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ISORDIL TITRADOSE (ISOSORBIDE DINITRATE)
- Prevention of anginal pain in coronary artery disease
5 mg tablet
- 1 tablet (5 mg) by oral route 2 times per day
Prevention of anginal pain in coronary artery disease
- 1 tablet (5 mg) by oral route 3 times per day
- 1 tablet (5 mg) by oral route 2 times per day
- 2 tablets (10 mg) by oral route 2 times per day
- 2 tablets (10 mg) by oral route 3 times per day
- Adcirca
- Adempas
- avanafil
- Cialis
- Levitra
- Revatio
- riociguat
- sildenafil
- Stendra
- tadalafil
- vardenafil
- Viagra
Contraindicated
- bromocriptine
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- methylergonovine
- Migergot
- Migranal
- Parlodel
Severe
Moderate
- None
- None
Contraindicated
- Intracerebral hemorrhage
- Intracranial hypertension
- Methemoglobinemia
- Severe anemia
Severe
Moderate
- Acute myocardial infarction
- Hypertrophic cardiomyopathy
- Hypotension
- Malabsorption states
ISORDIL TITRADOSE (ISOSORBIDE DINITRATE)
- Prevention of anginal pain in coronary artery disease
- Syncope
- Dizziness
- Flushing
- Headache disorder
- Hypotension
- Nervousness
- Orthostatic hypotension
- Paresthesia
More Frequent
Severe
Less Severe
- None
- Nausea
- Palpitations
- Tachycardia
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Allergic dermatitis
- Anaphylaxis
- Blurred vision
- Exfoliative dermatitis
- Methemoglobinemia
- Severe headache disorder
- Xerostomia
Less Severe
- Drowsy
- Dyspnea
- General weakness
- Skin rash
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Isosorbide
No established safety and efficacy.
- 1 Day – 18 Years
- No established safety and efficacy.
Isosorbide Dinitrate
- Severity Level:
C
- Additional Notes: Insufficient human data; animal data suggest developmental toxicity
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Isosorbide Dinitrate
Insuff data avail; molecular wt low enough for possible breastmilk excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; molecular wt low enough for possible breastmilk excretion |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Isosorbide(dinitrate)
Cardiovascular-Elderly may be more sensitive to the hypotensive effects of vasodilation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Prevention of anginal pain in coronary artery disease | |
| I20 | Angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
| 0-9 | A-Z |
|---|---|
| I20 | Angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
Formulary Reference Tool