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MEPERIDINE HCL (MEPERIDINE HCL)
- Acute pain
- Severe pain
100 mg tablet
- 1 tablet (100 mg) by oral route every 4 hours as needed
50 mg tablet
- 1 tablet (50 mg) by oral route every 4 hours as needed
meperidine 100 mg tablet
- 1 tablet (100 mg) by oral route every 4 hours as needed
meperidine 50 mg tablet
- 1 tablet (50 mg) by oral route every 4 hours as needed
meperidine 50 mg/5 mL oral solution
- 5 milliliters (50 mg) by oral route every 4 hours as needed
100 mg tablet
- 1 tablet (100 mg) by oral route every 4 hours as needed
100 mg tablet
- 1 tablet (100 mg) by oral route every 4 hours as needed
Acute pain
- 1 tablet (50 mg) by oral route every 4 hours as needed
- 1 tablet (50 mg) by oral route every 3 hours as needed
- 5 milliliters (50 mg) by oral route every 3 hours as needed
- 5 milliliters (50 mg) by oral route every 4 hours as needed
- 2 tablets (100 mg) by oral route every 3 hours as needed
- 10 milliliters (100 mg) by oral route every 3 hours as needed
- 10 milliliters (100 mg) by oral route every 4 hours as needed
- 2 tablets (100 mg) by oral route every 4 hours as needed
- 1 tablet (100 mg) by oral route every 4 hours as needed
- 1 tablet (100 mg) by oral route every 3 hours as needed
- 3 tablets (150 mg) by oral route every 3 hours as needed
- 3 tablets (150 mg) by oral route every 4 hours as needed
- 15 milliliters (150 mg) by oral route every 3 hours as needed
- 15 milliliters (150 mg) by oral route every 4 hours as needed
Severe pain
- 1 tablet (50 mg) by oral route every 4 hours as needed
- 1 tablet (50 mg) by oral route every 3 hours as needed
- 5 milliliters (50 mg) by oral route every 3 hours as needed
- 5 milliliters (50 mg) by oral route every 4 hours as needed
- 2 tablets (100 mg) by oral route every 3 hours as needed
- 10 milliliters (100 mg) by oral route every 3 hours as needed
- 10 milliliters (100 mg) by oral route every 4 hours as needed
- 2 tablets (100 mg) by oral route every 4 hours as needed
- 1 tablet (100 mg) by oral route every 4 hours as needed
- 1 tablet (100 mg) by oral route every 3 hours as needed
- 3 tablets (150 mg) by oral route every 3 hours as needed
- 3 tablets (150 mg) by oral route every 4 hours as needed
- 15 milliliters (150 mg) by oral route every 3 hours as needed
- 15 milliliters (150 mg) by oral route every 4 hours as needed
- Azilect
- Depade
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- naltrexone
- naltrexone microspheres
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- Revia
- selegiline HCl
- tranylcypromine
- Vivitrol
- Zelapar
- Zyvox
Contraindicated
- amoxicil-clarithromy-lansopraz
- Anafranil
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Brintellix
- Brisdelle
- Celexa
- citalopram
- clarithromycin
- clomipramine
- conivaptan in 5 % dextrose
- Crixivan
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- Diflucan
- duloxetine
- Effexor Xr
- elvitegr-cobicist-emtric-tenof
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- escitalopram oxalate
- Fetzima
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluoxetine
- fluvoxamine
- Incivek
- indinavir
- Invirase
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Khedezla
- levomilnacipran
- Lexapro
- lopinavir-ritonavir
- Luvox Cr
- milnacipran
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- olanzapine-fluoxetine
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- posaconazole
- Prevpac
- Pristiq
- Prozac
- Prozac Weekly
- ritonavir
- saquinavir mesylate
- Sarafem
- Savella
- sertraline
- sodium oxybate
- Sporanox
- Sporanox Pulsepak
- Stribild
- Symbyax
- telaprevir
- telithromycin
- Vaprisol
- venlafaxine
- Vfend
- Vfend Iv
- Victrelis
- Viibryd
- vilazodone
- Viracept
- voriconazole
- vortioxetine
- Xyrem
- Zoloft
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- aprepitant
- atazanavir
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- butorphanol tartrate
- Butrans
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- cimetidine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- darunavir
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dronedarone
- Emend
- Fanatrex
- fosamprenavir
- fosaprepitant
- gabapentin
- gabapentin enacarbil
- Gleevec
- Gralise
- Gralise 30-day Starter Pack
- Heartburn Relief
- Horizant
- imatinib
- isoniazid-rifamp-pyrazinamide
- Lexiva
- Matzim La
- Multaq
- nalbuphine
- Neurontin
- Oleptro Er
- Prezista
- Reyataz
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Suboxone
- Tagamet Hb
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- trazodone
- verapamil
- Verelan
- Verelan Pm
- Zubsolv
- Gastrointestinal obstruction
- Serotonin syndrome
Contraindicated
- Acute asthma attack
- Acute respiratory insufficiency
- Adrenal cortical insufficiency
- Alcohol intoxication
- Chronic obstructive pulmonary disease
- Cor pulmonale
- Drug abuse
- Drug dependence
- History of opioid overdose
- Kidney disease with likely reduction in GFR
- Primary adrenocortical insufficiency
- Respiratory depression
Severe
Moderate
- Atrial flutter
- Benign prostatic hyperplasia
- Hypotension
- Hypothyroidism
- Intracranial hypertension
- Myxedema
- Pheochromocytoma
- Seizure disorder
- Severe hepatic disease
- Sickle cell disease
- Supraventricular tachycardia
- Toxic psychosis
- Urethral stricture
MEPERIDINE HCL (MEPERIDINE HCL)
- Acute pain
- Severe pain
- Flushing
- Hypotension
- Constipation
- Dizziness
- Drowsy
- General weakness
- Nausea
- Sedation
- Syncope
- Vomiting
More Frequent
Severe
Less Severe
- Acute confusion
- Atelectasis
- Bradycardia
- Bronchospastic pulmonary disease
- Dyspnea
- Involuntary muscle movement
- Laryngeal edema
- Laryngismus
- Orthostatic hypotension
- Respiratory depression
- Seizure disorder
- Tachycardia
- Agitation
- Biliary spasm
- Blurred vision
- Diplopia
- Dysphoric mood
- False sense of well-being
- Gastrointestinal irritation
- Headache disorder
- Hyperhidrosis
- Nightmares
- Palpitations
- Ureteral spasm
- Urinary retention
- Visual changes
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Adrenal cortical insufficiency
- Allergic dermatitis
- Anaphylaxis
- Androgen deficiency
- Cardiac arrest
- Circulatory depression
- Hallucinations
- Pruritus of skin
- Serotonin syndrome
- Shock
- Skin rash
- Tonic clonic seizure
- Urticaria
Less Severe
- Delirium
- Erectile dysfunction
- Infertility
- Libido changes
- Phlebitis after infusion
- Tremor
- Twitching
Contraindicated
Meperidine
Increased sensitivity to effects, adverse CNS effects and respiratory depression.
- 1 Day – 29 Days
- 1 Increased sensitivity to effects, adverse CNS effects and respiratory depression.
Severe Precaution
Meperidine
Risk of adverse CNS effects and respiratory depression.
- 30 Days – 18 Years
- Risk of adverse CNS effects and respiratory depression.
Management or Monitoring Precaution
None
Meperidine Hydrochloride
- Severity Level:
2
- Additional Notes: Neonatal withdrawal/resp.depress. w/chronic or high dose
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Meperidine Hydrochloride
Monitor for signs of respiratory depression and increased drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Monitor for signs of respiratory depression and increased drowsiness |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Meperidine
Renal-Adjust dose for renal impairment due to renally cleared metabolite. Neuro/Psych-Risk for increased confusion, delirium, falls and seizures with accumulation. Avoid treatment with 3 or more CNS active agents. Consider safer alternatives. General-Consider naloxone prescription to mitigate accidental overdose.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Meperidine has a risk for abuse and addiction, which can lead to overdose and death. Meperidine may also cause severe, possibly fatal, breathing problems. To lower your risk, your doctor should have you take the smallest dose of meperidine that works, and take it for the shortest possible time.<br /><br />See also How to Use section for more information about addiction. The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you take the wrong dose/strength. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death.<br /><br />Also, other medications can affect the removal of meperidine from your body, which may affect how meperidine works. Be sure you know how to take meperidine and what other drugs you should avoid taking with it. See also Drug Interactions section.<br /><br />Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get medical help right away.<br /><br /> Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed.<br /><br />It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time.<br /><br /> Babies born to mothers who use this drug for a long time may develop severe (possibly fatal) withdrawal symptoms. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.
| Acute pain | |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.18 | Other acute postprocedural pain |
| Severe pain | |
| G89 | Pain, not elsewhere classified |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.12 | Acute post-thoracotomy pain |
| G89.18 | Other acute postprocedural pain |
| G89.2 | Chronic pain, not elsewhere classified |
| G89.21 | Chronic pain due to trauma |
| G89.22 | Chronic post-thoracotomy pain |
| G89.28 | Other chronic postprocedural pain |
| G89.29 | Other chronic pain |
| G89.3 | Neoplasm related pain (acute) (chronic) |
| M25.5 | Pain in joint |
| M25.50 | Pain in unspecified joint |
| M25.51 | Pain in shoulder |
| M25.511 | Pain in right shoulder |
| M25.512 | Pain in left shoulder |
| M25.519 | Pain in unspecified shoulder |
| M25.52 | Pain in elbow |
| M25.521 | Pain in right elbow |
| M25.522 | Pain in left elbow |
| M25.529 | Pain in unspecified elbow |
| M25.53 | Pain in wrist |
| M25.531 | Pain in right wrist |
| M25.532 | Pain in left wrist |
| M25.539 | Pain in unspecified wrist |
| M25.54 | Pain in joints of hand |
| M25.541 | Pain in joints of right hand |
| M25.542 | Pain in joints of left hand |
| M25.549 | Pain in joints of unspecified hand |
| M25.55 | Pain in hip |
| M25.551 | Pain in right hip |
| M25.552 | Pain in left hip |
| M25.559 | Pain in unspecified hip |
| M25.56 | Pain in knee |
| M25.561 | Pain in right knee |
| M25.562 | Pain in left knee |
| M25.569 | Pain in unspecified knee |
| M25.57 | Pain in ankle and joints of foot |
| M25.571 | Pain in right ankle and joints of right foot |
| M25.572 | Pain in left ankle and joints of left foot |
| M25.579 | Pain in unspecified ankle and joints of unspecified foot |
| M26.62 | Arthralgia of temporomandibular joint |
| M54.5 | Low back pain |
| M54.6 | Pain in thoracic spine |
| M79.6 | Pain in limb, hand, foot, fingers and toes |
| M79.60 | Pain in limb, unspecified |
| M79.601 | Pain in right arm |
| M79.602 | Pain in left arm |
| M79.603 | Pain in arm, unspecified |
| M79.604 | Pain in right leg |
| M79.605 | Pain in left leg |
| M79.606 | Pain in leg, unspecified |
| M79.609 | Pain in unspecified limb |
| M79.62 | Pain in upper arm |
| M79.621 | Pain in right upper arm |
| M79.622 | Pain in left upper arm |
| M79.629 | Pain in unspecified upper arm |
| M79.63 | Pain in forearm |
| M79.631 | Pain in right forearm |
| M79.632 | Pain in left forearm |
| M79.639 | Pain in unspecified forearm |
| M79.64 | Pain in hand and fingers |
| M79.641 | Pain in right hand |
| M79.642 | Pain in left hand |
| M79.643 | Pain in unspecified hand |
| M79.644 | Pain in right finger(s) |
| M79.645 | Pain in left finger(s) |
| M79.646 | Pain in unspecified finger(s) |
| M79.65 | Pain in thigh |
| M79.651 | Pain in right thigh |
| M79.652 | Pain in left thigh |
| M79.659 | Pain in unspecified thigh |
| M79.66 | Pain in lower leg |
| M79.661 | Pain in right lower leg |
| M79.662 | Pain in left lower leg |
| M79.669 | Pain in unspecified lower leg |
| M79.67 | Pain in foot and toes |
| M79.671 | Pain in right foot |
| M79.672 | Pain in left foot |
| M79.673 | Pain in unspecified foot |
| M79.674 | Pain in right toe(s) |
| M79.675 | Pain in left toe(s) |
| M79.676 | Pain in unspecified toe(s) |
| R07.82 | Intercostal pain |
| R10.0 | Acute abdomen |
| R10.1 | Pain localized to upper abdomen |
| R10.10 | Upper abdominal pain, unspecified |
| R10.11 | Right upper quadrant pain |
| R10.12 | Left upper quadrant pain |
| R10.2 | Pelvic and perineal pain |
| R10.3 | Pain localized to other parts of lower abdomen |
| R10.30 | Lower abdominal pain, unspecified |
| R10.31 | Right lower quadrant pain |
| R10.32 | Left lower quadrant pain |
| R10.33 | Periumbilical pain |
| R10.8 | Other abdominal pain |
| R10.84 | Generalized abdominal pain |
| R10.9 | Unspecified abdominal pain |
| R52 | Pain, unspecified |
| R68.84 | Jaw pain |
| 0-9 | A-Z |
|---|---|
| G89 | Pain, not elsewhere classified |
| G89.1 | Acute pain, not elsewhere classified |
| G89.1 | Acute pain, not elsewhere classified |
| G89.11 | Acute pain due to trauma |
| G89.11 | Acute pain due to trauma |
| G89.12 | Acute post-thoracotomy pain |
| G89.18 | Other acute postprocedural pain |
| G89.18 | Other acute postprocedural pain |
| G89.2 | Chronic pain, not elsewhere classified |
| G89.21 | Chronic pain due to trauma |
| G89.22 | Chronic post-thoracotomy pain |
| G89.28 | Other chronic postprocedural pain |
| G89.29 | Other chronic pain |
| G89.3 | Neoplasm related pain (acute) (chronic) |
| M25.5 | Pain in joint |
| M25.50 | Pain in unspecified joint |
| M25.51 | Pain in shoulder |
| M25.511 | Pain in right shoulder |
| M25.512 | Pain in left shoulder |
| M25.519 | Pain in unspecified shoulder |
| M25.52 | Pain in elbow |
| M25.521 | Pain in right elbow |
| M25.522 | Pain in left elbow |
| M25.529 | Pain in unspecified elbow |
| M25.53 | Pain in wrist |
| M25.531 | Pain in right wrist |
| M25.532 | Pain in left wrist |
| M25.539 | Pain in unspecified wrist |
| M25.54 | Pain in joints of hand |
| M25.541 | Pain in joints of right hand |
| M25.542 | Pain in joints of left hand |
| M25.549 | Pain in joints of unspecified hand |
| M25.55 | Pain in hip |
| M25.551 | Pain in right hip |
| M25.552 | Pain in left hip |
| M25.559 | Pain in unspecified hip |
| M25.56 | Pain in knee |
| M25.561 | Pain in right knee |
| M25.562 | Pain in left knee |
| M25.569 | Pain in unspecified knee |
| M25.57 | Pain in ankle and joints of foot |
| M25.571 | Pain in right ankle and joints of right foot |
| M25.572 | Pain in left ankle and joints of left foot |
| M25.579 | Pain in unspecified ankle and joints of unspecified foot |
| M26.62 | Arthralgia of temporomandibular joint |
| M54.5 | Low back pain |
| M54.6 | Pain in thoracic spine |
| M79.6 | Pain in limb, hand, foot, fingers and toes |
| M79.60 | Pain in limb, unspecified |
| M79.601 | Pain in right arm |
| M79.602 | Pain in left arm |
| M79.603 | Pain in arm, unspecified |
| M79.604 | Pain in right leg |
| M79.605 | Pain in left leg |
| M79.606 | Pain in leg, unspecified |
| M79.609 | Pain in unspecified limb |
| M79.62 | Pain in upper arm |
| M79.621 | Pain in right upper arm |
| M79.622 | Pain in left upper arm |
| M79.629 | Pain in unspecified upper arm |
| M79.63 | Pain in forearm |
| M79.631 | Pain in right forearm |
| M79.632 | Pain in left forearm |
| M79.639 | Pain in unspecified forearm |
| M79.64 | Pain in hand and fingers |
| M79.641 | Pain in right hand |
| M79.642 | Pain in left hand |
| M79.643 | Pain in unspecified hand |
| M79.644 | Pain in right finger(s) |
| M79.645 | Pain in left finger(s) |
| M79.646 | Pain in unspecified finger(s) |
| M79.65 | Pain in thigh |
| M79.651 | Pain in right thigh |
| M79.652 | Pain in left thigh |
| M79.659 | Pain in unspecified thigh |
| M79.66 | Pain in lower leg |
| M79.661 | Pain in right lower leg |
| M79.662 | Pain in left lower leg |
| M79.669 | Pain in unspecified lower leg |
| M79.67 | Pain in foot and toes |
| M79.671 | Pain in right foot |
| M79.672 | Pain in left foot |
| M79.673 | Pain in unspecified foot |
| M79.674 | Pain in right toe(s) |
| M79.675 | Pain in left toe(s) |
| M79.676 | Pain in unspecified toe(s) |
| R07.82 | Intercostal pain |
| R10.0 | Acute abdomen |
| R10.1 | Pain localized to upper abdomen |
| R10.10 | Upper abdominal pain, unspecified |
| R10.11 | Right upper quadrant pain |
| R10.12 | Left upper quadrant pain |
| R10.2 | Pelvic and perineal pain |
| R10.3 | Pain localized to other parts of lower abdomen |
| R10.30 | Lower abdominal pain, unspecified |
| R10.31 | Right lower quadrant pain |
| R10.32 | Left lower quadrant pain |
| R10.33 | Periumbilical pain |
| R10.8 | Other abdominal pain |
| R10.84 | Generalized abdominal pain |
| R10.9 | Unspecified abdominal pain |
| R52 | Pain, unspecified |
| R68.84 | Jaw pain |
Formulary Reference Tool