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TUSSICAPS (hydrocodone polistirex/chlorpheniramine polistirex)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
10 mg-8 mg capsule,extended release
- 1 capsule by oral route every 12 hours
5 mg-4 mg capsule,extended release
- Dosage information is not available
10 mg-8 mg capsule,extended release
- 1 capsule by oral route every 12 hours
5 mg-4 mg capsule,extended release
- Dosage information is not available
Allergic rhinitis
- 1 capsule by oral route every 12 hours
Cold symptoms
- 1 capsule by oral route every 12 hours
Cough
- 1 capsule by oral route every 12 hours
Nasal congestion
- 1 capsule by oral route every 12 hours
Rhinorrhea
- 1 capsule by oral route every 12 hours
- Azilect
- Depade
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- naltrexone
- naltrexone microspheres
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- Revia
- selegiline HCl
- tranylcypromine
- Vivitrol
- Zelapar
- Zyvox
Contraindicated
- amoxicil-clarithromy-lansopraz
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- clarithromycin
- conivaptan in 5 % dextrose
- Crixivan
- Diflucan
- elvitegr-cobicist-emtric-tenof
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- Incivek
- indinavir
- Invirase
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lopinavir-ritonavir
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- posaconazole
- Prevpac
- ritonavir
- saquinavir mesylate
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- voriconazole
- Xyrem
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- aprepitant
- atazanavir
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- butorphanol tartrate
- Butrans
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- cimetidine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- darunavir
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Emend
- Fanatrex
- fosamprenavir
- fosaprepitant
- gabapentin
- gabapentin enacarbil
- Gleevec
- Gralise
- Gralise 30-day Starter Pack
- Heartburn Relief
- Horizant
- imatinib
- isoniazid-rifamp-pyrazinamide
- Lexiva
- Matzim La
- Multaq
- nalbuphine
- Neurontin
- Prezista
- Reyataz
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Suboxone
- Tagamet Hb
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Zubsolv
- Sleep apnea
Contraindicated
- Acutely deteriorating asthma
- Alcohol intoxication
- Alcohol withdrawal delirium
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Bradycardia
- Cardiac arrhythmia
- Chronic idiopathic constipation
- Coma
- Cor pulmonale
- Debilitation
- Dehydration
- Drug abuse
- Gastrointestinal obstruction
- Gastrointestinal tract surgery
- History of opioid overdose
- Hypotension
- Inflammatory bowel disease
- Intracranial hypertension
- Morbid obesity
- Neoplasm of brain
- Primary adrenocortical insufficiency
- Pulmonary emphysema
- Respiratory depression
- Seizure disorder
- Shock
- Stenosing peptic ulcer
- Suicidal ideation
- Systemic mastocytosis
- Toxic psychosis
- Ulcerative colitis
- Urethral stricture
- Urinary retention
Severe
Moderate
- Acute abdominal pain
- Biliary spasm
- Chronic obstructive pulmonary disease
- Constipation
- Disease of liver
- Drug dependence
- Gallbladder disease
- Hypertension
- Hyperthyroidism
- Kidney disease with reduction in GFR
- Mood changes
- Untreated hypothyroidism
TUSSICAPS (hydrocodone polistirex/chlorpheniramine polistirex)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
- None
- Constipation
- Dizziness
- Drowsy
- General weakness
- Hypotension
- Malaise
- Nausea
- Sedation
- Syncope
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- Angioedema
- Atelectasis
- Bradycardia
- Bronchospastic pulmonary disease
- CNS depression
- Dyspnea
- Laryngeal edema
- Laryngismus
- Pulse changes
- Respiratory depression
- Tachycardia
- Acute abdominal pain
- Acute confusion
- Anorexia
- Arthralgias
- Back pain
- Blurred vision
- Diplopia
- Dysphoric mood
- False sense of well-being
- Fatigue
- Flushing
- Gastroesophageal reflux disease
- Headache disorder
- Hyperhidrosis
- Lethargy
- Mood changes
- Muscle spasm
- Myalgias
- Nervousness
- Night sweats
- Opioid dependence
- Orthostatic hypotension
- Peripheral edema
- Sedation
- Symptoms of anxiety
- Tremor
- Upper respiratory infection
- Ureteral spasm
- Urinary tract infection
- Visual changes
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Adrenal cortical insufficiency
- Allergic dermatitis
- Anaphylaxis
- Biliary spasm
- Blood dyscrasias
- Dehydration
- Depression
- Disorder of adrenal gland
- Extrasystoles
- Female hypogonadism
- Fever
- Hallucinations
- Hearing loss
- Hemolytic anemia
- Hypertension
- Hypokalemia
- Hypotension
- Ileus
- Increased cerebrospinal fluid pressure
- Involuntary muscle movement
- Ischemic colitis
- Male hypogonadism
- Muscle rigidity
- Pancreatitis
- Paralytic ileus
- Seizure disorder
- Skin rash
- Tinnitus
- Urticaria
Less Severe
- Abdominal distension
- Acute abdominal pain
- Acute confusion
- Androgen deficiency
- Anorexia
- Ataxia
- Blurred vision
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dry nose
- Dry throat
- Dysgeusia
- Dysphagia
- Dyspnea
- Dysuria
- Elevated serum amylase
- Erectile dysfunction
- Euphoria
- Excitement
- Fatigue
- Gastrointestinal irritation
- Headache disorder
- Hyperhidrosis
- Infertility
- Insomnia
- Irritability
- Libido changes
- Maculopapular rash
- Malaise
- Migraine
- Musculoskeletal pain
- Neck pain
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Wheezing
- Xerostomia
Contraindicated
Chlorpheniramine (Ext. Release)
Not recommended in children under 12 years unless clinician consultation.
Possible paradoxical CNS excitation. Seizure risk in newborns.
Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 2 Years – 12 Years
- 1 Not recommended in children under 12 years unless clinician consultation.
- 1 Day – 2 Years
- 1 Not recommended in children under 12 years unless clinician consultation.
- 1 Day – 6 Years
- 1 Not recommended in children under 12 years unless clinician consultation.
Chlorpheniramine (Oral)
Not recommended in children under 12 years unless clinician consultation.
Possible paradoxical CNS excitation. Seizure risk in newborns.
Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 2 Years – 12 Years
- 1 Possible paradoxical CNS excitation. Seizure risk in newborns.
- 1 Day – 2 Years
- 1 Possible paradoxical CNS excitation. Seizure risk in newborns.
- 1 Day – 6 Years
- 1 Possible paradoxical CNS excitation. Seizure risk in newborns.
Hydrocodone (Cough-Cold)
Not recommended in children under 12 years unless clinician consultation.
Possible paradoxical CNS excitation. Seizure risk in newborns.
Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 2 Years – 12 Years
- 1 Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 1 Day – 2 Years
- 1 Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 1 Day – 6 Years
- 1 Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
Severe Precaution
Chlorpheniramine
Not recommended in children under 6 years unless clinician consultation.
Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
- 2 Years – 6 Years
- Not recommended in children under 6 years unless clinician consultation.
- 6 Years – 18 Years
- Not recommended in children under 6 years unless clinician consultation.
Hydrocodone (cough-cold)
Not recommended in children under 6 years unless clinician consultation.
Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
- 2 Years – 6 Years
- Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
- 6 Years – 18 Years
- Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
Management or Monitoring Precaution
None
Chlorpheniramine
- Severity Level:
2
- Additional Notes: Insufficient data available; neonate risk of seizures;avoid during 3rd trimester
Hydrocodone
- Severity Level:
C
- Additional Notes: Neonatal withdrawal/resp.depress. w/chronic or high dose; small teratogenic risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Chlorpheniramine
Insufficient data available; may cause sedation and inhibit lactation
Monitor for changes in respiration, gi effects, sedation, feeding patterns
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; may cause sedation and inhibit lactation |
Hydrocodone
Insufficient data available; may cause sedation and inhibit lactation
Monitor for changes in respiration, gi effects, sedation, feeding patterns
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Monitor for changes in respiration, gi effects, sedation, feeding patterns |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal, breathing problems. To lower your risk, your doctor should have you take the smallest dose that works, and take it for the shortest possible time.<br /><br />See also How to Use section for more information about addiction. The risk for severe breathing problems is higher when you start this medication, or if you take the wrong dose or take more of this medication than prescribed. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death.<br /><br /> Also, other medications can affect the removal of this product from your body, which may affect how it works. Be sure you know how to take this product and what other drugs you should avoid taking with it. See also Drug Interactions section.<br /><br />Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get medical help right away.<br /><br /> Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or think you may be pregnant. During pregnancy, this medication is not recommended.<br /><br />It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time.<br /><br />Babies born to mothers who use this drug for a long time may develop severe (possibly fatal) withdrawal symptoms. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
Formulary Reference Tool