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SYMDEKO (tezacaftor/ivacaftor)
- Cystic fibrosis with heterozyg f508del mutation in CFTR
- Cystic fibrosis with homozyg f508del mutation in CFTR
- Cystic fibrosis with class III CFTR mutation
- Cystic fibrosis with r117H mutation in CFTR gene
100 mg-150 mg (day)/150 mg (night) tablets
- Dosage information is not available
50 mg-75 mg (day)/75 mg (night) tablets
- Dosage information is not available
- Korlym
- Mifeprex
- mifepristone
Contraindicated
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- Cold & Flu Fighter
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- fosphenytoin
- Hycamtin
- isoniazid-rifamp-pyrazinamide
- Luminal
- Mycobutin
- Mysoline
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- St. John's wort
- Tegretol
- Tegretol Xr
- topotecan
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
Severe
Moderate
- afatinib
- Afinitor
- Afinitor Disperz
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Diamode
- Etopophos
- etoposide
- etoposide phosphate
- everolimus
- Gilotrif
- Imodium Multi-symptom Relief
- Lo-peramide
- loperamide
- loperamide-simethicone
- Toposar
- Ultra A-d
- Zortress
- None
Contraindicated
- Abnormal hepatic function tests
- Disease of liver
Severe
Moderate
- Cataracts
- Kidney disease with reduction in GFR
SYMDEKO (tezacaftor/ivacaftor)
- Cystic fibrosis with heterozyg f508del mutation in CFTR
- Cystic fibrosis with homozyg f508del mutation in CFTR
- Cystic fibrosis with class III CFTR mutation
- Cystic fibrosis with r117H mutation in CFTR gene
- None
- Dizziness
- Headache disorder
- Nasal congestion
- Nausea
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cataracts
- Gastrointestinal obstruction
- Influenza
Less Severe
- None
Contraindicated
None
Severe Precaution
Tezacaftor, ivacaftor
Risk of cataracts; no safety and efficacy age < 6 years.
Risk of cataracts; check baseline and follow-up ophthalmological exam.
- 1 Day – 6 Years
- Risk of cataracts; no safety and efficacy age < 6 years.
- Risk of cataracts; check baseline and follow-up ophthalmological exam.
- 6 Years – 18 Years
- Risk of cataracts; no safety and efficacy age < 6 years.
- Risk of cataracts; check baseline and follow-up ophthalmological exam.
Management or Monitoring Precaution
None
Tezacaftor-ivacaftor
- Severity Level:
2
- Additional Notes: Insufficient human data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tezacaftor-ivacaftor
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Cystic fibrosis with class III CFTR mutation | |
| E84 | Cystic fibrosis |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.9 | Cystic fibrosis, unspecified |
| Cystic fibrosis with heterozyg f508del mutation in CFTR | |
| E84 | Cystic fibrosis |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.9 | Cystic fibrosis, unspecified |
| Cystic fibrosis with homozyg f508del mutation in CFTR | |
| E84 | Cystic fibrosis |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.9 | Cystic fibrosis, unspecified |
| Cystic fibrosis with r117H mutation in CFTR gene | |
| E84 | Cystic fibrosis |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.9 | Cystic fibrosis, unspecified |
| 0-9 | A-Z |
|---|---|
| E84 | Cystic fibrosis |
| E84 | Cystic fibrosis |
| E84 | Cystic fibrosis |
| E84 | Cystic fibrosis |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.0 | Cystic fibrosis with pulmonary manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.1 | Cystic fibrosis with intestinal manifestations |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.11 | Meconium ileus in cystic fibrosis |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.19 | Cystic fibrosis with other intestinal manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.8 | Cystic fibrosis with other manifestations |
| E84.9 | Cystic fibrosis, unspecified |
| E84.9 | Cystic fibrosis, unspecified |
| E84.9 | Cystic fibrosis, unspecified |
| E84.9 | Cystic fibrosis, unspecified |
Formulary Reference Tool