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THIOTHIXENE (THIOTHIXENE)
- Schizophrenia
1 mg capsule
- 2 capsules (2 mg) by oral route 3 times per day
10 mg capsule
- 1 capsule (10 mg) by oral route 2 times per day
2 mg capsule
- 1 capsule (2 mg) by oral route 3 times per day
5 mg capsule
- 1 capsule (5 mg) by oral route 2 times per day
1 mg capsule
- 2 capsules (2 mg) by oral route 3 times per day
10 mg capsule
- 1 capsule (10 mg) by oral route 2 times per day
2 mg capsule
- 1 capsule (2 mg) by oral route 3 times per day
5 mg capsule
- 1 capsule (5 mg) by oral route 2 times per day
Schizophrenia
- 2 capsules (2 mg) by oral route 3 times per day
- 1 capsule (2 mg) by oral route 3 times per day
- 2 capsules (4 mg) by oral route 3 times per day
- 1 capsule (5 mg) by oral route 2 times per day
- 1 capsule (5 mg) by oral route 3 times per day
- 2 capsules (10 mg) by oral route 3 times per day
- 1 capsule (10 mg) by oral route 3 times per day
- 1 capsule (10 mg) by oral route 2 times per day
- 1 capsule (10 mg) by oral route once daily
- 2 capsules (10 mg) by oral route once daily
- 2 capsules (10 mg) by oral route 2 times per day
- 2 capsules (20 mg) by oral route once daily
- 2 capsules (20 mg) by oral route 2 times per day
- 2 capsules (20 mg) by oral route 3 times per day
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- Apokyn
- apomorphine
- cabergoline
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- lithium carbonate
- lithium citrate
- Lithobid
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
Severe
Moderate
- Aplenzin
- Buproban
- bupropion HBr
- bupropion HCl
- Forfivo Xl
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zyban
- Agranulocytosis
- Blood dyscrasias
- Coma
- Drug-induced CNS depression
- Lactating mother
- Neuroleptic malignant syndrome
- Shock
- Stupor
Contraindicated
- Alcohol withdrawal syndrome
- Carcinoma of breast
- Cardiac arrhythmia
- Chronic heart failure
- Pregnancy
- Seizure disorder
- Senile dementia
- Tardive dyskinesia
Severe
Moderate
- Angle-closure glaucoma
- Benign prostatic hyperplasia with lower urinary tract sx
- Leukopenia
- Neutropenic disorder
- Parkinsonism
- Urinary retention
THIOTHIXENE (THIOTHIXENE)
- Schizophrenia
- Akathisia
- Extrapyramidal disease
- Parkinsonism
- Tardive dyskinesia
- Constipation
- Decreased sweating
- Drowsy
- Increased appetite
- Nasal congestion
- Orthostatic hypotension
- Skin photosensitivity
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Allergic dermatitis
- Blurred vision
- Corneal deposits
- Dyschromia
- Dysuria
- Hypotension
- Retinal disorder
- Skin rash
- Abnormal sexual function
- Breast engorgement
- Galactorrhea not associated with childbirth
- Hyperglycemia
- Irregular menstrual periods
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Blood dyscrasias
- Granulocytopenic disorder
- Heat stroke
- Leukopenia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Priapism
- Prolonged QT interval
- Seizure disorder
- Venous thrombosis
Less Severe
- Acquired dystonia
- Hyperprolactinemia
Contraindicated
None
Severe Precaution
Thiothixene
Not recommended. High risk of extrapyramidal reactions in children.
- 1 Day – 12 Years
- Not recommended. High risk of extrapyramidal reactions in children.
Management or Monitoring Precaution
None
Thiothixene
- Severity Level:
D
- Additional Notes: No fda category; neonate complications(resp,gi,cns) w/exposure in 3rd trimester
Contraindicated
Thiothixene
Molecular wt low enough for excretion;Possible tardive dyskinesia,drowsiness.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Molecular wt low enough for excretion;Possible tardive dyskinesia,drowsiness. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Thiothixene
Neuro/Psych-Higher risk of tardive dyskinesia in the elderly. Increased risk of death in senile dementia. Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
Formulary Reference Tool