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RIBASPHERE (ribavirin)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 3
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 2
200 mg capsule
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
600 mg tablet
- 1 tablet (600 mg) by oral route 2 times per day with food
200 mg capsule
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
Chronic hepatitis C - genotype 1
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
Chronic hepatitis C - genotype 2
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
Chronic hepatitis C - genotype 3
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
Chronic hepatitis C - genotype 4
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
Chronic hepatitis C - genotype 5
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
Chronic hepatitis C - genotype 6
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 24 weeks
- 2 capsules (400 mg) by oral route 2 times per day for patients weighing less than or equal to 65 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing 66 kg to 80 kg for 48 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening for patients weighing less than or equal to 75Kg for 24 weeks
- 2 capsules (400 mg) by oral route in the morning and 3 capsules (600 mg) in the evening (patients weighing less than or equal to 75 kg)
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing more than 75 kg
- 1 tablet (600 mg) by oral route 2 times per day with food
- 1 tablet (600 mg) by oral route 2 times per day with food for 24Weeks
- 1 tablet (600 mg) by oral route 2 times per day with food for 48Weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route 2 times per day for patients weighing 81 kg to 105 kg for 48 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 24 weeks
- 3 capsules (600 mg) by oral route in the morning and 4 capsules (800 mg) in the evening for patients weighing more than 105 kg for 48 weeks
- didanosine
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
Contraindicated
- abacavir-lamivudine-zidovudine
- clozapine
- Clozaril
- Combivir
- deferiprone
- Fazaclo
- Ferriprox
- lamivudine-zidovudine
- Retrovir
- stavudine
- Trizivir
- Versacloz
- Zerit
- zidovudine
Severe
Moderate
- Azasan
- azathioprine
- azathioprine sodium
- Imuran
- mercaptopurine
- Purinethol
- Autoimmune hepatitis
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Hemolytic anemia
- Pancreatitis
- Pregnancy
- Sickle cell disease
- Thalassemia
Contraindicated
- Acute myocardial infarction
- Bone marrow depression
- Hepatic cirrhosis
- Interstitial pneumonitis
- Myocardial ischemia
- Neutropenic disorder
- Pulmonary infiltrates
- Pure red cell aplasia
- Severe anemia
- Severe coronary artery disease
Severe
Moderate
- Periodontitis
- Sarcoidosis
RIBASPHERE (ribavirin)
- Chronic hepatitis C - genotype 1
- Chronic hepatitis C - genotype 3
- Chronic hepatitis C - genotype 4
- Chronic hepatitis C - genotype 2
- Anemia
- Chest pain
- Dyspnea
- Hemolytic anemia
- Neutropenic disorder
- Acute abdominal pain
- Arthralgias
- Chills
- Depression
- Diarrhea
- Dizziness
- Dry skin
- Dyspepsia
- Fatigue
- Fever
- General weakness
- Headache disorder
- Irritability
- Myalgias
- Nausea
- Pruritus of skin
- Vomiting
- Weight gain
More Frequent
Severe
Less Severe
- Bacterial infection
- Leukopenia
- Pharyngitis
- Alopecia
- Anorexia
- Conjunctivitis
- Dysgeusia
- Insomnia
- Mood changes
- Nervousness
- Rhinitis
- Sinusitis
- Skin rash
- Upper abdominal pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Blurred vision
- Bone marrow depression
- Bronchospastic pulmonary disease
- Bullous dermatitis
- Dehydration
- Diabetes mellitus
- Drug-induced psychosis
- Hallucinations
- Hearing disorder
- Hepatic failure
- Hypothyroidism
- Idiopathic thrombocytopenic purpura
- Interstitial pneumonitis
- Kidney transplant rejection
- Liver transplant rejection
- Pancreatitis
- Pneumonia
- Pulmonary hypertension
- Pulmonary infiltrates
- Pure red cell aplasia
- Retinal detachment
- Sarcoidosis
- Stevens-johnson syndrome
- Suicidal ideation
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Concentration difficulty
- Menstrual disorder
- Periodontal infection
- Tooth disorder
- Vertigo
Contraindicated
None
Severe Precaution
Ribavirin (Oral)
Reports of growth inhibition in combination therapy with interferon. Limited data to determine if ultimate adult height is reduced. Safety and efficacy not established age < 3 years.
Growth delay observed when used in combination with interferon. Data insufficient to determine if adult height is reduced. Possible suicidal ideation in adolescents, observe behavior.
- 1 Day – 3 Years
- Reports of growth inhibition in combination therapy with interferon. Limited data to determine if ultimate adult height is reduced. Safety and efficacy not established age < 3 years.
- Growth delay observed when used in combination with interferon. Data insufficient to determine if adult height is reduced. Possible suicidal ideation in adolescents, observe behavior.
- 3 Years – 18 Years
- Reports of growth inhibition in combination therapy with interferon. Limited data to determine if ultimate adult height is reduced. Safety and efficacy not established age < 3 years.
- Growth delay observed when used in combination with interferon. Data insufficient to determine if adult height is reduced. Possible suicidal ideation in adolescents, observe behavior.
Management or Monitoring Precaution
None
Ribavirin
- Severity Level:
1
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ribavirin
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Ribavirin may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take ribavirin, and contact your doctor right away. Women and men who are taking ribavirin must avoid pregnancy by using two forms of reliable birth control (such as latex condoms and birth control pills) during treatment with this drug and for 6 months after this medication has been stopped.<br /><br />Consult your doctor or pharmacist for more information. Patients with certain types of heart disease should not use ribavirin because it can lower your red blood cell level (anemia). This may worsen your condition and can lead to a possibly fatal heart attack.<br /><br />Before using this medication, tell your doctor if you have had any heart problems or chest pain. Ribavirin should never be used alone to treat hepatitis C infections.
| Chronic hepatitis C - genotype 1 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 2 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 3 | |
| B18.2 | Chronic viral hepatitis C |
| Chronic hepatitis C - genotype 4 | |
| B18.2 | Chronic viral hepatitis C |
| 0-9 | A-Z |
|---|---|
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
| B18.2 | Chronic viral hepatitis C |
Formulary Reference Tool