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COPIKTRA (duvelisib)
- Chronic lymphocytic leukemia
- Relapsed follicular b-cell non-hodgkin lymphoma
- Small lymphocytic lymphoma
15 mg capsule
- 1 capsule (15 mg) by oral route 2 times per day
25 mg capsule
- 1 capsule (25 mg) by oral route 2 times per day
Chronic lymphocytic leukemia
- 1 capsule (15 mg) by oral route 2 times per day
- 1 capsule (25 mg) by oral route 2 times per day
Relapsed follicular b-cell non-hodgkin lymphoma
- 1 capsule (15 mg) by oral route 2 times per day
- 1 capsule (25 mg) by oral route 2 times per day
Small lymphocytic lymphoma
- 1 capsule (15 mg) by oral route 2 times per day
- 1 capsule (25 mg) by oral route 2 times per day
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Juxtapid
- lomitapide
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Bosulif
- bosutinib
- clozapine
- Clozaril
- colchicine
- colchicine-probenecid
- Colcrys
- deferiprone
- Fazaclo
- Ferriprox
- guanfacine
- ibrutinib
- Imbruvica
- Intuniv Er
- Olysio
- Orap
- pimozide
- Samsca
- simeprevir
- Tenex
- tolvaptan
- Versacloz
Severe
Moderate
- Abstral
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- avanafil
- bosentan
- cilostazol
- Duragesic
- Endocet
- Endodan
- eplerenone
- everolimus
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- ibuprofen-oxycodone
- Inspra
- ivacaftor
- Kalydeco
- Lazanda
- Levitra
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Pletal
- Primlev
- Roxicet
- Stendra
- Sublimaze (pf)
- Subsys
- Tracleer
- vardenafil
- Xartemis Xr
- Zortress
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Interstitial pneumonitis
- Neutropenic disorder
- Pregnancy
- Severe infection
Severe
Moderate
- Colitis
COPIKTRA (duvelisib)
- Chronic lymphocytic leukemia
- Relapsed follicular b-cell non-hodgkin lymphoma
- Small lymphocytic lymphoma
- Anemia
- Colitis
- Diarrhea
- Increased alanine transaminase
- Increased aspartate transaminase
- Infection
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Pneumonia
- Cough
- Fatigue
- Fever
- Musculoskeletal pain
- Nausea
- Skin rash
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Cytomegalovirus disease
- Elevated serum lipase
- Exfoliative dermatitis
- Hyperkalemia
- Hypocalcemia
- Hypokalemia
- Hyponatremia
- Interstitial pneumonitis
- Lower respiratory infection
- Lymphocytosis
- Lymphopenia
- Maculopapular rash
- Pneumocystis jirovecii pneumonia
- Sepsis
- Thrombocytopenic disorder
- Acute abdominal pain
- Anorexia
- Arthralgias
- Constipation
- Dyspnea
- Edema
- Headache disorder
- Stomatitis
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- DRESS syndrome
- Toxic epidermal necrolysis
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Duvelisib
No safety and efficacy established in pediatric patients.
- 1 Day – 18 Years
- No safety and efficacy established in pediatric patients.
Duvelisib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Duvelisib
None
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | None |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Get medical help right away if you have any signs of infection (such as sore throat that doesn't go away, fever, swollen lymph nodes, chills, cough).<br /><br /> This medication has caused serious (even fatal) bowel problems (such as diarrhea, colitis). Tell your doctor right away if you have new or worsening diarrhea, or stool with blood/mucus. Duvelisib can commonly cause a rash that is usually not serious.<br /><br />However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Tell your doctor right away if you develop any rash. This medication can cause serious (even fatal) inflammation of your lungs. Tell your doctor right away if you develop new or worsening cough or trouble breathing.
Chronic lymphocytic leukemia | |
C91.1 | Chronic lymphocytic leukemia of b-cell type |
C91.10 | Chronic lymphocytic leukemia of b-cell type not having achieved remission |
C91.12 | Chronic lymphocytic leukemia of b-cell type in relapse |
Relapsed follicular b-cell non-hodgkin lymphoma | |
C82 | Follicular lymphoma |
C82.0 | Follicular lymphoma grade I |
C82.00 | Follicular lymphoma grade i, unspecified site |
C82.01 | Follicular lymphoma grade i, lymph nodes of head, face, and neck |
C82.02 | Follicular lymphoma grade i, intrathoracic lymph nodes |
C82.03 | Follicular lymphoma grade i, intra-abdominal lymph nodes |
C82.04 | Follicular lymphoma grade i, lymph nodes of axilla and upper limb |
C82.05 | Follicular lymphoma grade i, lymph nodes of inguinal region and lower limb |
C82.06 | Follicular lymphoma grade i, intrapelvic lymph nodes |
C82.07 | Follicular lymphoma grade i, spleen |
C82.08 | Follicular lymphoma grade i, lymph nodes of multiple sites |
C82.09 | Follicular lymphoma grade i, extranodal and solid organ sites |
C82.1 | Follicular lymphoma grade II |
C82.10 | Follicular lymphoma grade Ii, unspecified site |
C82.11 | Follicular lymphoma grade Ii, lymph nodes of head, face, and neck |
C82.12 | Follicular lymphoma grade Ii, intrathoracic lymph nodes |
C82.13 | Follicular lymphoma grade Ii, intra-abdominal lymph nodes |
C82.14 | Follicular lymphoma grade Ii, lymph nodes of axilla and upper limb |
C82.15 | Follicular lymphoma grade Ii, lymph nodes of inguinal region and lower limb |
C82.16 | Follicular lymphoma grade Ii, intrapelvic lymph nodes |
C82.17 | Follicular lymphoma grade Ii, spleen |
C82.18 | Follicular lymphoma grade Ii, lymph nodes of multiple sites |
C82.19 | Follicular lymphoma grade Ii, extranodal and solid organ sites |
C82.2 | Follicular lymphoma grade IIi, unspecified |
C82.20 | Follicular lymphoma grade IIi, unspecified, unspecified site |
C82.21 | Follicular lymphoma grade IIi, unspecified, lymph nodes of head, face, and neck |
C82.22 | Follicular lymphoma grade IIi, unspecified, intrathoracic lymph nodes |
C82.23 | Follicular lymphoma grade IIi, unspecified, intra-abdominal lymph nodes |
C82.24 | Follicular lymphoma grade IIi, unspecified, lymph nodes of axilla and upper limb |
C82.25 | Follicular lymphoma grade IIi, unspecified, lymph nodes of inguinal region and lower limb |
C82.26 | Follicular lymphoma grade IIi, unspecified, intrapelvic lymph nodes |
C82.27 | Follicular lymphoma grade IIi, unspecified, spleen |
C82.28 | Follicular lymphoma grade IIi, unspecified, lymph nodes of multiple sites |
C82.29 | Follicular lymphoma grade IIi, unspecified, extranodal and solid organ sites |
C82.3 | Follicular lymphoma grade IIia |
C82.30 | Follicular lymphoma grade IIia, unspecified site |
C82.31 | Follicular lymphoma grade IIia, lymph nodes of head, face, and neck |
C82.32 | Follicular lymphoma grade IIia, intrathoracic lymph nodes |
C82.33 | Follicular lymphoma grade IIia, intra-abdominal lymph nodes |
C82.34 | Follicular lymphoma grade IIia, lymph nodes of axilla and upper limb |
C82.35 | Follicular lymphoma grade IIia, lymph nodes of inguinal region and lower limb |
C82.36 | Follicular lymphoma grade IIia, intrapelvic lymph nodes |
C82.37 | Follicular lymphoma grade IIia, spleen |
C82.38 | Follicular lymphoma grade IIia, lymph nodes of multiple sites |
C82.39 | Follicular lymphoma grade IIia, extranodal and solid organ sites |
C82.4 | Follicular lymphoma grade IIib |
C82.40 | Follicular lymphoma grade IIib, unspecified site |
C82.41 | Follicular lymphoma grade IIib, lymph nodes of head, face, and neck |
C82.42 | Follicular lymphoma grade IIib, intrathoracic lymph nodes |
C82.43 | Follicular lymphoma grade IIib, intra-abdominal lymph nodes |
C82.44 | Follicular lymphoma grade IIib, lymph nodes of axilla and upper limb |
C82.45 | Follicular lymphoma grade IIib, lymph nodes of inguinal region and lower limb |
C82.46 | Follicular lymphoma grade IIib, intrapelvic lymph nodes |
C82.47 | Follicular lymphoma grade IIib, spleen |
C82.48 | Follicular lymphoma grade IIib, lymph nodes of multiple sites |
C82.49 | Follicular lymphoma grade IIib, extranodal and solid organ sites |
C82.5 | Diffuse follicle center lymphoma |
C82.50 | Diffuse follicle center lymphoma, unspecified site |
C82.51 | Diffuse follicle center lymphoma, lymph nodes of head, face, and neck |
C82.52 | Diffuse follicle center lymphoma, intrathoracic lymph nodes |
C82.53 | Diffuse follicle center lymphoma, intra-abdominal lymph nodes |
C82.54 | Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.55 | Diffuse follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.56 | Diffuse follicle center lymphoma, intrapelvic lymph nodes |
C82.57 | Diffuse follicle center lymphoma, spleen |
C82.58 | Diffuse follicle center lymphoma, lymph nodes of multiple sites |
C82.59 | Diffuse follicle center lymphoma, extranodal and solid organ sites |
C82.6 | Cutaneous follicle center lymphoma |
C82.60 | Cutaneous follicle center lymphoma, unspecified site |
C82.61 | Cutaneous follicle center lymphoma, lymph nodes of head, face, and neck |
C82.62 | Cutaneous follicle center lymphoma, intrathoracic lymph nodes |
C82.63 | Cutaneous follicle center lymphoma, intra-abdominal lymph nodes |
C82.64 | Cutaneous follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.65 | Cutaneous follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.66 | Cutaneous follicle center lymphoma, intrapelvic lymph nodes |
C82.67 | Cutaneous follicle center lymphoma, spleen |
C82.68 | Cutaneous follicle center lymphoma, lymph nodes of multiple sites |
C82.69 | Cutaneous follicle center lymphoma, extranodal and solid organ sites |
C82.8 | Other types of follicular lymphoma |
C82.80 | Other types of follicular lymphoma, unspecified site |
C82.81 | Other types of follicular lymphoma, lymph nodes of head, face, and neck |
C82.82 | Other types of follicular lymphoma, intrathoracic lymph nodes |
C82.83 | Other types of follicular lymphoma, intra-abdominal lymph nodes |
C82.84 | Other types of follicular lymphoma, lymph nodes of axilla and upper limb |
C82.85 | Other types of follicular lymphoma, lymph nodes of inguinal region and lower limb |
C82.86 | Other types of follicular lymphoma, intrapelvic lymph nodes |
C82.87 | Other types of follicular lymphoma, spleen |
C82.88 | Other types of follicular lymphoma, lymph nodes of multiple sites |
C82.89 | Other types of follicular lymphoma, extranodal and solid organ sites |
C82.9 | Follicular lymphoma, unspecified |
C82.90 | Follicular lymphoma, unspecified, unspecified site |
C82.91 | Follicular lymphoma, unspecified, lymph nodes of head, face, and neck |
C82.92 | Follicular lymphoma, unspecified, intrathoracic lymph nodes |
C82.93 | Follicular lymphoma, unspecified, intra-abdominal lymph nodes |
C82.94 | Follicular lymphoma, unspecified, lymph nodes of axilla and upper limb |
C82.95 | Follicular lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
C82.96 | Follicular lymphoma, unspecified, intrapelvic lymph nodes |
C82.97 | Follicular lymphoma, unspecified, spleen |
C82.98 | Follicular lymphoma, unspecified, lymph nodes of multiple sites |
C82.99 | Follicular lymphoma, unspecified, extranodal and solid organ sites |
Small lymphocytic lymphoma | |
C83.0 | Small cell b-cell lymphoma |
C83.00 | Small cell b-cell lymphoma, unspecified site |
C83.01 | Small cell b-cell lymphoma, lymph nodes of head, face, and neck |
C83.02 | Small cell b-cell lymphoma, intrathoracic lymph nodes |
C83.03 | Small cell b-cell lymphoma, intra-abdominal lymph nodes |
C83.04 | Small cell b-cell lymphoma, lymph nodes of axilla and upper limb |
C83.05 | Small cell b-cell lymphoma, lymph nodes of inguinal region and lower limb |
C83.06 | Small cell b-cell lymphoma, intrapelvic lymph nodes |
C83.07 | Small cell b-cell lymphoma, spleen |
C83.08 | Small cell b-cell lymphoma, lymph nodes of multiple sites |
C83.09 | Small cell b-cell lymphoma, extranodal and solid organ sites |
0-9 | A-Z |
---|---|
C82 | Follicular lymphoma |
C82.0 | Follicular lymphoma grade I |
C82.00 | Follicular lymphoma grade i, unspecified site |
C82.01 | Follicular lymphoma grade i, lymph nodes of head, face, and neck |
C82.02 | Follicular lymphoma grade i, intrathoracic lymph nodes |
C82.03 | Follicular lymphoma grade i, intra-abdominal lymph nodes |
C82.04 | Follicular lymphoma grade i, lymph nodes of axilla and upper limb |
C82.05 | Follicular lymphoma grade i, lymph nodes of inguinal region and lower limb |
C82.06 | Follicular lymphoma grade i, intrapelvic lymph nodes |
C82.07 | Follicular lymphoma grade i, spleen |
C82.08 | Follicular lymphoma grade i, lymph nodes of multiple sites |
C82.09 | Follicular lymphoma grade i, extranodal and solid organ sites |
C82.1 | Follicular lymphoma grade II |
C82.10 | Follicular lymphoma grade Ii, unspecified site |
C82.11 | Follicular lymphoma grade Ii, lymph nodes of head, face, and neck |
C82.12 | Follicular lymphoma grade Ii, intrathoracic lymph nodes |
C82.13 | Follicular lymphoma grade Ii, intra-abdominal lymph nodes |
C82.14 | Follicular lymphoma grade Ii, lymph nodes of axilla and upper limb |
C82.15 | Follicular lymphoma grade Ii, lymph nodes of inguinal region and lower limb |
C82.16 | Follicular lymphoma grade Ii, intrapelvic lymph nodes |
C82.17 | Follicular lymphoma grade Ii, spleen |
C82.18 | Follicular lymphoma grade Ii, lymph nodes of multiple sites |
C82.19 | Follicular lymphoma grade Ii, extranodal and solid organ sites |
C82.2 | Follicular lymphoma grade IIi, unspecified |
C82.20 | Follicular lymphoma grade IIi, unspecified, unspecified site |
C82.21 | Follicular lymphoma grade IIi, unspecified, lymph nodes of head, face, and neck |
C82.22 | Follicular lymphoma grade IIi, unspecified, intrathoracic lymph nodes |
C82.23 | Follicular lymphoma grade IIi, unspecified, intra-abdominal lymph nodes |
C82.24 | Follicular lymphoma grade IIi, unspecified, lymph nodes of axilla and upper limb |
C82.25 | Follicular lymphoma grade IIi, unspecified, lymph nodes of inguinal region and lower limb |
C82.26 | Follicular lymphoma grade IIi, unspecified, intrapelvic lymph nodes |
C82.27 | Follicular lymphoma grade IIi, unspecified, spleen |
C82.28 | Follicular lymphoma grade IIi, unspecified, lymph nodes of multiple sites |
C82.29 | Follicular lymphoma grade IIi, unspecified, extranodal and solid organ sites |
C82.3 | Follicular lymphoma grade IIia |
C82.30 | Follicular lymphoma grade IIia, unspecified site |
C82.31 | Follicular lymphoma grade IIia, lymph nodes of head, face, and neck |
C82.32 | Follicular lymphoma grade IIia, intrathoracic lymph nodes |
C82.33 | Follicular lymphoma grade IIia, intra-abdominal lymph nodes |
C82.34 | Follicular lymphoma grade IIia, lymph nodes of axilla and upper limb |
C82.35 | Follicular lymphoma grade IIia, lymph nodes of inguinal region and lower limb |
C82.36 | Follicular lymphoma grade IIia, intrapelvic lymph nodes |
C82.37 | Follicular lymphoma grade IIia, spleen |
C82.38 | Follicular lymphoma grade IIia, lymph nodes of multiple sites |
C82.39 | Follicular lymphoma grade IIia, extranodal and solid organ sites |
C82.4 | Follicular lymphoma grade IIib |
C82.40 | Follicular lymphoma grade IIib, unspecified site |
C82.41 | Follicular lymphoma grade IIib, lymph nodes of head, face, and neck |
C82.42 | Follicular lymphoma grade IIib, intrathoracic lymph nodes |
C82.43 | Follicular lymphoma grade IIib, intra-abdominal lymph nodes |
C82.44 | Follicular lymphoma grade IIib, lymph nodes of axilla and upper limb |
C82.45 | Follicular lymphoma grade IIib, lymph nodes of inguinal region and lower limb |
C82.46 | Follicular lymphoma grade IIib, intrapelvic lymph nodes |
C82.47 | Follicular lymphoma grade IIib, spleen |
C82.48 | Follicular lymphoma grade IIib, lymph nodes of multiple sites |
C82.49 | Follicular lymphoma grade IIib, extranodal and solid organ sites |
C82.5 | Diffuse follicle center lymphoma |
C82.50 | Diffuse follicle center lymphoma, unspecified site |
C82.51 | Diffuse follicle center lymphoma, lymph nodes of head, face, and neck |
C82.52 | Diffuse follicle center lymphoma, intrathoracic lymph nodes |
C82.53 | Diffuse follicle center lymphoma, intra-abdominal lymph nodes |
C82.54 | Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.55 | Diffuse follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.56 | Diffuse follicle center lymphoma, intrapelvic lymph nodes |
C82.57 | Diffuse follicle center lymphoma, spleen |
C82.58 | Diffuse follicle center lymphoma, lymph nodes of multiple sites |
C82.59 | Diffuse follicle center lymphoma, extranodal and solid organ sites |
C82.6 | Cutaneous follicle center lymphoma |
C82.60 | Cutaneous follicle center lymphoma, unspecified site |
C82.61 | Cutaneous follicle center lymphoma, lymph nodes of head, face, and neck |
C82.62 | Cutaneous follicle center lymphoma, intrathoracic lymph nodes |
C82.63 | Cutaneous follicle center lymphoma, intra-abdominal lymph nodes |
C82.64 | Cutaneous follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.65 | Cutaneous follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.66 | Cutaneous follicle center lymphoma, intrapelvic lymph nodes |
C82.67 | Cutaneous follicle center lymphoma, spleen |
C82.68 | Cutaneous follicle center lymphoma, lymph nodes of multiple sites |
C82.69 | Cutaneous follicle center lymphoma, extranodal and solid organ sites |
C82.8 | Other types of follicular lymphoma |
C82.80 | Other types of follicular lymphoma, unspecified site |
C82.81 | Other types of follicular lymphoma, lymph nodes of head, face, and neck |
C82.82 | Other types of follicular lymphoma, intrathoracic lymph nodes |
C82.83 | Other types of follicular lymphoma, intra-abdominal lymph nodes |
C82.84 | Other types of follicular lymphoma, lymph nodes of axilla and upper limb |
C82.85 | Other types of follicular lymphoma, lymph nodes of inguinal region and lower limb |
C82.86 | Other types of follicular lymphoma, intrapelvic lymph nodes |
C82.87 | Other types of follicular lymphoma, spleen |
C82.88 | Other types of follicular lymphoma, lymph nodes of multiple sites |
C82.89 | Other types of follicular lymphoma, extranodal and solid organ sites |
C82.9 | Follicular lymphoma, unspecified |
C82.90 | Follicular lymphoma, unspecified, unspecified site |
C82.91 | Follicular lymphoma, unspecified, lymph nodes of head, face, and neck |
C82.92 | Follicular lymphoma, unspecified, intrathoracic lymph nodes |
C82.93 | Follicular lymphoma, unspecified, intra-abdominal lymph nodes |
C82.94 | Follicular lymphoma, unspecified, lymph nodes of axilla and upper limb |
C82.95 | Follicular lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
C82.96 | Follicular lymphoma, unspecified, intrapelvic lymph nodes |
C82.97 | Follicular lymphoma, unspecified, spleen |
C82.98 | Follicular lymphoma, unspecified, lymph nodes of multiple sites |
C82.99 | Follicular lymphoma, unspecified, extranodal and solid organ sites |
C83.0 | Small cell b-cell lymphoma |
C83.00 | Small cell b-cell lymphoma, unspecified site |
C83.01 | Small cell b-cell lymphoma, lymph nodes of head, face, and neck |
C83.02 | Small cell b-cell lymphoma, intrathoracic lymph nodes |
C83.03 | Small cell b-cell lymphoma, intra-abdominal lymph nodes |
C83.04 | Small cell b-cell lymphoma, lymph nodes of axilla and upper limb |
C83.05 | Small cell b-cell lymphoma, lymph nodes of inguinal region and lower limb |
C83.06 | Small cell b-cell lymphoma, intrapelvic lymph nodes |
C83.07 | Small cell b-cell lymphoma, spleen |
C83.08 | Small cell b-cell lymphoma, lymph nodes of multiple sites |
C83.09 | Small cell b-cell lymphoma, extranodal and solid organ sites |
C91.1 | Chronic lymphocytic leukemia of b-cell type |
C91.10 | Chronic lymphocytic leukemia of b-cell type not having achieved remission |
C91.12 | Chronic lymphocytic leukemia of b-cell type in relapse |
Formulary Reference Tool