BISOPROLOL-HYDROCHLOROTHIAZIDE (BISOPROLOL FUMARATE/HYDROCHLOROTHIAZIDE)

Moderate

• acarbose

• Adalat Cc

• Advil

• Advil Allergy Sinus

• Advil Allergy-congestion Rlf

• Advil Cold & Sinus

• Advil Congestion Relief

• Advil Liqui-gel

• Advil Migraine

• Advil Pm

• Advil Pm Liqui-gels

• Afeditab Cr

• Aleve

• Aleve Cold & Sinus

• Aleve Sinus & Headache

• Aleve-d Sinus & Cold

• Aleve-d Sinus & Headache

• All Day Pain Relief

• All Day Pain Relief Sinus & Co

• All Day Relief

• Amaryl

• Anaprox

• Anaprox Ds

• Ansaid

• Apidra

• Apidra Solostar

• Calan

• Calan Sr

• Caldolor

• Cardizem

• Cardizem Cd

• Cardizem La

• Cartia Xt

• Child Ibuprofen

• Children's Advil

• Children's Ibu-drops

• Children's Ibuprofen

• Children's Medi-profen

• Children's Motrin

• Children's Profen Ib

• chlorphen-phenyleph-ibuprofen

• chlorphen-pseudoeph-ibuprofen

• cholestyramine (with sugar)

• Cholestyramine Light

• cholestyramine-aspartame

• Cold & Sinus Pain Relief

• Cold-sinus Relief

• Colestid

• Colestid Flavored

• colestipol

• Diabeta

• diazoxide

• Digox

• digoxin

• Dilacor Xr

• Dilt-xr

• diltiazem HCl

• Duetact

• Duexis

• Ec-naprosyn

• Feldene

• Flanax

• flurbiprofen

• glimepiride

• glipizide

• glipizide-metformin

• Glucotrol

• Glucotrol Xl

• Glucovance

• glyburide

• glyburide micronized

• glyburide-metformin

• Glynase

• Glyset

• Humalog

• Humalog Kwikpen

• Humalog Mix 50-50

• Humalog Mix 50-50 Kwikpen

• Humalog Mix 75-25

• Humalog Mix 75-25 Kwikpen

• Humulin 70/30

• Humulin N

• Humulin N Kwikpen

• Humulin R

• Humulin R U-500 "Concentrated"

• hydrocodone-ibuprofen

• I-prin

• Ibu-drops

• Ibudone

• ibuprofen

• Ibuprofen Cold

• Ibuprofen Cold-sinus(with Pse)

• Ibuprofen Ib

• Ibuprofen Jr Strength

• ibuprofen lysine (PF)

• Ibuprofen Pm

• ibuprofen-diphenhydramine

• ibuprofen-diphenhydramine HCl

• ibuprofen-famotidine

• ibuprofen-oxycodone

• ibuprofen-phenylephrine HCl

• Indocin

• indomethacin

• indomethacin sodium

• Infant's Ibuprofen

• Infant's Medi-profen

• Infant's Motrin

• Infants Ibu-drops

• Infants Profenib

• insulin asp prt-insulin aspart

• insulin aspart

• insulin detemir

• insulin glargine

• insulin glulisine

• insulin lispro

• insulin lispro protam-lispro

• insulin NPH and regular human

• insulin regular hum U-500 conc

• insulin regular human

• Lanoxin

• Lanoxin Pediatric

• Lantus

• Lantus Solostar

• Levemir

• Levemir Flexpen

• Matzim La

• Medi-profen

• Mediproxen

• meloxicam

• Midol (naproxen)

• miglitol

• Mobic

• Motrin Ib

• Motrin Pm

• Naprelan Cr

• Naprosyn

• naproxen

• naproxen sodium

• naproxen-esomeprazole

• naproxen-pseudoephedrine

• nateglinide

• Neoprofen (ibuprofen Lysn)(pf)

• Nifedical Xl

• nifedipine

• Novolin 70/30

• Novolin N

• Novolin R

• Novolog

• Novolog Flexpen

• Novolog Mix 70-30

• Novolog Mix 70-30 Flexpen

• Novolog Penfill

• NPH insulin human recomb

• pioglitazone-glimepiride

• piroxicam

• Precose

• Prevalite

• Procardia

• Procardia Xl

• Proglycem

• Provil

• pseudoephedrine-ibuprofen

• Questran

• Questran Light

• Reprexain

• Sinus & Cold-d

• Starlix

• sulindac

• Tarka

• Taztia Xt

• Tiazac

• tolazamide

• tolbutamide

• trandolapril-verapamil

• verapamil

• Verelan

• Verelan Pm

• Vicoprofen

• Vimovo

• Wal-profen

• Wal-profen Cold-sinus

• Wal-proxen

Moderate

• Asthma

• Basal cell carcinoma of skin

• Depression

• Diabetes mellitus

• Disease of liver

• Hypercalcemia

• Hypercholesterolemia

• Hyperparathyroidism

• Myasthenia gravis

• Peripheral vascular disease

• Psoriasis

• Raynaud's phenomenon

• Squamous cell carcinoma of skin

• Sympathectomy

• Systemic lupus erythematosus

Bisoprolol

• Severity Level:

  1

• Additional Notes: Fda c, reports of intrauterine growth retard;monitor fetus/infant for b-blockade

Hydrochlorothiazide

• Severity Level:

  B

• Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Bisoprolol

Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension

Limited amounts excreted with no known adverse effects in infant.

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension

Hydrochlorothiazide

Excret in animal studies;Monitor for signs of b-block:Bradycardia,hypotension

Limited amounts excreted with no known adverse effects in infant.

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Limited amounts excreted with no known adverse effects in infant.

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Bisoprolol

Cardiovascular-Minimize dose to decrease dizziness and falls. Renal-Renal elimination; use caution in starting dose and dose escalation.

Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	N	N	N

BEERS: N     HEDIS: N     STOPP: Y

Hydrochlorothiazide

Cardiovascular-Minimize dose to decrease dizziness and falls. Renal-Renal elimination; use caution in starting dose and dose escalation.

Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	N	Y	N	N	Y

BEERS: Y     HEDIS: N     STOPP: Y

No Known Risk

None

0-9	A-Z
I10	Essential (primary) hypertension
I11	Hypertensive heart disease
I11.0	Hypertensive heart disease with heart failure
I11.9	Hypertensive heart disease without heart failure
I12	Hypertensive chronic kidney disease
I12.0	Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13	Hypertensive heart and chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.1	Hypertensive heart and chronic kidney disease without heart failure
I13.10	Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
I13.2	Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease
I15.1	Hypertension secondary to other renal disorders