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ANCOBON (FLUCYTOSINE)
- Candidal urinary tract infection
- Synergy for candida infection
- Synergy for cryptococcal infection
- Systemic candidiasis treatment adjunct
- Systemic cryptococcosis treatment adjunct
250 mg capsule
- 12.5 mg/kg by oral route every 6 hours
500 mg capsule
- 12.5 mg/kg by oral route every 6 hours
250 mg capsule
- 12.5 mg/kg by oral route every 6 hours
500 mg capsule
- 12.5 mg/kg by oral route every 6 hours
Candidal urinary tract infection
- 12.5 mg/kg by oral route every 6 hours
- 25 mg/kg by oral route every 6 hours
- 37.5 mg/kg by oral route every 6 hours
Chromoblastomycosis
- 12.5 mg/kg by oral route every 6 hours
- 25 mg/kg by oral route every 6 hours
- 37.5 mg/kg by oral route every 6 hours
Systemic candidiasis treatment adjunct
- 12.5 mg/kg by oral route every 6 hours
- 37.5 mg/kg by oral route every 6 hours
Systemic cryptococcosis treatment adjunct
- 12.5 mg/kg by oral route every 6 hours
- 37.5 mg/kg by oral route every 6 hours
- None
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Aplastic anemia secondary to drugs
- Bone marrow depression
- Granulocytopenic disorder
- Kidney disease with likely reduction in GFR
- Leukopenia
- Thrombocytopenic disorder
Severe
Moderate
- Abnormal hepatic function tests
- Disease of liver
- Hypokalemia
ANCOBON (FLUCYTOSINE)
- Candidal urinary tract infection
- Synergy for candida infection
- Synergy for cryptococcal infection
- Systemic candidiasis treatment adjunct
- Systemic cryptococcosis treatment adjunct
- Allergic dermatitis
- Anemia
- Hepatitis
- Jaundice
- Leukopenia
- Pruritus of skin
- Skin rash
- Thrombocytopenic disorder
- Acute abdominal pain
- Anorexia
- Diarrhea
- Headache disorder
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Acute confusion
- Hallucinations
- Fatigue
- Fever
- Sedation
- Skin photosensitivity
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Acute respiratory distress syndrome
- Agranulocytosis
- Chest pain
- Duodenal ulcer
- Dyspnea
- Enterocolitis
- Eosinophilia
- Gastrointestinal hemorrhage
- Hepatic necrosis
- Hyperbilirubinemia
- Hypokalemia
- Hypoplastic anemia
- Neutropenic disorder
- Pancytopenia
- Parkinsonism
- Pure red cell aplasia
- Seizure disorder
- Toxic epidermal necrolysis
- Ulcerative colitis
- Urticaria
- Ventricular arrhythmias
Less Severe
- Ataxia
- Drug-induced psychosis
- Hearing loss
- Hypoglycemic disorder
- Paresthesia
- Peripheral neuropathy
- Vertigo
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Flucytosine
- Severity Level:
2
- Additional Notes: Insufficient human data available. assess maternal benefit vs fetal risks
Contraindicated
Flucytosine
Insufficient data available;Risk of immunosuppression in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient data available;Risk of immunosuppression in infant |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Flucytosine
Check CLCr and adjust dose as appropriate. Monitor hematologic, renal and hepatic function and flucytosine levels.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- This medication should be used with increased caution if you have kidney problems. Flucytosine may cause decreased kidney function and liver problems. In addition, this medication may decrease bone marrow function.<br /><br />This serious, possibly life-threatening side effect may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, and cause bleeding problems. Your doctor will check the results of your kidney, liver, and blood tests and adjust your treatment to reduce your risk for these side effects. See also Side Effects section.
| Candidal urinary tract infection | |
| B37.41 | Candidal cystitis and urethritis |
| B37.49 | Other urogenital candidiasis |
| Synergy for candida infection | |
| B37 | Candidiasis |
| B37.1 | Pulmonary candidiasis |
| B37.5 | Candidal meningitis |
| B37.6 | Candidal endocarditis |
| B37.7 | Candidal sepsis |
| B37.81 | Candidal esophagitis |
| B37.82 | Candidal enteritis |
| B37.9 | Candidiasis, unspecified |
| Synergy for cryptococcal infection | |
| B45 | Cryptococcosis |
| B45.0 | Pulmonary cryptococcosis |
| B45.1 | Cerebral cryptococcosis |
| B45.2 | Cutaneous cryptococcosis |
| B45.3 | Osseous cryptococcosis |
| B45.7 | Disseminated cryptococcosis |
| B45.8 | Other forms of cryptococcosis |
| B45.9 | Cryptococcosis, unspecified |
| Systemic candidiasis treatment adjunct | |
| B37.7 | Candidal sepsis |
| Systemic cryptococcosis treatment adjunct | |
| B45.7 | Disseminated cryptococcosis |
| 0-9 | A-Z |
|---|---|
| B37 | Candidiasis |
| B37.1 | Pulmonary candidiasis |
| B37.41 | Candidal cystitis and urethritis |
| B37.49 | Other urogenital candidiasis |
| B37.5 | Candidal meningitis |
| B37.6 | Candidal endocarditis |
| B37.7 | Candidal sepsis |
| B37.7 | Candidal sepsis |
| B37.81 | Candidal esophagitis |
| B37.82 | Candidal enteritis |
| B37.9 | Candidiasis, unspecified |
| B45 | Cryptococcosis |
| B45.0 | Pulmonary cryptococcosis |
| B45.1 | Cerebral cryptococcosis |
| B45.2 | Cutaneous cryptococcosis |
| B45.3 | Osseous cryptococcosis |
| B45.7 | Disseminated cryptococcosis |
| B45.7 | Disseminated cryptococcosis |
| B45.8 | Other forms of cryptococcosis |
| B45.9 | Cryptococcosis, unspecified |
Formulary Reference Tool