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NEOMYCIN-POLYMYXIN-HC (NEOMYCIN SULFATE/POLYMYXIN B SULFATE/HYDROCORTISONE)
- Otitis externa
- Superficial ocular infection
- Mastoidectomy cavity infections
- Neomycin-polymyxin-hydrocort Eye Drops,suspension
- Neomycin-polymyxin-hydrocort Ear Drops,suspension
- Neomycin-polymyxin-hc Eye Drops, Susp
- Neomycin-polymyxin-hc Ear Drops, Susp
- By Indication
neomycin 3.5 mg-polymyxin 10,000 unit-hydrocort 10 mg/mL eye drop,susp
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
neomycin-polymyxin-hydrocort 3.5 mg-10,000 unit/mL-1 % ear drops,susp
- Instill 4 drops into affected ear(s) by otic route 3 times per day
neomycin 3.5 mg-polymyxin 10,000 unit-hydrocort 10 mg/mL eye drop,susp
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
neomycin-polymyxin-hydrocort 3.5 mg-10,000 unit/mL-1 % ear drops,susp
- Instill 4 drops into affected ear(s) by otic route 3 times per day
Chronic suppurative otitis media
- Instill 4 drops into left ear by otic route every 6 hours
- Instill 4 drops into left ear by otic route every 6 hours for 10 days
- Instill 4 drops into right ear by otic route every 6 hours
- Instill 4 drops into right ear by otic route every 6 hours for 10 days
- Instill 4 drops into both ears by otic route every 6 hours
- Instill 4 drops into both ears by otic route every 6 hours for 10 days
- Instill 4 drops into left ear by otic route every 8 hours
- Instill 4 drops into left ear by otic route every 8 hours for 10 days
- Instill 4 drops into right ear by otic route every 8 hours
- Instill 4 drops into right ear by otic route every 8 hours for 10 days
- Instill 4 drops into both ears by otic route every 8 hours
- Instill 4 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 8 hours
- Instill 10 drops into left ear by otic route every 8 hours for 10 days
- Instill 10 drops into right ear by otic route every 8 hours
- Instill 10 drops into right ear by otic route every 8 hours for 10 days
- Instill 10 drops into both ears by otic route every 8 hours
- Instill 10 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 6 hours
- Instill 10 drops into left ear by otic route every 6 hours for 10 days
- Instill 10 drops into right ear by otic route every 6 hours
- Instill 10 drops into right ear by otic route every 6 hours for 10 days
- Instill 10 drops into both ears by otic route every 6 hours
- Instill 10 drops into both ears by otic route every 6 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 8 hours for10 days
- Instill 10 drops into affected ear(s) by otic route every 6 hours for10 days
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route 3 times per day
- Instill 10 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route 3 times per day
- Instill 4 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route every 8 hours
- Instill 10 drops into affected ear(s) by otic route every 8 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours
- Instill 10 drops into affected ear(s) by otic route every 6 hours
Mastoidectomy cavity infections
- Instill 4 drops into left ear by otic route every 6 hours
- Instill 4 drops into left ear by otic route every 6 hours for 10 days
- Instill 4 drops into right ear by otic route every 6 hours
- Instill 4 drops into right ear by otic route every 6 hours for 10 days
- Instill 4 drops into both ears by otic route every 6 hours
- Instill 4 drops into both ears by otic route every 6 hours for 10 days
- Instill 4 drops into left ear by otic route every 8 hours
- Instill 4 drops into left ear by otic route every 8 hours for 10 days
- Instill 4 drops into right ear by otic route every 8 hours
- Instill 4 drops into right ear by otic route every 8 hours for 10 days
- Instill 4 drops into both ears by otic route every 8 hours
- Instill 4 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 8 hours
- Instill 10 drops into left ear by otic route every 8 hours for 10 days
- Instill 10 drops into right ear by otic route every 8 hours
- Instill 10 drops into right ear by otic route every 8 hours for 10 days
- Instill 10 drops into both ears by otic route every 8 hours
- Instill 10 drops into both ears by otic route every 8 hours for 10 days
- Instill 10 drops into left ear by otic route every 6 hours
- Instill 10 drops into left ear by otic route every 6 hours for 10 days
- Instill 10 drops into right ear by otic route every 6 hours
- Instill 10 drops into right ear by otic route every 6 hours for 10 days
- Instill 10 drops into both ears by otic route every 6 hours
- Instill 10 drops into both ears by otic route every 6 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route every 8 hours for10 days
- Instill 10 drops into affected ear(s) by otic route every 6 hours for10 days
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 10 days
- Instill 10 drops into affected ear(s) by otic route 3 times per day
- Instill 10 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route 3 times per day
- Instill 4 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route every 8 hours
- Instill 10 drops into affected ear(s) by otic route every 8 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours
- Instill 10 drops into affected ear(s) by otic route every 6 hours
Otitis externa
- Instill 4 drops into right ear by otic route 3 times per day
- Instill 4 drops into left ear by otic route 3 times per day
- Instill 4 drops into right ear by otic route 4 times per day
- Instill 4 drops into left ear by otic route 4 times per day
- Instill 4 drops into both ears by otic route 3 times per day
- Instill 4 drops into both ears by otic route 4 times per day
- Instill 4 drops into left ear by otic route 3 times per day for 10 days
- Instill 4 drops into right ear by otic route 3 times per day for 10 days
- Instill 4 drops into both ears by otic route 3 times per day for 10 days
- Instill 4 drops into left ear by otic route 4 times per day for 10 days
- Instill 4 drops into right ear by otic route 4 times per day for 10 days
- Instill 4 drops into both ears by otic route 4 times per day for 10 days
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 7 days
- Instill 4 drops into affected ear(s) by otic route every 6 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 7 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours for 10 days
- Instill 4 drops into affected ear(s) by otic route 3 times per day
- Instill 4 drops into affected ear(s) by otic route 4 times per day
- Instill 4 drops into affected ear(s) by otic route 3 times per day for 7 days
- Instill 4 drops into affected ear(s) by otic route 3 times per day for 10 days
- Instill 4 drops into affected ear(s) by otic route 4 times per day for 7 days
- Instill 4 drops into affected ear(s) by otic route 4 times per day for 10 days
- Instill 4 drops into affected ear(s) by otic route every 8 hours
- Instill 4 drops into affected ear(s) by otic route every 6 hours
Superficial ocular infection
- Instill 2 drops into left eye by ophthalmic route every 3 hours
- Instill 2 drops into left eye by ophthalmic route every 4 hours
- Instill 2 drops into right eye by ophthalmic route every 3 hours
- Instill 2 drops into right eye by ophthalmic route every 4 hours
- Instill 2 drops into both eyes by ophthalmic route every 3 hours
- Instill 2 drops into both eyes by ophthalmic route every 4 hours
- Instill 1 drop into left eye by ophthalmic route every 3 hours
- Instill 1 drop into right eye by ophthalmic route every 3 hours
- Instill 1 drop into both eyes by ophthalmic route every 3 hours
- Instill 1 drop into left eye by ophthalmic route every 4 hours
- Instill 1 drop into right eye by ophthalmic route every 4 hours
- Instill 1 drop into both eyes by ophthalmic route every 4 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 3 hours
- Instill 2 drops into affected eye(s) by ophthalmic route every 4 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 3 hours
- Instill 1 drop into affected eye(s) by ophthalmic route every 4 hours
- None
Contraindicated
- None
Severe
Moderate
- bumetanide
- Demadex
- ethacrynate sodium
- furosemide
- Lasix
- Sodium Edecrin
- torsemide
- Amebic infection of the eye
- Herpes simplex dendritic keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
Contraindicated
- Bullous myringitis
- Fungal infection in the ear
- Fungal infection of eye
- Herpes simplex infection
- Herpes zoster ophthalmicus
- Herpes zoster oticus
- Ocular hypertension
- Ocular injury
- Tuberculosis of the ear
- Viral infection in the ear
Severe
Moderate
- Diabetes mellitus
- Krukenberg spindle
- No disease contraindications
- Open angle glaucoma
- Perforated eardrum
- Severe myopia
NEOMYCIN-POLYMYXIN-HC (NEOMYCIN SULFATE/POLYMYXIN B SULFATE/HYDROCORTISONE)
- Otitis externa
- Superficial ocular infection
- Mastoidectomy cavity infections
- Contact dermatitis
- Ocular inflammation
- Ocular itching
- Ocular redness
- Skin rash
- Blurred vision
More Frequent
Severe
Less Severe
- Ocular irritation
- Blurred vision
- Headache disorder
- Iritis
- Ocular irritation
- Ocular pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Cataracts
- Central serous chorioretinopathy
- Corneal degeneration
- Corneal edema
- Corneal erosion
- Corneal ulcer
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Keratitis
- Ocular hypertension
- Punctate keratitis
- Reduced visual acuity
- Uveitis
- Visual changes
- Visual field defect
Less Severe
- Accommodation disorder
- Allergic dermatitis
- Blepharoptosis
- Chemosis
- Conjunctival hyperemia
- Conjunctivitis
- Dizziness
- Dysgeusia
- Ear stinging
- Eye tearing
- Foreign body sensation of eye
- Impaired wound healing
- Mydriasis
- Ocular infection
- Ocular irritation
- Ocular itching
- Ocular redness
- Photophobia
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Aminoglycosides (Otic)
Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
- 1 Day – 6 Years
- Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
- 1 Day – 18 Years
- Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
Hydrocortisone (Top,Ophth,Rect)
Potential for ototoxicity. Avoid use in children with tympanostomy tubes or a perforated tympanic membrane.
Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
- 1 Day – 6 Years
- Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
- 1 Day – 18 Years
- Prolonged or extensive use may lead to systemic absorption; may affect growth rate.
Hydrocortisone (topical, Non-systemic)
- Severity Level:
2
- Additional Notes: Systemic absorption unknown; insuff human data
Neomycin (ophth)
- Severity Level:
C
- Additional Notes: No single ingredient data. fda category c in combination product.
Neomycin (otic)
- Severity Level:
C
- Additional Notes: Fda cat c in combination otic products
Polymyxin B Sulfate (ophth,otic,top)
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Neomycin (topical, Ophth)
Insufficient data available
None
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Polymyxin B
Insufficient data available
None
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | None |
No Known Risk
Hydrocortisone (sys)
Insufficient data available; normal constituent of breastmilk
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Unknown | Not known; no or inclusive data | Insufficient data available; normal constituent of breastmilk |
Contraindicated
None
Precaution Exists
Hydrocortisone (ophth)
Increased risk of diabetes, cataracts, or glaucoma. Frequent ophthalmic exams recommended.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | Y |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Mastoidectomy cavity infections | |
| H95.19 | Other disorders following mastoidectomy |
| H95.191 | Other disorders following mastoidectomy, right ear |
| H95.192 | Other disorders following mastoidectomy, left ear |
| H95.193 | Other disorders following mastoidectomy, bilateral ears |
| H95.199 | Other disorders following mastoidectomy, unspecified ear |
| Otitis externa | |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| Superficial ocular infection | |
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| 0-9 | A-Z |
|---|---|
| H10.0 | Mucopurulent conjunctivitis |
| H10.01 | Acute follicular conjunctivitis |
| H10.011 | Acute follicular conjunctivitis, right eye |
| H10.012 | Acute follicular conjunctivitis, left eye |
| H10.013 | Acute follicular conjunctivitis, bilateral |
| H10.019 | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | Other mucopurulent conjunctivitis |
| H10.021 | Other mucopurulent conjunctivitis, right eye |
| H10.022 | Other mucopurulent conjunctivitis, left eye |
| H10.023 | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | Other mucopurulent conjunctivitis, unspecified eye |
| H60.31 | Diffuse otitis externa |
| H60.311 | Diffuse otitis externa, right ear |
| H60.312 | Diffuse otitis externa, left ear |
| H60.313 | Diffuse otitis externa, bilateral |
| H60.319 | Diffuse otitis externa, unspecified ear |
| H60.33 | Swimmer's ear |
| H60.331 | Swimmer's ear, right ear |
| H60.332 | Swimmer's ear, left ear |
| H60.333 | Swimmer's ear, bilateral |
| H60.339 | Swimmer's ear, unspecified ear |
| H60.60 | Unspecified chronic otitis externa, unspecified ear |
| H60.61 | Unspecified chronic otitis externa, right ear |
| H60.62 | Unspecified chronic otitis externa, left ear |
| H60.63 | Unspecified chronic otitis externa, bilateral |
| H60.9 | Unspecified otitis externa |
| H60.90 | Unspecified otitis externa, unspecified ear |
| H60.91 | Unspecified otitis externa, right ear |
| H60.92 | Unspecified otitis externa, left ear |
| H60.93 | Unspecified otitis externa, bilateral |
| H95.19 | Other disorders following mastoidectomy |
| H95.191 | Other disorders following mastoidectomy, right ear |
| H95.192 | Other disorders following mastoidectomy, left ear |
| H95.193 | Other disorders following mastoidectomy, bilateral ears |
| H95.199 | Other disorders following mastoidectomy, unspecified ear |
Formulary Reference Tool