
- Paranoid disorder
- Peptic ulcer
- Personality disorders
- Pulmonary edema
- Respiratory depression
- Seizure disorder
- Thromboembolic disorder
- Tremor
- Unconsciousness
Less Severe
- Acne vulgaris
- Acute confusion
- Allergic dermatitis
- Apprehension
- Blurred vision
- Depression
- Dizziness
- Edema
- Euphoria
- Flushing
- Hirsutism
- Insomnia
- Lipodystrophy
- Mood changes
- Nervousness
- Rectal irritation
- Sensation of cold
- Sensation of warmth
- Sleep disorder
- Tinnitus
- Twitching
- Vomiting
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Hydrocortisone (Top,Ophth,Rect)
Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
Pediatrics are more sensitive to toxic effects.
- 1 Day – 18 Years
- Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
- 1 Day – 12 Years
- Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
Pramoxine
Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
Pediatrics are more sensitive to toxic effects.
- 1 Day – 18 Years
- Pediatrics are more sensitive to toxic effects.
- 1 Day – 12 Years
- Pediatrics are more sensitive to toxic effects.
Hydrocortisone (topical, Non-systemic)
- Severity Level:
2
- Additional Notes: Systemic absorption unknown; insuff human data
Pramoxine
- Severity Level:
C
- Additional Notes: Insufficient human data
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Pramoxine
Per briggs, unlikely that significant amounts would be excreted in milk
May accumulate in liver;Maternal suppl not rec unless diet insuffic in vit e
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Per briggs, unlikely that significant amounts would be excreted in milk |
Vitamin E (systemic)
Per briggs, unlikely that significant amounts would be excreted in milk
May accumulate in liver;Maternal suppl not rec unless diet insuffic in vit e
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | No adverse effect | May accumulate in liver;Maternal suppl not rec unless diet insuffic in vit e |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Pruritus ani | |
| L29.0 | Pruritus ani |
| L29.3 | Anogenital pruritus, unspecified |
| Skin inflammation | |
| L30.8 | Other specified dermatitis |
| L30.9 | Dermatitis, unspecified |
| 0-9 | A-Z |
|---|---|
| L29.0 | Pruritus ani |
| L29.3 | Anogenital pruritus, unspecified |
| L30.8 | Other specified dermatitis |
| L30.9 | Dermatitis, unspecified |
Formulary Reference Tool