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ZYLET (TOBRAMYCIN/LOTEPREDNOL ETABONATE)
- Ocular inflammation
- Superficial ocular infection
0.3 %-0.5 % eye drops,suspension
- Dosage information is not available
Ocular inflammation
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 6 hours
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into left eye by ophthalmic route every 6 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4-6 hours
- Instill 2 drops into right eye by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4-6 hours
- Instill 2 drops into left eye by ophthalmic route every 4-6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4-6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4-6 hours
Superficial ocular infection
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 6 hours
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into left eye by ophthalmic route every 6 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 6 hours
- Instill 1 drop into right eye by ophthalmic route every 4-6 hours
- Instill 2 drops into right eye by ophthalmic route every 4-6 hours
- Instill 1 drop into left eye by ophthalmic route every 4-6 hours
- Instill 2 drops into left eye by ophthalmic route every 4-6 hours
- Instill 1 drop into both eyes by ophthalmic route every 4-6 hours
- Instill 2 drops into both eyes by ophthalmic route every 4-6 hours
- None
Contraindicated
- None
Severe
Moderate
- None
- Fungal infection of eye
- Herpes simplex dendritic keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
Contraindicated
- Glaucoma
- Ocular hypertension
Severe
Moderate
- No disease contraindications
ZYLET (TOBRAMYCIN/LOTEPREDNOL ETABONATE)
- Ocular inflammation
- Superficial ocular infection
- Chemosis
- Anterior chamber inflammation
- Blurred vision
- Dry eye
- Eye tearing
- Headache disorder
- Ocular itching
- Ocular pain
- Ocular redness
- Pharyngitis
- Photophobia
- Rhinitis
- Visual changes
More Frequent
Severe
Less Severe
- Disorder of cornea
- Keratoconjunctivitis
- Ocular inflammation
- Ocular itching
- Ocular redness
- Uveitis
- Blurred vision
- Conjunctivitis
- Eyelid erythema
- Ocular discharge
- Ocular hypertension
- Ocular irritation
- Ocular pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Bacterial eye infection
- Cataracts
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Impaired wound healing
- Ocular infection
- Punctate keratitis
- Viral ocular infection
Less Severe
- Eyelid edema
- Foreign body sensation of eye
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tobramycin (Ophth)
Safety and efficacy below the age of 2 months not established.
- 1 Day – 59 Days
- Safety and efficacy below the age of 2 months not established.
Loteprednol
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Tobramycin Sulfate (ophthalmic)
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Loteprednol
Insuff data; systemic absorption unknown; potential for adverse effect in inf
Poor oral absorption; unlikely clinically significant levels in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data; systemic absorption unknown; potential for adverse effect in inf |
Tobramycin
Insuff data; systemic absorption unknown; potential for adverse effect in inf
Poor oral absorption; unlikely clinically significant levels in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Poor oral absorption; unlikely clinically significant levels in infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Ocular inflammation | |
| H57.8 | Other specified disorders of eye and adnexa |
| Superficial ocular infection | |
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| 0-9 | A-Z |
|---|---|
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H57.8 | Other specified disorders of eye and adnexa |
Formulary Reference Tool