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RIZATRIPTAN (rizatriptan benzoate)
- Migraine
- Rizatriptan Tablet
- Rizatriptan Disintegrating Tablet
- Maxalt-mlt Disintegrating Tablet
- Maxalt Tablet
- By Indication
10 mg tablet
- 1 tablet (10 mg) by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
5 mg tablet
- 1 tablet (5 mg) by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
10 mg disintegrating tablet
- Place 1 tablet (10 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
5 mg disintegrating tablet
- Place 1 tablet (5 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
10 mg disintegrating tablet
- Place 1 tablet (10 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
Maxalt-MLT 10 mg disintegrating tablet
- Place 1 tablet (10 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
10 mg tablet
- 1 tablet (10 mg) by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
Migraine
- Place 1 tablet (5 mg) on top of the tongue where it will dissolve, then swallow by translingual route once, may repeat at 2 hour intervals;Do not exceed 30 mg in 24 hours
- Place 1 tablet (5 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
- 1 tablet (5 mg) by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
- 1 tablet (5 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
- 1 tablet (10 mg) and place on top of the tongue where it will dissolve, then swallow by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
- Place 1 tablet (10 mg) on top of the tongue where it will dissolve, then swallow by translingual route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
- 1 tablet (10 mg) by oral route once, may repeat at 2 hour intervals; do not exceed 30 mg in 24 hours
- Place 1 tablet (10 mg) on top of tongue, allow to dissolve then swallow by translingual route once, may repeat every 2 hrs; max 30 mg/24Hrs
- Azilect
- bromocriptine
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- methylergonovine
- Migergot
- Migranal
- Nardil
- Parlodel
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Conzip
- Nucynta
- Nucynta Er
- Synapryn
- tapentadol
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
Severe
Moderate
- Brintellix
- Brisdelle
- Celexa
- citalopram
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- duloxetine
- Effexor Xr
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- Inderal La
- Inderal Xl
- Innopran Xl
- Khedezla
- levomilnacipran
- Lexapro
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- Pristiq
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- Sarafem
- Savella
- sertraline
- Symbyax
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- Zoloft
- Acute myocardial infarction
- Angina
- Cerebral ischemia
- Cerebrovascular accident
- Coronary artery disease
- Hemiplegic migraine
- Ischemic bowel disease
- Myocardial ischemia
- Peripheral vascular disease
- Prinzmetal angina
- Serotonin syndrome
- Severe uncontrolled hypertension
Contraindicated
- Cardiac arrhythmia
- Increased cardiovascular event risk
Severe
Moderate
- Disease of liver
- End-stage renal disease
- Hypertension
RIZATRIPTAN (rizatriptan benzoate)
- Migraine
- Dyspnea
- Palpitations
- Dizziness
- Drowsy
- Fatigue
- General weakness
- Vomiting
More Frequent
Severe
Less Severe
- Bradycardia
- Cardiac arrhythmia
- Chest pain
- Chest tightness
- Paresthesia
- Tachycardia
- Acute confusion
- Arthralgias
- Constipation
- Depression
- Diarrhea
- Dry eye
- Dyspepsia
- Dysphagia
- Euphoria
- Flatulence
- Flushing
- Hyperhidrosis
- Hypertension
- Hypesthesia
- Irritability
- Muscle rigidity
- Muscle spasm
- Myalgias
- Nausea
- Neck stiffness
- Ocular irritation
- Pain
- Pruritus of skin
- Sensation of cold
- Sensation of warmth
- Tremor
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Angina
- Angioedema
- Cerebrovascular accident
- Hearing loss
- Hypersensitivity drug reaction
- Intracerebral hemorrhage
- Serotonin syndrome
- Subarachnoid intracranial hemorrhage
- Tongue swelling
- Toxic epidermal necrolysis
- Ventricular arrhythmias
- Wheezing
Less Severe
- Acute abdominal pain
- Agitation
- Ataxia
- Blurred vision
- Chills
- Disturbance of attention
- Drug-induced hot flash
- Dysgeusia
- Edema
- Erythema
- Facial edema
- Gait abnormality
- Hallucinations
- Medication overuse headache
- Memory impairment
- Periorbital edema
- Polydipsia
- Polyuria
- Skin rash
- Symptoms of anxiety
- Syncope
- Tinnitus
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
Rizatriptan
Safety and efficacy not established.
- 1 Day – 6 Years
- Safety and efficacy not established.
Management or Monitoring Precaution
None
Rizatriptan
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Rizatriptan
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Rizatriptan
Hepatic-Elderly patients are more likely to have decreased hepatic function thus potentially decreasing drug clearance. Cardiovascular-Hypertensive effects may be more pronounced in the elderly and increase the risk for cardiovascular events in those with cardiovascular disease. Avoid use of the drug in patient with a cerebrovascular syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Migraine | |
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
| 0-9 | A-Z |
|---|---|
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
Formulary Reference Tool