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UNITUXIN (DINUTUXIMAB)
- High-risk neuroblastoma
3.5 mg/mL intravenous solution
- Dosage information is not available
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
- Myelitis
- Posterior reversible encephalopathy syndrome
- Urinary retention
Contraindicated
- Anemia
- Capillary leak syndrome
- Hemolytic uremic syndrome
- Hypotension
- Neutropenic disorder
- Peripheral neuropathy
- Pregnancy
- Severe infection
- SIADH syndrome
- Thrombocytopenic disorder
Severe
Moderate
- None
UNITUXIN (DINUTUXIMAB)
- High-risk neuroblastoma
- Abnormal hepatic function tests
- Anemia
- Capillary leak syndrome
- Hypersensitivity drug reaction
- Hypokalemia
- Hyponatremia
- Hypotension
- Hypoxia
- Neutropenic disorder
- Thrombocytopenic disorder
- Diarrhea
- Fever
- Hypoalbuminemia
- Hypocalcemia
- Lymphopenia
- Pain
- Urticaria
- Vomiting
More Frequent
Severe
Less Severe
- Bacterial sepsis
- Hemorrhage
- Hypertension
- Infection
- Neuropathic pain
- Peripheral motor neuropathy
- Peripheral sensory neuropathy
- Anorexia
- Hypomagnesemia
- Hypophosphatemia
- Nausea
- Tachycardia
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Blurred vision
- Hemolytic uremic syndrome
- Myelitis
- Optic neuropathy
- Posterior reversible encephalopathy syndrome
Less Severe
- Blepharoptosis
- Mydriasis
- Papilledema
- Photophobia
- Urinary retention
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Dinutuximab
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Dinutuximab
Potential for serious adverse outcomes
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adverse outcomes |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Dinutuximab may cause certain serious side effects, including infusion reactions or nerve problems. You will be given this medication in a hospital or clinic so your doctor can monitor you for side effects and provide treatment if needed. Also, you will be prescribed medications (such as acetaminophen, antihistamines including diphenhydramine) before each dose to decrease the risk of serious side effects.<br /><br />Since most people have nerve pain (such as in the abdomen, arms, legs, back, joints) when receiving this medication, narcotic pain reliever is usually given before, during, and after each dose. If you have side effects, your doctor may temporarily stop or slow down your treatment with this medication. Your doctor may also adjust other medications to help lessen side effects. Tell your doctor right away if you develop symptoms such as fever, chills, severe dizziness, swelling of the face/tongue/throat, trouble breathing, itching, rash, numbness, burning, tingling, weakness, or if you have pain that is not relieved.
| High-risk neuroblastoma | |
| C74.1 | Malignant neoplasm of medulla of adrenal gland |
| C74.10 | Malignant neoplasm of medulla of unspecified adrenal gland |
| C74.11 | Malignant neoplasm of medulla of right adrenal gland |
| C74.12 | Malignant neoplasm of medulla of left adrenal gland |
| 0-9 | A-Z |
|---|---|
| C74.1 | Malignant neoplasm of medulla of adrenal gland |
| C74.10 | Malignant neoplasm of medulla of unspecified adrenal gland |
| C74.11 | Malignant neoplasm of medulla of right adrenal gland |
| C74.12 | Malignant neoplasm of medulla of left adrenal gland |
Formulary Reference Tool