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Drug overview for AMMONUL (sodium benzoate/sodium phenylacetate):
Generic name: sodium benzoate/sodium phenylacetate
Drug class: Urea Cycle Disorder Agents
Therapeutic class: Metabolic Modifiers
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
Generic name: sodium benzoate/sodium phenylacetate
Drug class: Urea Cycle Disorder Agents
Therapeutic class: Metabolic Modifiers
No enhanced Introduction information available for this drug.
No enhanced Uses information available for this drug.
DRUG IMAGES
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The following indications for AMMONUL (sodium benzoate/sodium phenylacetate) have been approved by the FDA:
Indications:
Arginase deficiency
Argininosuccinate lyase deficiency
Carbamoyl phosphate synthetase deficiency
Citrullinemia
Hyperammonemia
Isovaleric acidemia
Ornithine carbamoyltransferase deficiency
Professional Synonyms:
Abnormally elevated blood ammonia
Ammonemia
Argininosuccinate synthetase deficiency
Argininosuccinic acid synthetase deficiency
Argininosuccinic aciduria
Arginosuccinic aciduria
ASAL deficiency
ASL deficiency
CAPS deficiency
Carbamoyl-phosphate synthetase deficiency
CPS deficiency
Hyperammonemia due to ornithine transcarbamylase deficiency
Hyperammonemic syndrome
Hyperargininemia
Isovaleryl CoA dehydrogenase deficiency
Isovaleryl-coenzyme A dehydrogenase deficiency
Ornithine transcarbamoylase deficiency
Ornithine transcarbamylase deficiency
Indications:
Arginase deficiency
Argininosuccinate lyase deficiency
Carbamoyl phosphate synthetase deficiency
Citrullinemia
Hyperammonemia
Isovaleric acidemia
Ornithine carbamoyltransferase deficiency
Professional Synonyms:
Abnormally elevated blood ammonia
Ammonemia
Argininosuccinate synthetase deficiency
Argininosuccinic acid synthetase deficiency
Argininosuccinic aciduria
Arginosuccinic aciduria
ASAL deficiency
ASL deficiency
CAPS deficiency
Carbamoyl-phosphate synthetase deficiency
CPS deficiency
Hyperammonemia due to ornithine transcarbamylase deficiency
Hyperammonemic syndrome
Hyperargininemia
Isovaleryl CoA dehydrogenase deficiency
Isovaleryl-coenzyme A dehydrogenase deficiency
Ornithine transcarbamoylase deficiency
Ornithine transcarbamylase deficiency
The following dosing information is available for AMMONUL (sodium benzoate/sodium phenylacetate):
No enhanced Dosing information available for this drug.
No enhanced Administration information available for this drug.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for AMMONUL (sodium benzoate/sodium phenylacetate):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for AMMONUL (sodium benzoate/sodium phenylacetate):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 1 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Severe renal impairment |
There are 3 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Chronic heart failure |
| Edema |
| Metabolic acidosis |
There are 5 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Disease of liver |
| Hyperglycemia |
| Hypokalemia |
| Kidney disease with reduction in glomerular filtration rate (GFr) |
| Seizure disorder |
The following adverse reaction information is available for AMMONUL (sodium benzoate/sodium phenylacetate):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 18 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Hypokalemia Seizure disorder |
Anemia Disseminated intravascular coagulation Metabolic acidosis |
| Rare/Very Rare |
|---|
|
Bradycardia Cardiomyopathy Cholestasis Drug-induced hepatitis Drug-induced psychosis Extravasation injury Hemorrhage Hypertension Hypotension Pancytopenia Pericardial effusion Renal failure Thrombocytopenic disorder |
There are 18 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Altered mental status Hyperglycemia Infection Vomiting |
Diarrhea Fever Injection site sequelae Nausea |
| Rare/Very Rare |
|---|
|
Alopecia Ataxia Blistering skin Chest pain Flushing Pruritus of skin Skin rash Thrombophlebitis Urinary retention Urticaria |
The following precautions are available for AMMONUL (sodium benzoate/sodium phenylacetate):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for AMMONUL (sodium benzoate/sodium phenylacetate):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for AMMONUL (sodium benzoate/sodium phenylacetate)'s list of indications:
| Arginase deficiency | |
| E72.21 | Argininemia |
| Argininosuccinate lyase deficiency | |
| E72.22 | Arginosuccinic aciduria |
| Carbamoyl phosphate synthetase deficiency | |
| E72.29 | Other disorders of urea cycle metabolism |
| Citrullinemia | |
| E72.23 | Citrullinemia |
| Hyperammonemia | |
| B15.0 | Hepatitis A with hepatic coma |
| B16.0 | Acute hepatitis B with delta-agent with hepatic coma |
| B16.2 | Acute hepatitis B without delta-agent with hepatic coma |
| B17.11 | Acute hepatitis C with hepatic coma |
| B19.0 | Unspecified viral hepatitis with hepatic coma |
| B19.11 | Unspecified viral hepatitis B with hepatic coma |
| B19.21 | Unspecified viral hepatitis C with hepatic coma |
| D81.810 | Biotinidase deficiency |
| E71.110 | Isovaleric acidemia |
| E71.121 | Propionic acidemia |
| E72.20 | Disorder of urea cycle metabolism, unspecified |
| E72.21 | Argininemia |
| E72.22 | Arginosuccinic aciduria |
| E72.23 | Citrullinemia |
| E72.29 | Other disorders of urea cycle metabolism |
| E72.4 | Disorders of ornithine metabolism |
| K72.91 | Hepatic failure, unspecified with coma |
| P74.6 | Transitory hyperammonemia of newborn |
| Isovaleric acidemia | |
| E71.110 | Isovaleric acidemia |
| Ornithine carbamoyltransferase deficiency | |
| E72.4 | Disorders of ornithine metabolism |
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