TOPOTECAN HCL (TOPOTECAN HCL)
- Carcinoma of cervix
- Malignant neoplasm of the ovary
- Small cell lung carcinoma
topotecan 4 mg/4 mL (1 mg/mL) intravenous solution
- Infuse 1.5 mg/m2 over 30 minute(s) by intravenous route once daily for 5 consecutive days starting on day 1 of a 21 day course
Carcinoma of cervix
- Infuse 0.75 mg/m2 over 30 minute(s) by intravenous route on days 1 through 3 of a 21 day treatment cycle
Malignant neoplasm of the ovary
- Infuse 1.5 mg/m2 over 30 minute(s) by intravenous route once daily for 5 consecutive days starting on day 1 of a 21 day course
Small cell lung carcinoma
- Infuse 1.5 mg/m2 over 30 minute(s) by intravenous route once daily for 5 consecutive days starting on day 1 of a 21 day course
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- B3,azel,quer&tur-FA-B6-zn-copp
- Cerebyx
- clozapine
- Clozaril
- deferiprone
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Fazaclo
- Ferriprox
- fosphenytoin
- glucosam-csa-mv-min AA-hrb 162
- mag oxide-D3-turmeric rt xt
- me-thfolate gluc-B12-herb #236
- milk prot-turm-pepper-pinea ex
- Nicazel Forte
- nut.tx, metab.dis, mv & min #4
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Proteolin
- Proteolin Ds
- Rheumate
- Ultra Inflamx Plus 360
- Versacloz
Severe
Moderate
- filgrastim
- Granix
- Leukine
- Neulasta
- Neupogen
- pegfilgrastim
- sargramostim
- tbo-filgrastim
- Interstitial lung disease
- Lactating mother
Contraindicated
- Anemia
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Neutropenic disorder
- Pregnancy
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- Pulmonary fibrosis
- Radiation therapy involving the lungs
TOPOTECAN HCL (TOPOTECAN HCL)
- Carcinoma of cervix
- Malignant neoplasm of the ovary
- Small cell lung carcinoma
- Anemia
- Diarrhea
- Dyspnea
- Fever
- Leukopenia
- Neutropenic disorder
- Pain
- Thrombocytopenic disorder
- Abdominal pain with cramps
- Alopecia
- Anorexia
- Arthralgias
- Constipation
- Cough
- Fatigue
- General weakness
- Headache disorder
- Hyperhidrosis
- Lethargy
- Malaise
- Nausea
- Paresthesia
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Gastrointestinal obstruction
- Hyperbilirubinemia
- Infection
- Pneumonia
- Abnormal hepatic function tests
- Bone pain
- Chest pain
- Chills
- Dysmenorrhea
- Earache
- Neuropathic pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Bacterial sepsis
- Enterocolitis
- Gastrointestinal perforation
- Hemorrhage
- Interstitial lung disease
- Neutropenic colitis
- Pancytopenia
- Pruritus of skin
- Skin rash
Less Severe
- Dyspareunia
- Extravasation injury
- Peripheral sensory neuropathy
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Topotecan
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Topotecan
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Topotecan
Contraindicated per manufacturer; potential for severe adverse effects
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Contraindicated per manufacturer; potential for severe adverse effects |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Topotecan
Renal-Adjust dose for decreased renal function of aging for CrCL <40 mL/min. Gastrointestinal- Treatment-related diarrhea was more frequent in patients aged greater than or equal to 65 years (28%).
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Topotecan decreases bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding.<br /><br /> Your doctor will order blood tests to monitor your bone marrow function while you are using this medication. Keep all medical and lab appointments.
Carcinoma of cervix | |
C53 | Malignant neoplasm of cervix uteri |
C53.0 | Malignant neoplasm of endocervix |
C53.1 | Malignant neoplasm of exocervix |
C53.8 | Malignant neoplasm of overlapping sites of cervix uteri |
C53.9 | Malignant neoplasm of cervix uteri, unspecified |
Malignant neoplasm of the ovary | |
C56 | Malignant neoplasm of ovary |
C56.1 | Malignant neoplasm of right ovary |
C56.2 | Malignant neoplasm of left ovary |
C56.9 | Malignant neoplasm of unspecified ovary |
Small cell lung carcinoma | |
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
0-9 | A-Z |
---|---|
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
C53 | Malignant neoplasm of cervix uteri |
C53.0 | Malignant neoplasm of endocervix |
C53.1 | Malignant neoplasm of exocervix |
C53.8 | Malignant neoplasm of overlapping sites of cervix uteri |
C53.9 | Malignant neoplasm of cervix uteri, unspecified |
C56 | Malignant neoplasm of ovary |
C56.1 | Malignant neoplasm of right ovary |
C56.2 | Malignant neoplasm of left ovary |
C56.9 | Malignant neoplasm of unspecified ovary |