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HYDROCODONE-HOMATROPINE MBR (hydrocodone bitartrate/homatropine methylbromide)
- Cough
- Hydromet Syrup
- Hydromet Oral Syrup
- Hydrocodone-homatropine Tablet
- Hydrocodone-homatropine Syrup
- Hydrocodone-homatropine Oral Syrup
- By Indication
5 mg-1.5 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
5 mg-1.5 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
hydrocodone-homatropine 5 mg-1.5 mg tablet
- 1 tablet by oral route every 6 hours as needed
5 mg-1.5 mg/5 mL (5 mL) oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
5 mg-1.5 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
hydrocodone-homatropine 5 mg-1.5 mg/5 mL (5 mL) oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
hydrocodone-homatropine 5 mg-1.5 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
hydrocodone-homatropine 5 mg-1.5 mg/5 mL (5 mL) oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
hydrocodone-homatropine 5 mg-1.5 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed
Cough
- 5 milliliters by oral route every 4 hours as needed
- 5 milliliters by oral route every 6 hours as needed
- 1 tablet by oral route every 4 hours as needed
- 1 tablet by oral route every 6 hours as needed
- 1 tablet by oral route every 4-6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed
- Depade
- naltrexone
- naltrexone microspheres
- pramlintide
- Revia
- Symlinpen 120
- Symlinpen 60
- Vivitrol
Contraindicated
- amoxicil-clarithromy-lansopraz
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- clarithromycin
- conivaptan in 5 % dextrose
- Crixivan
- Diflucan
- elvitegr-cobicist-emtric-tenof
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- Incivek
- indinavir
- Invirase
- itraconazole
- K-tab
- Kaletra
- Ketek
- ketoconazole
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- lopinavir-ritonavir
- Medi-lyte
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- posaconazole
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- Prevpac
- ritonavir
- saquinavir mesylate
- sodium Cl-potassium chloride
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- Thermotabs
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- voriconazole
- Xyrem
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Adasuve
- aprepitant
- atazanavir
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- butorphanol tartrate
- Butrans
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- chlorpromazine
- cimetidine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- Compazine
- Compro
- darunavir
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Emend
- Fanatrex
- fluphenazine decanoate
- fluphenazine HCl
- fosamprenavir
- fosaprepitant
- gabapentin
- gabapentin enacarbil
- Gleevec
- Gralise
- Gralise 30-day Starter Pack
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Heartburn Relief
- Horizant
- imatinib
- isoniazid-rifamp-pyrazinamide
- Lexiva
- loxapine
- loxapine succinate
- Loxitane
- Matzim La
- Multaq
- nalbuphine
- Neurontin
- perphenazine
- perphenazine-amitriptyline
- Phenadoz
- Phenergan
- Prezista
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- Reyataz
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Suboxone
- Tagamet Hb
- Tarka
- Taztia Xt
- thioridazine
- Tiazac
- trandolapril-verapamil
- trifluoperazine
- verapamil
- Verelan
- Verelan Pm
- Zubsolv
- Achalasia of esophagus
- Angle-closure glaucoma
- Atony of colon
- Hemorrhagic shock
- Myasthenia gravis
- Paralytic ileus
- Pyloroduodenal obstruction
- Severe ulcerative colitis
- Sleep apnea
- Toxic megacolon
Contraindicated
- Acutely deteriorating asthma
- Alcohol intoxication
- Alcohol withdrawal delirium
- Autonomic dysreflexia
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Bradycardia
- Cardiac arrhythmia
- Coma
- Cor pulmonale
- Debilitation
- Dehydration
- Drug abuse
- Gastric ulcer
- Gastrointestinal obstruction
- Gastrointestinal tract surgery
- Hiatal hernia
- History of opioid overdose
- Hypotension
- Inflammatory bowel disease
- Intracranial hypertension
- Morbid obesity
- Neoplasm of brain
- Primary adrenocortical insufficiency
- Pulmonary emphysema
- Reflux esophagitis
- Respiratory depression
- Seizure disorder
- Shock
- Suicidal ideation
- Systemic mastocytosis
- Tachyarrhythmia
- Toxic psychosis
- Toxin-mediated diarrhea
- Ulcerative colitis
- Urethral stricture
- Urinary retention
- Urinary tract obstructive uropathy
Severe
Moderate
- Acute abdominal pain
- Biliary spasm
- Chronic heart failure
- Chronic pulmonary disease
- Constipation
- Coronary artery disease
- Disease of liver
- Down's syndrome
- Drowsy
- Drug dependence
- Gallbladder disease
- Hypertension
- Hyperthyroidism
- Kidney disease with reduction in GFR
- Mood changes
- Salivary secretion disorder
- Untreated hypothyroidism
HYDROCODONE-HOMATROPINE MBR (hydrocodone bitartrate/homatropine methylbromide)
- Cough
- None
- Constipation
- Decreased sweating
- Dizziness
- Drowsy
- General weakness
- Hypotension
- Malaise
- Nausea
- Sedation
- Syncope
More Frequent
Severe
Less Severe
- Angioedema
- Atelectasis
- Bradycardia
- Bronchospastic pulmonary disease
- CNS depression
- Dyspnea
- Laryngeal edema
- Laryngismus
- Pulse changes
- Respiratory depression
- Tachycardia
- Acute abdominal pain
- Acute confusion
- Anorexia
- Arthralgias
- Back pain
- Blurred vision
- Breast milk flow decreased
- Diplopia
- Dysphoric mood
- False sense of well-being
- Fatigue
- Flushing
- Gastroesophageal reflux disease
- Headache disorder
- Hyperhidrosis
- Lethargy
- Mood changes
- Muscle spasm
- Myalgias
- Nervousness
- Night sweats
- Opioid dependence
- Orthostatic hypotension
- Peripheral edema
- Symptoms of anxiety
- Tremor
- Upper respiratory infection
- Ureteral spasm
- Urinary tract infection
- Visual changes
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Acute confusion
- Adrenal cortical insufficiency
- Allergic dermatitis
- Anaphylaxis
- Biliary spasm
- Dehydration
- Depression
- Disorder of adrenal gland
- Female hypogonadism
- Fever
- Hallucinations
- Hearing loss
- Hypertension
- Hypokalemia
- Ileus
- Increased cerebrospinal fluid pressure
- Involuntary muscle movement
- Ischemic colitis
- Male hypogonadism
- Muscle rigidity
- Ocular hypertension
- Pancreatitis
- Paralytic ileus
- Seizure disorder
- Skin rash
- Tinnitus
- Urticaria
Less Severe
- Androgen deficiency
- Ataxia
- Blurred vision
- Drowsy
- Dysgeusia
- Dysphagia
- Dysuria
- Elevated serum amylase
- Erectile dysfunction
- Flatulence
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Infertility
- Insomnia
- Libido changes
- Memory impairment
- Migraine
- Musculoskeletal pain
- Mydriasis
- Nausea
- Neck pain
- Nightmares
- Paresthesia
- Pruritus of skin
- Vomiting
Contraindicated
Homatropine
Possible risk of amblyopia associated with cycloplegia. Not to be used in first 3 months of life.
Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 1 Day – 89 Days
- 1 Possible risk of amblyopia associated with cycloplegia. Not to be used in first 3 months of life.
- 1 Day – 6 Years
- 1 Possible risk of amblyopia associated with cycloplegia. Not to be used in first 3 months of life.
Hydrocodone (Cough-Cold)
Possible risk of amblyopia associated with cycloplegia. Not to be used in first 3 months of life.
Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 1 Day – 89 Days
- 1 Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
- 1 Day – 6 Years
- 1 Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
Severe Precaution
Hydrocodone (cough-cold)
Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
- 6 Years – 18 Years
- Risk of respiratory depression, slowed or difficult breathing, and exposure to the risk of addiction with misuse and abuse. Not indicated in pediatrics.
Management or Monitoring Precaution
Homatropine
Safety and effectiveness in children have not been established.
- 90 Days – 13 Years
- Safety and effectiveness in children have not been established.
Hydrocodone
- Severity Level:
C
- Additional Notes: Neonatal withdrawal/resp.depress. w/chronic or high dose; small teratogenic risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Homatropine
May inhibit lactation. avoid chronic use.
Monitor for changes in respiration, gi effects, sedation, feeding patterns
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | May inhibit lactation. avoid chronic use. |
Hydrocodone
May inhibit lactation. avoid chronic use.
Monitor for changes in respiration, gi effects, sedation, feeding patterns
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Monitor for changes in respiration, gi effects, sedation, feeding patterns |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Homatropine
Neuro/Psych-Avoid in older adults with dementia, cognitive impairment and delirium due to anticholinergic activity. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Pulmonary-Respiratory depression is more likely to occur in elderly due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Consider naloxone Rx. Neuro/Psych-Risk for confusion, delirium and falls. Avoid treatment with 3 or more CNS active agents. Gastrointestinal-Constipation risk. Renal-Impaired function may lead to increased toxicity due to accumulation of parent compound and metabolites. Cardiovascular-Monitor for hypotension with high doses.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Hydrocodone
Neuro/Psych-Avoid in older adults with dementia, cognitive impairment and delirium due to anticholinergic activity. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Pulmonary-Respiratory depression is more likely to occur in elderly due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Consider naloxone Rx. Neuro/Psych-Risk for confusion, delirium and falls. Avoid treatment with 3 or more CNS active agents. Gastrointestinal-Constipation risk. Renal-Impaired function may lead to increased toxicity due to accumulation of parent compound and metabolites. Cardiovascular-Monitor for hypotension with high doses.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | Y | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal, breathing problems. To lower your risk, your doctor should have you take the smallest dose that works, and take it for the shortest possible time.<br /><br />See also How to Use section for more information about addiction. The risk for severe breathing problems is higher when you start this medication, or if you take the wrong dose or take more of this medication than prescribed. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death.<br /><br /> Also, other medications can affect the removal of this product from your body, which may affect how it works. Be sure you know how to take this product and what other drugs you should avoid taking with it. See also Drug Interactions section.<br /><br />Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get medical help right away.<br /><br /> Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or think you may be pregnant. During pregnancy, this medication is not recommended.<br /><br />It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time.<br /><br />Babies born to mothers who use this drug for a long time may develop severe (possibly fatal) withdrawal symptoms. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.
| Cough | |
| R05 | Cough |
| 0-9 | A-Z |
|---|---|
| R05 | Cough |
Formulary Reference Tool