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NEOMYCIN-POLYMYXIN-HYDROCORT (NEOMYCIN SULFATE/POLYMYXIN B SULFATE/HYDROCORTISONE)
- Otitis externa
- Mastoidectomy cavity infections
3.5 mg/mL-10,000 unit/mL-1 % ear solution
- Instill 4 drops into affected ear(s) by otic route 3 times per day
neomycin-polymyxin-hydrocort 3.5 mg/mL-10,000 unit/mL-1 % ear solution
- Instill 4 drops into affected ear(s) by otic route 3 times per day
neomycin-polymyxin-hydrocort 3.5 mg/mL-10,000 unit/mL-1 % ear solution
- Instill 4 drops into affected ear(s) by otic route 3 times per day
Chronic suppurative otitis media
- Instill 4 drops into left ear by otic route every 6 hours
- Instill 4 drops into left ear by otic route every 6 hours for 10 days
- Instill 4 drops into right ear by otic route every 6 hours
- Instill 4 drops into right ear by otic route every 6 hours for 10 days
- Instill 4 drops into both ears by otic route every 6 hours
- Instill 4 drops into both ears by otic route every 6 hours for 10 days
- Instill 4 drops into left ear by otic route every 8 hours
- Instill 4 drops into left ear by otic route every 8 hours for 10 days
- Instill 4 drops into right ear by otic route every 8 hours
- Instill 4 drops into right ear by otic route every 8 hours for 10 days
- Instill 4 drops into both ears by otic route every 8 hours
- Instill 4 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 6 hours
- Instill 10 drops into left ear by otic route every 6 hours for 10 days
- Instill 10 drops into right ear by otic route every 6 hours
- Instill 10 drops into right ear by otic route every 6 hours for 10 days
- Instill 10 drops into both ears by otic route every 6 hours
- Instill 10 drops into both ears by otic route every 6 hours for 10 days
- Instill 10 drops into left ear by otic route every 8 hours
- Instill 10 drops into left ear by otic route every 8 hours for 10 days
- Instill 10 drops into right ear by otic route every 8 hours
- Instill 10 drops into right ear by otic route every 8 hours for 10 days
- Instill 10 drops into both ears by otic route every 8 hours
- Instill 10 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 8 hours for10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours
- Instill 10 drops into affected ear(s) by otic route every 8 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours
- Instill 10 drops into affected ear(s) by otic route every 6 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 6 hours for10 days
Mastoidectomy cavity infections
- Instill 4 drops into left ear by otic route every 6 hours
- Instill 4 drops into left ear by otic route every 6 hours for 10 days
- Instill 4 drops into right ear by otic route every 6 hours
- Instill 4 drops into right ear by otic route every 6 hours for 10 days
- Instill 4 drops into both ears by otic route every 6 hours
- Instill 4 drops into both ears by otic route every 6 hours for 10 days
- Instill 4 drops into left ear by otic route every 8 hours
- Instill 4 drops into left ear by otic route every 8 hours for 10 days
- Instill 4 drops into right ear by otic route every 8 hours
- Instill 4 drops into right ear by otic route every 8 hours for 10 days
- Instill 4 drops into both ears by otic route every 8 hours
- Instill 4 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 6 hours
- Instill 10 drops into left ear by otic route every 6 hours for 10 days
- Instill 10 drops into right ear by otic route every 6 hours
- Instill 10 drops into right ear by otic route every 6 hours for 10 days
- Instill 10 drops into both ears by otic route every 6 hours
- Instill 10 drops into both ears by otic route every 6 hours for 10 days
- Instill 10 drops into left ear by otic route every 8 hours
- Instill 10 drops into left ear by otic route every 8 hours for 10 days
- Instill 10 drops into right ear by otic route every 8 hours
- Instill 10 drops into right ear by otic route every 8 hours for 10 days
- Instill 10 drops into both ears by otic route every 8 hours
- Instill 10 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 8 hours for10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours
- Instill 10 drops into affected ear(s) by otic route every 8 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours
- Instill 10 drops into affected ear(s) by otic route every 6 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 6 hours for10 days
Otitis externa
- Instill 4 drops into right ear by otic route 3 times per day
- Instill 4 drops into left ear by otic route 3 times per day
- Instill 4 drops into right ear by otic route 4 times per day
- Instill 4 drops into left ear by otic route 4 times per day
- Instill 4 drops into both ears by otic route 3 times per day
- Instill 4 drops into both ears by otic route 4 times per day
- Instill 4 drops into left ear by otic route 3 times per day for 10 days
- Instill 4 drops into right ear by otic route 3 times per day for 10 days
- Instill 4 drops into both ears by otic route 3 times per day for 10 days
- Instill 4 drops into left ear by otic route 4 times per day for 10 days
- Instill 4 drops into right ear by otic route 4 times per day for 10 days
- Instill 4 drops into affected ear(s) by otic route 3 times per day
- Instill 4 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route 3 times per day for 10 days
- Instill 4 drops into affected ear(s) by otic route 4 times per day for 10 days
- None
Contraindicated
- None
Severe
Moderate
- bumetanide
- Demadex
- ethacrynate sodium
- furosemide
- Lasix
- Sodium Edecrin
- torsemide
- None
Contraindicated
- Bullous myringitis
- Fungal infection in the ear
- Herpes simplex infection
- Herpes zoster oticus
- Tuberculosis of the ear
- Viral infection in the ear
Severe
Moderate
- No disease contraindications
- Perforated eardrum
NEOMYCIN-POLYMYXIN-HYDROCORT (NEOMYCIN SULFATE/POLYMYXIN B SULFATE/HYDROCORTISONE)
- Otitis externa
- Mastoidectomy cavity infections
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- None
Less Severe
- Ear stinging
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Aminoglycosides (Otic)
Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
- 1 Day – 6 Years
- Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
Hydrocortisone (topical, Non-systemic)
- Severity Level:
2
- Additional Notes: Systemic absorption unknown; insuff human data
Neomycin (otic)
- Severity Level:
C
- Additional Notes: Fda cat c in combination otic products
Polymyxin B Sulfate (ophth,otic,top)
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Hydrocortisone (sys)
Insufficient data available; normal constituent of breastmilk
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Insufficient data available; normal constituent of breastmilk |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Mastoidectomy cavity infections | |
| H95.19 | Other disorders following mastoidectomy |
| H95.191 | Other disorders following mastoidectomy, right ear |
| H95.192 | Other disorders following mastoidectomy, left ear |
| H95.193 | Other disorders following mastoidectomy, bilateral ears |
| H95.199 | Other disorders following mastoidectomy, unspecified ear |
| Otitis externa | |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| 0-9 | A-Z |
|---|---|
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| H95.19 | Other disorders following mastoidectomy |
| H95.191 | Other disorders following mastoidectomy, right ear |
| H95.192 | Other disorders following mastoidectomy, left ear |
| H95.193 | Other disorders following mastoidectomy, bilateral ears |
| H95.199 | Other disorders following mastoidectomy, unspecified ear |
Formulary Reference Tool