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MEXILETINE HCL (MEXILETINE HCL)
- Ventricular arrhythmias
mexiletine 150 mg capsule
- 2 capsules (300 mg) by oral route every 8 hours with food
mexiletine 200 mg capsule
- 1 capsule (200 mg) by oral route every 8 hours with food
mexiletine 250 mg capsule
- 1 capsule (250 mg) by oral route every 8 hours with food
Ventricular arrhythmias
- 1 capsule (200 mg) by oral route every 8 hours with food
- 1 capsule (250 mg) by oral route every 8 hours with food
- 2 capsules (300 mg) by oral route every 8 hours with food
- 2 capsules (400 mg) by oral route every 8 hours with food
- 3 capsules (450 mg) by oral route every 12 hours with food
- None
Contraindicated
- tizanidine
- Zanaflex
Severe
Moderate
- Azilect
- isoniazid-rifamp-pyrazinamide
- Mycobutin
- Priftin
- rasagiline
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Cardiogenic shock
- Complete atrioventricular block
- Second degree atrioventricular heart block
Contraindicated
- Abnormal hepatic function tests
Severe
Moderate
- Acute myocardial infarction
- Disease of liver
- Hypotension
- Seizure disorder
- Severe chronic heart failure
- Sick sinus syndrome
- Tobacco smoker
MEXILETINE HCL (MEXILETINE HCL)
- Ventricular arrhythmias
- None
- Dizziness
- Dyskinesia
- Heartburn
- Nausea
- Nervousness
- Tremor
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Chest pain
- Dyspnea
- Increased aspartate transaminase
- Ventricular premature beats
- Acute confusion
- Blurred vision
- Constipation
- Diarrhea
- Fatigue
- General weakness
- Headache disorder
- Insomnia
- Paresthesia
- Skin rash
- Slurred speech
- Tinnitus
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Agranulocytosis
- Disease of liver
- DRESS syndrome
- Hepatic necrosis
- Leukopenia
- Neutropenic disorder
- Pulmonary fibrosis
- Pulmonary infiltrates
- Seizure disorder
- Thrombocytopenic disorder
- Ventricular arrhythmias
Less Severe
- Abdominal pain with cramps
- Arthralgias
- Fever
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Mexiletine
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Mexilitene Hydrochloride
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Mexiletine
Limited data suggest low levels excreted resulting in no infant adv effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest low levels excreted resulting in no infant adv effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Though this medication often gives great benefits to people with irregular heartbeat, it may rarely cause a serious new irregular heartbeat. Therefore, when starting treatment with this drug, your doctor may recommend that you stay in the hospital for proper monitoring. Talk with your doctor about the benefits and risks of taking this medication for your condition.
| Ventricular arrhythmias | |
| I49.01 | Ventricular fibrillation |
| I49.02 | Ventricular flutter |
| I49.9 | Cardiac arrhythmia, unspecified |
| 0-9 | A-Z |
|---|---|
| I49.01 | Ventricular fibrillation |
| I49.02 | Ventricular flutter |
| I49.9 | Cardiac arrhythmia, unspecified |
Formulary Reference Tool