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Drug overview for FLUVASTATIN SODIUM (fluvastatin sodium):
Generic name: FLUVASTATIN SODIUM (FLEW-vuh-stat-in)
Drug class: Antihyperlipidemics HMGCo-A Reductase Inhibitors (Statins)
Therapeutic class: Cardiovascular Therapy Agents
Fluvastatin sodium, a hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor (i.e., statin), is an antilipemic agent.
No enhanced Uses information available for this drug.
Generic name: FLUVASTATIN SODIUM (FLEW-vuh-stat-in)
Drug class: Antihyperlipidemics HMGCo-A Reductase Inhibitors (Statins)
Therapeutic class: Cardiovascular Therapy Agents
Fluvastatin sodium, a hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor (i.e., statin), is an antilipemic agent.
No enhanced Uses information available for this drug.
DRUG IMAGES
FLUVASTATIN SODIUM 40 MG CAP
FLUVASTATIN SODIUM 20 MG CAP
The following indications for FLUVASTATIN SODIUM (fluvastatin sodium) have been approved by the FDA:
Indications:
Atherosclerotic cardiovascular disease
Heterozygous familial hypercholesterolemia
Hypercholesterolemia
Hyperlipidemia
Mixed hyperlipidemia
Treatment to slow progression of coronary artery disease
Professional Synonyms:
Atherosclerosis
Atherosclerotic vascular disease
Cardiovascular disease related to atherosclerosis
Combined hypercholesterolemia and hypertriglyceridemia
Elevated blood cholesterol level
Familial heterozygous hypercholesterolemia
Heterozygous familial elevated blood cholesterol
Hyperlipoidemia
Lipemia
Lipidemia
Lipoidemia
Mixed dyslipidemia
Treatment to slow progression of CAD
Indications:
Atherosclerotic cardiovascular disease
Heterozygous familial hypercholesterolemia
Hypercholesterolemia
Hyperlipidemia
Mixed hyperlipidemia
Treatment to slow progression of coronary artery disease
Professional Synonyms:
Atherosclerosis
Atherosclerotic vascular disease
Cardiovascular disease related to atherosclerosis
Combined hypercholesterolemia and hypertriglyceridemia
Elevated blood cholesterol level
Familial heterozygous hypercholesterolemia
Heterozygous familial elevated blood cholesterol
Hyperlipoidemia
Lipemia
Lipidemia
Lipoidemia
Mixed dyslipidemia
Treatment to slow progression of CAD
The following dosing information is available for FLUVASTATIN SODIUM (fluvastatin sodium):
Dosage of fluvastatin sodium is expressed in terms of fluvastatin and must be carefully adjusted according to individual requirements (i.e., percent reduction in LDL-cholesterol concentrations) and response.
Immediate-release capsules: For the reduction in risk of cardiovascular events in adults, the usual recommended starting dosage of fluvastatin is 40 mg once daily in the evening or 40 mg twice daily. The recommended dosing range of fluvastatin immediate-release is 20-80 mg per day.
Extended-release tablets: Fluvastatin extended-release is only available as an 80 mg tablet; the dosage cannot be titrated. The recommended dosage of fluvastatin (as extended-release tablets) in adults is 80 mg once daily. For patients that require a high-intensity statin or are unable to achieve their LDL-cholesterol goal receiving fluvastatin extended-release 80 mg daily, an alternative LDL-cholesterol lowering treatment is recommended.
The AHA/ACC cholesterol management guideline states that the appropriate intensity of statin therapy should be used to reduce ASCVD risk. The guideline recommends use of high-intensity statin therapy (defined as reducing LDL-cholesterol concentrations byat least 50%); if high-intensity statin therapy is not possible (e.g., because of a contraindication or intolerable adverse effect), moderate-intensity statin therapy (defined as reducing LDL-cholesterol concentrations by 30-49%) should be used. The AHA/ACC guideline panel considers fluvastatin 40 mg twice daily (or extended-release fluvastatin 80 mg daily) to be a moderate-intensity statin.
Immediate-release capsules: Therapy with fluvastatin generally is initiated with a dosage of 20 mg daily (as immediate-release capsules) in adults who require reductions in LDL-cholesterol of less than 25%. In patients who require larger reductions in LDL-cholesterol concentrations (i.e., 25% or more) or in patients with primary hypercholesterolemia or mixed dyslipidemia, fluvastatin should be initiated at a dosage of 40 mg daily in the evening or 40 mg twice daily (as immediate-release capsules); administration of two 40-mg immediate-release capsules at one time should be avoided. Dosage should be increased at intervals of no less than 4 weeks until the desired effect on lipoprotein concentrations is observed or a maximum dosage of 80 mg daily is reached.
The usual maintenance dosage of fluvastatin in adults is 20-80 mg daily.
Extended-release tablets: The recommended dosage of fluvastatin (as extended-release tablets) in adults is 80 mg once daily.
Immediate-release capsules: The recommended initial dosage of fluvastatin for the treatment of heterozygous familial hypercholesterolemia in boys and postmenarchal girls 10-16 years of age is 20 mg once daily. Dosage should be increased at 6-week intervals until the desired effect on lipoprotein concentrations is observed or a maximum dosage of 80 mg daily (administered as 40 mg twice daily as immediate-release capsules or 80 mg once daily as extended-release tablets) is reached.
Extended-release fluvastatin tablets cannot be used for dosage initiation in pediatric patients, but may be used once the patient reaches a dosage of 80 mg daily after titration with the immediate-release capsules.
In patients receiving cyclosporine or fluconazole, the manufacturer recommends that fluvastatin dosage not exceed 20 mg twice daily.
Immediate-release capsules: For the reduction in risk of cardiovascular events in adults, the usual recommended starting dosage of fluvastatin is 40 mg once daily in the evening or 40 mg twice daily. The recommended dosing range of fluvastatin immediate-release is 20-80 mg per day.
Extended-release tablets: Fluvastatin extended-release is only available as an 80 mg tablet; the dosage cannot be titrated. The recommended dosage of fluvastatin (as extended-release tablets) in adults is 80 mg once daily. For patients that require a high-intensity statin or are unable to achieve their LDL-cholesterol goal receiving fluvastatin extended-release 80 mg daily, an alternative LDL-cholesterol lowering treatment is recommended.
The AHA/ACC cholesterol management guideline states that the appropriate intensity of statin therapy should be used to reduce ASCVD risk. The guideline recommends use of high-intensity statin therapy (defined as reducing LDL-cholesterol concentrations byat least 50%); if high-intensity statin therapy is not possible (e.g., because of a contraindication or intolerable adverse effect), moderate-intensity statin therapy (defined as reducing LDL-cholesterol concentrations by 30-49%) should be used. The AHA/ACC guideline panel considers fluvastatin 40 mg twice daily (or extended-release fluvastatin 80 mg daily) to be a moderate-intensity statin.
Immediate-release capsules: Therapy with fluvastatin generally is initiated with a dosage of 20 mg daily (as immediate-release capsules) in adults who require reductions in LDL-cholesterol of less than 25%. In patients who require larger reductions in LDL-cholesterol concentrations (i.e., 25% or more) or in patients with primary hypercholesterolemia or mixed dyslipidemia, fluvastatin should be initiated at a dosage of 40 mg daily in the evening or 40 mg twice daily (as immediate-release capsules); administration of two 40-mg immediate-release capsules at one time should be avoided. Dosage should be increased at intervals of no less than 4 weeks until the desired effect on lipoprotein concentrations is observed or a maximum dosage of 80 mg daily is reached.
The usual maintenance dosage of fluvastatin in adults is 20-80 mg daily.
Extended-release tablets: The recommended dosage of fluvastatin (as extended-release tablets) in adults is 80 mg once daily.
Immediate-release capsules: The recommended initial dosage of fluvastatin for the treatment of heterozygous familial hypercholesterolemia in boys and postmenarchal girls 10-16 years of age is 20 mg once daily. Dosage should be increased at 6-week intervals until the desired effect on lipoprotein concentrations is observed or a maximum dosage of 80 mg daily (administered as 40 mg twice daily as immediate-release capsules or 80 mg once daily as extended-release tablets) is reached.
Extended-release fluvastatin tablets cannot be used for dosage initiation in pediatric patients, but may be used once the patient reaches a dosage of 80 mg daily after titration with the immediate-release capsules.
In patients receiving cyclosporine or fluconazole, the manufacturer recommends that fluvastatin dosage not exceed 20 mg twice daily.
No enhanced Administration information available for this drug.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| FLUVASTATIN SODIUM 20 MG CAP | Maintenance | Adults take 1 capsule (20 mg) by oral route once daily |
| FLUVASTATIN SODIUM 40 MG CAP | Maintenance | Adults take 1 capsule (40 mg) by oral route once daily in the evening |
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| FLUVASTATIN SODIUM 20 MG CAP | Maintenance | Adults take 1 capsule (20 mg) by oral route once daily |
| FLUVASTATIN SODIUM 40 MG CAP | Maintenance | Adults take 1 capsule (40 mg) by oral route once daily in the evening |
The following drug interaction information is available for FLUVASTATIN SODIUM (fluvastatin sodium):
There are 4 contraindications.
These drug combinations generally should not be dispensed or administered to the same patient. A manufacturer label warning that indicates the contraindication warrants inclusion of a drug combination in this category, regardless of clinical evidence or lack of clinical evidence to support the contraindication.
| Drug Interaction | Drug Names |
|---|---|
| Fluvastatin (Greater Than 20 mg BID); Pitavastatin; Pravastatin (Greater Than 20 mg); Rosuvastatin (Greater Than 5 mg); Simvastatin/Cyclosporine SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: Cyclosporine is a CYP3A4, P-glycoprotein, and OATP inhibitor, while statins are CYP3A4, P-glycoprotein, and OATP substrates. (18,30) When a statin is combined with cyclosporine, statin clearance is reduced and elevated statin concentrations remain in the peripheral blood and muscle cells.(31) CLINICAL EFFECTS: Myopathy and muscle aches, tenderness and weakness (rhabdomyolysis) may occur with concurrent administration of HMG-CoA reductase inhibitors and cyclosporine. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The dosage of fluvastatin should not exceed 20 mg BID in patients receiving cyclosporine.(1) The concurrent use of pitavastatin with cyclosporine is contraindicated.(2) The dosage of pravastatin should not exceed 20 mg in patients receiving cyclosporine.(3) The dosage of rosuvastatin should not exceed 5 mg in patients receiving cyclosporine.(4) The concurrent use of simvastatin with cyclosporine is contraindicated.(5-7) Patients receiving concurrent therapy should be instructed to report symptoms of muscle pain/tenderness/weakness, fever, unusual tiredness, and/or a change in the amount of urine. DISCUSSION: Since this reaction may occur with HMG-CoA-reductase inhibitors alone, a causal relationship is difficult to establish. However, the incidence of myopathy and rhabdomyolysis appears to increase with concurrent administration of cyclosporine. In a study, administration of a single dose of cyclosporine (2 mg/kg) on Day 6 of pitavastatin (2 mg daily) increased the AUC and Cmax of pitavastatin by 4.6-fold and 6.6-fold, respectively.(2) In a study, administration of pravastatin in 11 heart transplant patients receiving cyclosporine was compared to 8 control subjects not receiving cyclosporine. Pravastatin AUC and Cmax were 7-8-fold and 12-fold higher, respectively, in subjects taking cyclosporine.(8) In a double-blind, randomized, cross-over study in 44 renal transplant patients, neither lovastatin nor pravastatin affected cyclosporine levels. Pravastatin levels after 1 day and after 28 days of concurrent therapy were 5-fold higher than historical controls. Lovastatin levels accumulated over the course of the study and by Day 28 were 20-fold higher than historical controls.(9) In a study in 31 renal transplant patients, neither pravastatin nor simvastatin affected cyclosporine levels.(10) In contrast, in a study in 44 heart transplant subjects, cyclosporine clearance was increased following the addition of simvastatin.(11) In a study, a single dose of cyclosporine (5 mg/kg) increased the Cmax and AUC of a single dose of pravastatin (40 mg) by 327% and 282%, respectively.(3) Several studies have found no effect from fluvastatin on cyclosporine pharmacokinetics.(12-16) One of these also noted no affects of cyclosporine on fluvastatin levels.(12) In contrast, a study that compared the administration of fluvastatin in 10 heart transplant to 10 healthy control subjects found that fluvastatin AUC and Cmax were 2.55-fold and 3.10-fold higher than in control subjects.(17) In another study, stable cyclosporine doses increased the Cmax and AUC of fluvastatin (20 mg daily for 14 weeks) by 30% and 90%, respectively.(1) In an open-label study in 10 heart transplant patients, concurrent cyclosporine increased rosuvastatin AUC and Cmax by 7.1-fold and 10.6-fold, respectively, when compared to historical controls. There were no effects on cyclosporine levels.(4,18) Rhabdomyolysis has been reported with concurrent cyclosporine and lovastatin(19-23) and simvastatin.(24-29) |
CYCLOSPORINE, CYCLOSPORINE MODIFIED, GENGRAF, NEORAL, SANDIMMUNE |
| Fluvastatin (Greater Than 20 mg BID)/Fluconazole SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: Fluconazole may inhibit the metabolism of fluvastatin by CYP2C9.(1) CLINICAL EFFECTS: Concurrent use of fluconazole may result in elevated levels of fluvastatin and rhabdomyolysis. PREDISPOSING FACTORS: Patients with a SLCO1B1 polymorphism that leads to decreased or poor function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: Do not use fluvastatin in doses greater than 20 mg twice daily in patients receiving fluconazole. DISCUSSION: In a study in 12 healthy subjects, pretreatment with fluconazole (400 mg Day 1, 200 mg/day on Days 2-4) increased fluvastatin area-under-curve (AUC) and maximum concentration (Cmax) by 84% and 44%, respectively.(1,2) Fluvastatin half-life increased by 80%.(2) |
DIFLUCAN, FLUCONAZOLE, FLUCONAZOLE-NACL |
| Fluvastatin/Gemfibrozil SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: Unknown. CLINICAL EFFECTS: Concurrent administration of HMG-CoA reductase inhibitors and fibric acid derivatives has been associated with severe myopathy, rhabdomyolysis and acute renal failure. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: According to the 2018 ACC/AHA Blood Cholesterol Guidelines, gemfibrozil is contraindicated in patients on statin therapy. According to the 2016 AHA Scientific Statement Recommendations for Management of Clinically Significant Drug-Drug Interactions with Statins and Select Agents Used in Patients with Cardiovascular Disease, fluvastatin dose does not require a dose adjustment when used concurrently with gemfibrozil. According to 2013 ACC/AHA Blood Cholesterol Guidelines, gemfibrozil should not be initiated in patients on statin therapy. Fenofibrate may be considered with low or moderate intensity statin therapy only if benefits outweigh the risks. The US, Australian, Canadian, and UK manufacturers of gemfibrozil state that use with HMG CO-A reductase inhibitors does not outweigh the risks of severe myopathy, rhabdomyolysis, and acute renal failure. The Canadian manufacturer of gemfibrozil states that HMG CO-A reductase inhibitors should not be used concurrently. The US manufacturer of fluvastatin states that concurrent use of gemfibrozil should be avoided. The Australian, Canadian, and UK manufacturers state concurrent use should be approached with caution. Instruct patients receiving concurrent therapy to report any unexplained muscle pain, tenderness or weakness. If muscular symptoms develop, monitor serum creatine kinase levels and renal function. One or both agents may need to be discontinued. DISCUSSION: Gemfibrozil has been shown to increase levels of cerivastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin. Administration of gemfibrozil with cerivastatin, lovastatin, and simvastatin has been associated with myolysis and rhabdomyolysis (muscle pain, tenderness, and weakness). Although the reaction has been reported with the statins alone, the incidence increases dramatically with concurrent administration of gemfibrozil. The risk of rhabdomyolysis with concurrent fibrate and HMG CoA reductase inhibitor therapy appears to be greater with gemfibrozil. Analysis of the FDA Adverse Event Report database indicates that the rate is 30 times higher with gemfibrozil than with fenofibrate. In an analysis of data from the Veteran's Administration over a 2 year period, there were 149 reports of rhabdomyolysis in 93,677 (0.16%) patients receiving concurrent gemfibrozil and statin therapy compared with no reports in 1,830 patients receiving concurrent fenofibrate and statin therapy. In a retrospective cohort study of 252,460 patients, concurrent use of statins and fibrates increased the risk of rhabdomyolysis, especially in patients with diabetes mellitus. The risk of hospitalization for patients aged 65 or older with diabetes mellitus, treated with a statin and fibrate, increased 48-fold compared to statin monotherapy. In a retrospective study, of 468 patients with a diagnosis of myopathy, 61 received a statin prior to their diagnosis. Forty-one of these patients developed confirmed myopathy, creatinine kinase more than or equal to 1000 IU/L. |
GEMFIBROZIL, LOPID |
| Fluvastatin (Greater Than 20 mg); Lovastatin (Greater Than 20 mg); Simvastatin (Greater Than 20 mg)/Elbasvir-Grazoprevir SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: Elbasvir-grazoprevir may inhibit intestinal BCRP, resulting in increased absorption of simvastatin. The mechanism of interaction with fluvastatin and lovastatin is not known, but may be related to competitive inhibition of OATP1B1 by elbasvir-grazoprevir.(1-3) CLINICAL EFFECTS: Concurrent use of elbasvir-grazoprevir may result in elevated levels of and toxicity from fluvastatin, lovastatin, and simvastatin, including rhabdomyolysis.(1-3) PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The Canadian and UK manufacturers of elbasvir-grazoprevir and of simvastatin recommend that, in patients requiring elbasvir-grazoprevir, doses greater than 20 mg daily of fluvastatin, lovastatin, or simvastatin should not be used.(1,2) The US manufacturer of elbasvir-grazoprevir states that the lowest possible dose of fluvastatin, lovastatin, or simvastatin should be used.(3) If concurrent use is deemed medically necessary, instruct patients to report symptoms of muscle pain, tenderness, or weakness. DISCUSSION: Elbasvir-grazoprevir is a substrate of OATP1B1 and has been shown to inhibit intestinal BCRP.(1,3) Fluvastatin and lovastatin are substrates of OATP1B1 and simvastatin is a substrate of BCRP and OATP1B1.(4) Studies with other statins (i.e., atorvastatin, rosuvastatin) have shown that elbasvir-grazoprevir can increase the concentrations of these statins. While interaction studies of elbasvir-grazoprevir with fluvastatin, lovastatin, and simvastatin have not been done, fluvastatin and lovastatin concentrations have been shown to increase with other OATP1B1 inhibitors, and simvastatin levels have been shown to increase with other BCRP inhibitors.(4) |
ZEPATIER |
There are 4 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| HMG-CoA Reductase Inhibitors/Niacin (Greater Than or Equal To 250 mg) SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Unknown. CLINICAL EFFECTS: Myopathy and rhabdomyolysis (muscle aches, tenderness, and weakness) have been associated with concomitant administration of HMG-CoA reductase inhibitors and niacin. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The benefit of further alterations in lipid levels with combined use of statins and lipid-lowering dosages of niacin (<= 1000 mg/day) should be carefully weighed against the potential risks.(1-10) The US manufacturer of simvastatin states that dosages of niacin should not exceed 1000 mg daily in patients of Chinese descent.(6) DISCUSSION: The risk of myopathy is increased during concurrent use of HMG-CoA reductase inhibitors and niacin.(1-10) Concomitant administration of niacin with the immediate release formulation of fluvastatin had no effect on fluvastatin pharmacokinetics. Myopathy was not observed in a trial of concurrent fluvastatin and niacin in 74 patients. Concurrent fluvastatin and niacin results in additive effects on total cholesterol and LDL cholesterol.(9) In uncontrolled studies, most subjects who developed myopathy while on lovastatin were also taking cyclosporine, gemfibrozil, or niacin.(1) However, a systematic review showed comparable rates of adverse event reports (AERs) including serious adverse events, hepatotoxicity, or rhabdomyolysis for the combination of lovastatin with niacin-extended release (ER) pill relative to either agent alone or to other statins. Therefore, these results did not support a clinically significant adverse drug interaction between niacin-ER and statins.(14) In clinical trials involving small numbers of patients, no myopathy was reported with concurrent pravastatin and niacin.(10) There are case reports of myopathy during concurrent lovastatin and niacin.(2,11,12) Interim HPS2 results showed a higher rate of myopathy in patients of Chinese descent (0.43%) when compared to patients of non-Chinese descent (0.03%) in patients taking simvastatin (40 mg) with cholesterol-lowering doses of niacin.(7) Kosoglou suggests that there is a small pharmacokinetic drug interaction between ER niacin and ezetimibe/simvastatin but is not clinically significant.(15) However, the HPS2-THRIVE showed a significant four-fold excess risk of myopathy with the addition of ER niacin 2g plus laropiprant 40mg daily (ERN/LRPT) to simvastatin 40mg daily (with or without ezetimibe 10mg daily). This additional risk is particularly prevalent among Chinese descent versus European descent.(16) The AIM-HIGH trial randomized 3414 patients to receive niacin extended-release 1500-2000 mg per day or placebo in addition to current therapy of simvastatin 40-80 mg per day and ezetimibe 10 mg per day if needed to achieve a goal LDL of 40-80 mg/dL. Patients were followed for a mean of 3 years. The primary efficacy endpoint of composite of the first event of death from coronary heart disease, nonfatal myocardial infarction, ischemic stroke, hospitalization (greater than 23 hours) for an acute coronary syndrome, or symptom-driven coronary or cerebral vascularization, occurred in 16.4% of patients in the niacin group and 16.2% of patients in the placebo group (p=0.80).(17) The HPS2-THRIVE trial randomized 25,673 patients to receive extended-release niacin 2000 mg with laropiprant 40 mg per day or placebo in addition to current therapy of simvastatin 40 mg per day. Patients were followed for a median of 3.9 years. The primary efficacy endpoint of first major vascular event, defined as a major coronary event (nonfatal myocardial infarction or death from coronary causes), stroke of any type, or coronary or noncoronary vascularization, occurred in 13.2% of patients in the niacin-laropiprant group and 13.7% of patients in the placebo group (p=0.29).(18) A post-hoc analysis of the AIM-HIGH trial showed significant lowering of triglycerides (59 mg/dL) in the extended-release niacin (ERN) group compared to the placebo group (20mg/dL). High density lipoprotein levels showed improvement in the ERN group compared to the placebo (11.3mg/dL vs. 4.7 mg/dL, respectively). The incidence of cardiovascular disease events was similar in both groups. However, all-cause mortality was significantly higher in the ERN group (15.4%) versus the control group (9.2%).(19) A meta-analysis investigating the effects of niacin for primary and secondary prevention of cardiovascular events suggests that niacin does not reduce mortality or rates of myocardial infarctions or strokes. Increased side effects are reported with niacin. Benefits from niacin therapy in the prevention of cardiovascular disease events are unlikely.(20) The AIM HIGH trial investigated the effects of ERN added to simvastatin/ezetimibe on glucose and insulin values. ERN increased fasting glucose from baseline to 1 year in patients with normal (7.9 vs 4.3 mg/dL, respectively) and impaired fasting glucose (4.1 vs 1.4 mg/dL, respectively). There was an increased risk of progressing from normal to impaired fasting glucose in the ERN (58.6% cases) versus placebo (41.5% cases).(21) One or more of the drug pairs linked to this monograph have been included in a list of interactions that could be considered for classification as "non-interruptive" in EHR systems. This DDI subset was vetted by an expert panel commissioned by the U.S. Office of the National Coordinator (ONC) for Health Information Technology. |
NIACIN, NIACIN ER, NIACOR, NICOTINIC ACID |
| HMG-CoA Reductase Inhibitors/Daptomycin SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: The exact mechanism is unknown but may involve additive or synergistic effects on skeletal muscle. CLINICAL EFFECTS: Concurrent use of HMG-CoA reductase inhibitors and daptomycin can result in elevated creatinine phosphokinase (CPK) levels and skeletal muscle effects.(1) PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The manufacturer of daptomycin recommends considering suspending HMG-CoA reductase inhibitor therapy in patients receiving daptomycin. CPK levels should be monitored more frequently than the weekly standard frequency in patients who have recently received HMG-CoA reductase therapy or in whom concurrent therapy is warranted. Closely monitor patients for the development of muscle pain and/or weakness.(1) DISCUSSION: In the Phase 3 Staphylococcus aureus bacteremia/endocarditis trial, 5 of 22 patients who received prior or concurrent HMG Co-A reductase inhibitor therapy developed CPK elevations greater than 500 U/L. At a dose of 6 mg/kg of daptomycin, a total of 11 patients developed CPK elevations greater than 500 U/L. Of these, 4 had prior or concurrent HMG Co-A reductase therapy. Rhabdomyolysis in patients treated concurrently with HMG Co-A reductase inhibitors has been reported in post-marketing experience.(1) In 20 healthy subjects, concurrent simvastatin (40 mg daily) and daptomycin (4 mg/kg daily) was not associated with a higher incidence of adverse effects when compared to 10 subjects receiving placebo.(1) |
DAPTOMYCIN, DAPTOMYCIN-0.9% NACL |
| Selected CYP2C9 Substrates/Asciminib SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Asciminib is a moderate inhibitor of CYP2C9.(1) Asciminib may decrease the metabolism of drugs that are CYP2C9 substrates. CLINICAL EFFECTS: Decreased clearance may increase systemic concentrations of drugs primarily metabolized by CYP2C9, leading to toxicity.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The manufacturer of asciminib states coadministration of the CYP2C9 substrate drug with asciminib should be avoided. Consider an alternative agent that does not depend on CYP2C9 for metabolism. If a patient is taking asciminib 80 mg total daily dose and coadministration of the CYP2C9 substrate is unavoidable, reduce the dosage of the CYP2C9 substrate according to its product labeling.(1) Closely monitor patients stable on CYP2C9 substrates for altered therapeutic effect or toxicity when asciminib therapy is started, adjusted, or stopped.(1) DISCUSSION: In clinical studies, coadministration of asciminib 40 mg twice daily, 80 mg once daily, and 200 mg twice daily, the area-under-the-curve (AUC) of S-warfarin increased by 41%, 52%, and 314%, respectively. Additionally, the maximum concentration (Cmax) of S-warfarin increased by 8%, 4%, and 7%, respectively.(1) Medications linked to this interaction include fluvastatin, fosphenytoin, glimepiride, glipizide, phenytoin, and tolbutamide. These drugs have a narrow therapeutic range or are designated as CYP2C9 Sensitive Substrates (i.e. moderate 2C9 inhibitors are expected to increase exposure (AUC) to these agents by 2-fold to 5-fold).(2,3) |
SCEMBLIX |
| HMG-CoA Reductase Inhibitors/Belumosudil SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: HMG-CoA reductase inhibitors are substrates of the BCRP and OATP1B1 transporters.(1-7) Belumosudil may increase the absorption and decrease the hepatic uptake and metabolism of HMG-CoA reductase inhibitors by inhibiting OATP1B1 and BCRP transporters.(7,8) CLINICAL EFFECTS: Simultaneous use of belumosudil may result in increased levels and side effects from HMG-CoA reductase inhibitors, including rhabdomyolysis.(8) PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The US and Australian manufacturers of belumosudil state that concurrent use of BCRP and OATP1B1 substrates for which minimal concentration changes may lead to serious toxicities should be avoided.(8-9) If coadministration cannot be avoided, lower the dose of the HMG-CoA reductase inhibitor according to its labeling recommendations.(9) DISCUSSION: Coadministration of belumosudil increased rosuvastatin (OATP1B1 and BCRP substrate) maximum concentration (Cmax) and area-under-curve (AUC) by 3.6- and 4.6-fold, respectively.(8) |
REZUROCK |
There are 14 moderate interactions.
The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.
| Drug Interaction | Drug Names |
|---|---|
| Selected Anticoagulants (Vitamin K antagonists)/Selected HMG-CoA Reductase Inhibitors SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: The exact mechanism of this interaction is unknown. The HMG-CoA reductase inhibitor may inhibit the hepatic hydroxylation of warfarin. The HMG-CoA reductase inhibitors, which are highly plasma protein bound, may displace warfarin from its binding site. CLINICAL EFFECTS: Increased hypoprothrombinemic effects of warfarin may result in a risk for bleeding. PREDISPOSING FACTORS: Risk for bleeding episodes may be greater in patients with disease-associated bleeding risk (e.g. thrombocytopenia). Drug risk factors include concurrent use of multiple drugs which inhibit warfarin metabolism, or have an inherent risk for bleeding (e.g. NSAIDs). PATIENT MANAGEMENT: Patients should be monitored for changes in prothrombin time when a HMG Co-A reductase inhibitor is added to or discontinued from warfarin therapy, or if the dosage of the HMG Co-A reductase inhibitor is adjusted. If concurrent therapy is warranted, monitor patients receiving concurrent therapy for signs of blood loss, including decreased hemoglobin, hematocrit, fecal occult blood, and/or decreased blood pressure and promptly evaluate patients with any symptoms. Discontinue anticoagulation in patients with active pathologic bleeding. Instruct patients to report any signs and symptoms of bleeding, such as unusual bleeding from the gums or nose; unusual bruising; red or black, tarry stools; red, pink or dark brown urine; acute abdominal or joint pain and/or swelling. The time of highest risk for a coumarin-type drug interaction is when the precipitant drug is initiated or discontinued. Contact the prescriber before initiating, altering the dose or discontinuing either drug. DISCUSSION: Case reports in the medical literature and to the manufacturer have documented an interaction between lovastatin and warfarin. A case report has documented an interaction between pravastatin and fluindione (an orally administered indanedione anticoagulant), suggesting that pravastatin could also interact similarly with warfarin. Information concerning a potential interaction with simvastatin is conflicting. A case report has documented an interaction between simvastatin and acenocoumarol while another case report showed no interaction with warfarin. One group of authors reported three case reports of increased international normalized ratios (INRs) following the addition of fluvastatin to warfarin therapy. The addition of rosuvastatin to patients stabilized on warfarin resulted in clinically significant changes in INR. A cohort study identified concurrent use of warfarin with atorvastatin, rosuvastatin, and simvastatin. Concurrent use of warfarin and simvastatin increased INR from 2.4 to 2.71, with INRs peaking at 4 weeks after statin initiation (mean change 0.32 (95% CI 0.25-0.38) and median change 0.2 (IQR -0.3-0.8)). Concurrent use of warfarin with atorvastatin and rosuvastatin increased INR from 2.42 to 2.69 with a mean change of 0.27 (95% CI 0.12-0.42) and from 2.31 to 2.61 with a mean change of 0.3 (95% CI -0.09-0.69), respectively. One or more of the drug pairs linked to this monograph have been included in a list of interactions that could be considered for classification as "non-interruptive" in EHR systems. This DDI subset was vetted by an expert panel commissioned by the U.S. Office of the National Coordinator (ONC) for Health Information Technology. |
ANISINDIONE, JANTOVEN, WARFARIN SODIUM |
| Fluvastatin (Less Than or Equal To 20 mg BID); Pravastatin (Less Than or Equal To 20 mg); Rosuvastatin (Less Than or Equal To 5 mg)/Cyclosporine SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Cyclosporine is a CYP3A4, P-glycoprotein, and OATP inhibitor, while statins are CYP3A4, P-glycoprotein, and OATP substrates. (1,2) When a statin is combined with cyclosporine, statin clearance is reduced and elevated statin concentrations remain in the peripheral blood and muscle cells.(3) CLINICAL EFFECTS: Myopathy and muscle aches, tenderness and weakness (rhabdomyolysis) may occur with concurrent administration of HMG-CoA reductase inhibitors and cyclosporine. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The dosage of fluvastatin should not exceed 20 mg BID in patients receiving cyclosporine.(4) The dosage of pravastatin should not exceed 20 mg in patients receiving cyclosporine.(5) The dosage of rosuvastatin should not exceed 5 mg in patients receiving cyclosporine.(6) Patients receiving concurrent therapy should be instructed to report symptoms of muscle pain, tenderness, or weakness. DISCUSSION: Since this reaction may occur with HMG-CoA-reductase inhibitors alone, a causal relationship is difficult to establish. However, the incidence of myopathy and rhabdomyolysis appears to increase with concurrent administration of cyclosporine. In a study, administration of pravastatin in 11 heart transplant patients receiving cyclosporine was compared to 8 control subjects not receiving cyclosporine. Pravastatin AUC and Cmax were 7-8-fold and 12-fold higher, respectively, in subjects taking cyclosporine.(7) In a double-blind, randomized, cross-over study in 44 renal transplant patients, neither lovastatin nor pravastatin affected cyclosporine levels. Pravastatin levels after 1 day and after 28 days of concurrent therapy were 5-fold higher than historical controls. Lovastatin levels accumulated over the course of the study and by Day 28 were 20-fold higher than historical controls.(8) In a study in 31 renal transplant patients, neither pravastatin nor simvastatin affected cyclosporine levels.(9) In contrast, in a study in 44 heart transplant subjects, cyclosporine clearance was increased following the addition of simvastatin.(10) In a study, a single dose of cyclosporine (5 mg/kg) increased the Cmax and AUC of a single dose of pravastatin (40 mg) by 327% and 282%, respectively.(6) Several studies have found no effect from fluvastatin on cyclosporine pharmacokinetics.(11-15) One of these also noted no affects of cyclosporine on fluvastatin levels.(11) In contrast, a study that compared the administration of fluvastatin in 10 heart transplant to 10 healthy control subjects found that fluvastatin AUC and Cmax were 2.55-fold and 3.10-fold higher than in control subjects.(16) In another study, stable cyclosporine doses increased the Cmax and AUC of fluvastatin (20 mg daily for 14 weeks) by 30% and 90%, respectively.(4) In an open-label study in 10 heart transplant patients, concurrent cyclosporine increased rosuvastatin AUC and Cmax by 7.1-fold and 10.6-fold, respectively, when compared to historical controls. There were no effects on cyclosporine levels.(7,17) |
CYCLOSPORINE, CYCLOSPORINE MODIFIED, GENGRAF, NEORAL, SANDIMMUNE |
| Selected HMG-CoA Reductase Inhibitors/Digoxin SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: The exact mechanism is unknown, but may involve competitive inhibition of P-glycoproteins.(1) CLINICAL EFFECTS: Concurrent use of digoxin and a HMG-CoA reductase inhibitor may result in rhabdomyolysis.(1) Concurrent use of atorvastatin(2) or simvastatin(3) may result in increased levels of digoxin. Symptoms of digoxin toxicity can include anorexia, nausea, vomiting, headache, fatigue, malaise, drowsiness, generalized muscle weakness, disorientation, hallucinations, visual disturbances, and arrhythmias. PREDISPOSING FACTORS: Low body weight, advanced age, impaired renal function, hypokalemia, hypercalcemia, and/or hypomagnesemia may increase the risk of digoxin toxicity. The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: Patients receiving concurrent therapy with digoxin and a HMG-CoA reductase inhibitor should be closely monitored for rhabdomyolysis and instructed to report any symptoms of myopathy.(1) Patients receiving concurrent atorvastatin(2) or simvastatin(3) should be monitored for elevated digoxin levels and instructed to report any symptoms of digoxin toxicity. The dosage of digoxin may need to be decreased by 15-30% or the frequency of administration may be reduced.(4) DISCUSSION: A retrospective review examined all reports of HMG-CoA reductase inhibitor-induced rhabdomyolysis submitted to the Food and Drug Administration (FDA) between November, 1997 and March, 2000. There were 601 unique cases of rhabdomyolysis, with 26 cases involving concurrent use of digoxin. There were 5 reports involving concurrent atorvastatin/digoxin, 7 reports with cerivastatin/digoxin, 1 report with fluvastatin/digoxin, 2 with lovastatin/digoxin, 2 with pravastatin/digoxin, and 9 with simvastatin/digoxin.(5) Concurrent use of atorvastatin (80 mg daily for 14 days) with digoxin (0.25mg daily for 20 days) increased digoxin maximum concentration (Cmax) and area-under-curve (AUC) by 20% and 15%, respectively.(2) In a study in 18 subjects, concurrent fluvastatin had no effect on digoxin AUC but digoxin Cmax increased 11%.(6) Concurrent use of lovastatin had no effect on digoxin levels.(7) In a study in 18 subjects, concurrent pravastatin had no effect on digoxin levels.(8) Concurrent use of rosuvastatin had no effect on digoxin levels.(9) Concurrent simvastatin slightly increased the concentration of a single dose of digoxin by less than 0.3 ng/ml.(3) |
DIGITEK, DIGOXIN, DIGOXIN MICRONIZED, LANOXIN, LANOXIN PEDIATRIC |
| Colchicine/HMG-CoA Reductase Inhibitors SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Colchicine and HMG-CoA Reductase Inhibitors(statins) each have a risk for myopathy and rhabdomyolysis; these risks may be additive.(1-3) CLINICAL EFFECTS: Concurrent use of the statin drugs and colchicine may increase the risk of myopathy or rhabdomyolysis, which is characterized by progressive muscle weakness and pain in the presence of a normal neurological exam.(1-8) PREDISPOSING FACTORS: Long term use of colchicine, generally from weeks to months in duration of use, may predispose patients to myopathy or rhabdomyolysis.(1) The risk for myopathy or rhabdomyolysis may also be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: Patients receiving concurrent therapy with colchicine and HMG-CoA reductase inhibitors should be carefully monitored for myopathy or rhabdomyolysis. Patients should be instructed to report any symptoms of myopathy such as unexplained muscle aches, tenderness, weakness, or the onset of tingling/numbness in the fingers or toes.(1-6) DISCUSSION: The development of myopathy and clinical rhabdomyolysis have been reported in several case reports with concurrent use of colchicine and atorvastatin,(4) fluvastatin,(5) pravastatin,(6) simvastatin(7,8), and rosuvastatin.(2) The incidence and frequency appear to increase in patients with mild to moderate renal insufficiency and length of colchicine therapy. |
COLCHICINE, COLCRYS, GLOPERBA, LODOCO, MITIGARE, PROBENECID-COLCHICINE |
| Selected HMG Co-A Reductase Inhibitors/Fluconazole SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Fluconazole(1-2) may inhibit the metabolism of atorvastatin, lovastatin, and simvastatin by CYP3A4. Fluconazole may inhibit the metabolism of fluvastatin by CYP2C9.(3) CLINICAL EFFECTS: Concurrent use of fluconazole(1,2,4-6) or voriconazole(3) may result in elevated levels of atorvastatin, fluvastatin, lovastatin, and simvastatin and rhabdomyolysis. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: Do not use fluvastatin in doses greater than 20 mg twice daily in patients receiving fluconazole.(6) Concurrent use of fluconazole with atorvastatin, fluvastatin, lovastatin, or simvastatin should be approached with caution. Patients should be carefully monitored for and instructed to report any signs of myopathy. Adjustment of the statin dose may be required. DISCUSSION: In a study in 12 healthy subjects, pretreatment with fluconazole (400 mg Day 1, 200 mg/day on Days 2-4) increased fluvastatin area-under-curve (AUC) and maximum concentration (Cmax) by 84% and 44%, respectively.(3,5) Fluvastatin half-life increased by 80%.(3) There are four case reports of rhabdomyolysis following the addition of fluconazole to patients previously stabilized on simvastatin therapy(1,4,8,9) and one case report of rhabdomyolysis during concurrent fluconazole and atorvastatin.(6) In a randomized, double-blind, cross-over study in 14 healthy males, pretreatment with fluconazole (200 mg daily for 11 days) increased the AUC and Cmax of a single dose of rosuvastatin (80 mg on Day 8) by 14% and 9%, respectively. These changes were not considered clinically significant.(7) In a PKPB model, concurrent use of atorvastatin (40 mg daily) with fluconazole (400 mg daily for 5 days) increased the simulated Cmax ratio and AUC ratio of atorvastatin by 1.42 and 2.17, respectively, and increased the simulated Cmax ratio and AUC ratio of atorvastatin lactone by 2.94 and 3.82, respectively.(10) One or more of the drug pairs linked to this monograph have been included in a list of interactions that should be considered "high-priority" for inclusion and should not be inactivated in EHR systems. This DDI subset was vetted by an expert panel commissioned by the U.S. Office of the National Coordinator (ONC) for Health Information Technology. |
DIFLUCAN, FLUCONAZOLE, FLUCONAZOLE-NACL |
| Atorvastatin; Fluvastatin/Voriconazole SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Voriconazole may inhibit the metabolism of atorvastatin by CYP3A4.(1) Voriconazole may inhibit the metabolism of fluvastatin by CYP2C9.(1) CLINICAL EFFECTS: Concurrent use of voriconazole(1) may result in elevated levels of atorvastatin and fluvastatin and increase the risk of rhabdomyolysis. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: Concurrent use of voriconazole with atorvastatin or fluvastatin should be approached with caution. Consider adjusting the dose of the statin to use the lowest dose possible(2,3) or possibly suspending therapy during antifungal treatment. Patients should be carefully monitored for and instructed to report any signs of myopathy. DISCUSSION: Voriconazole has been shown to inhibit the metabolism of lovastatin in human liver microsomes in vitro. Voriconazole has also been shown to inhibit CYP2C9 metabolism.(1) |
VFEND, VFEND IV, VORICONAZOLE |
| Phenytoin/Fluvastatin SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Fluvastatin may inhibit the metabolism of phenytoin by CYP2C19.(1) CLINICAL EFFECTS: Concurrent use of fluvastatin may result in elevated levels of and toxicity from phenytoin.(2) Phenytoin has a narrow therapeutic range. Early symptoms of phenytoin toxicity may include nystagmus, ataxia, dysarthria, tremor, hyperreflexia, lethargy, slurred speech, blurred vision, nausea, and vomiting. Severe toxicity may produce organ dysfunction (e.g. coma, irreversible cerebellar dysfunction and atrophy, hypotension, bradycardia, seizures, and cardiac arrest) and may be fatal.(3) PREDISPOSING FACTORS: Renal impairment, hepatic impairment, or hypoalbuminemia. PATIENT MANAGEMENT: Phenytoin levels should be monitored if fluvastatin is initiated or discontinued or if fluvastatin dosage adjustments are made. The dosage of phenytoin may need to be adjusted. Monitor the patient for signs of hydantoin toxicity (e.g. nystagmus, ataxia, dysarthria, tremor, hyperreflexia, lethargy, slurred speech, blurred vision, nausea, and vomiting). DISCUSSION: In a study, fluvastatin (40 mg daily for 5 days) increased the maximum concentration (Cmax) and area-under-curve (AUC) of phenytoin (300 mg daily) by 5% and 20%, respectively.(2) In a study, phenytoin (300 mg daily) increased the Cmax and AUC of fluvastatin (40 mg BID) by 27% and 40%, respectively; however, this was not viewed as clinically significant.(2) |
CEREBYX, DILANTIN, DILANTIN-125, FOSPHENYTOIN SODIUM, PHENYTEK, PHENYTOIN, PHENYTOIN SODIUM, PHENYTOIN SODIUM EXTENDED |
| Selected HMG-CoA Reductase Inhibitors/Fenofibrate SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Unknown. CLINICAL EFFECTS: Concurrent administration of HMG-CoA reductase inhibitors and fibric acid derivatives has been associated with severe myopathy, rhabdomyolysis and acute renal failure. PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: When possible, avoid administration of these drugs concomitantly unless patients require aggressive therapy. Instruct patients to report any unexplained muscle pain, tenderness or weakness. If muscular symptoms develop, monitor serum creatine kinase levels and renal function. One or both agents may need to be discontinued. The American College of Cardiology and American Heart Association Guidelines state that fenofibrate may be considered concomitantly with a low- or moderate-intensity statin only if the benefits from atherosclerotic cardiovascular risk reduction or triglyceride lowering when triglycerides are greater than or equal to 500 mg/dL are judged to outweigh the potential risk for adverse effects.(20) The European Society of Cardiology and European Atherosclerosis Society recommend concomitant statin-fenofibrate therapy in patients with atherogenic combined dyslipidemia, especially patients with metabolic syndrome and/or diabetes.(21) The US manufacturer of fenofibrate states that concurrent therapy with HMG CO-A reductase inhibitors should be avoided unless the benefit of further decreases in lipid levels is likely to outweigh the increased risk. Fenofibrate may be preferred over gemfibrozil in patients who do require concurrent statin and fibrate therapy.(9) The manufacturer of pravastatin states that concurrent therapy should be avoided unless the benefits of combination therapy outweigh the risks.(6) The Canadian manufacturer of rosuvastatin states that concurrent therapy with other fibrates should be approached with caution. The Australian and UK manufacturers of rosuvastatin state that rosuvastatin 40 mg is contraindicated with concomitant use of fibrates.(27,28) The risks of concurrent use of fibrates should be carefully weighed against the benefits. Patients taking a fibrate should start rosuvastatin therapy with the 5 mg dose. The US manufacturer of rosuvastatin states that the concurrent use of fenofibrate should be carefully weighed against the benefits. In patients receiving concurrent fenofibrate, a dosage reduction of rosuvastatin should be considered.(5) The manufacturer of simvastatin states that concurrent therapy with other fibrates should be approached with caution.(7) DISCUSSION: Concurrent fenofibrate (160 mg daily) increased the AUC and Cmax of pitavastatin (4 mg daily) by 18% and 11%, respectively. Concurrent fenofibrate (145 mg) with pravastatin (40 mg) increased pravastatin Cmax and AUC by 36% (range from 69% decrease to 321% increase) and 28% (range from 54% decrease to 128% increase), respectively, and the 3-alpha-hydroxy-iso-pravastatin Cmax and AUC by 55% (range from 32% decrease to 314% increase) and by 39% (range from 24% decrease to 261% increase), respectively. A single dose of pravastatin had no effect on the kinetics of fenofibrate. In a study in 24 healthy subjects, concurrent fenofibrate (160 mg daily) increased the average AUC of pravastatin (40 mg daily) by 19-28%; however, individual changes were variable and not statistically significant. Concurrent fenofibrate and rosuvastatin resulted in no significant changes in rosuvastatin or fenofibrate levels; however, rhabdomyolysis has been reported during concurrent therapy. Concurrent fenofibrate and simvastatin resulted in no significant changes in simvastatin or fenofibrate levels; however, rhabdomyolysis has been reported during concurrent therapy. In a study in 29 patients, 4 patients reported myalgia during concurrent simvastatin and fenofibrate, compared with no reports during concurrent simvastatin and cholestyramine. The risk of rhabdomyolysis with concurrent fibrate and HMG CoA reductase inhibitor therapy appears to be greater with gemfibrozil. Analysis of the FDA Adverse Event Report database indicates that the rate is 30 times higher with gemfibrozil than with fenofibrate. In an analysis of data from the Veteran's Administration over a 2 year period, there were 149 reports of rhabdomyolysis in 93,677 (0.016%) patients receiving concurrent gemfibrozil and statin therapy compared with no reports in 1,830 patients receiving concurrent fenofibrate and statin therapy. In a study in 66 healthy volunteers, concomitant administration of fenofibrate (160 mg for 7 days) and atorvastatin (40 mg single dose) did not result in a clinically significant change in the atorvastatin AUC.(22) A meta-analysis of 6 randomized controlled trials (including approximately 1600 patients) found no cases of myopathy or rhabdomyolysis in combination therapy of fenofibrate with simvastatin, fluvastatin, or atorvastatin. A comparison of the incidence of creatine kinase greater than 5 times the ULN between combination statin-fenofibrate and statin monotherapy was found to be not significant.(23) A meta-analysis of 13 randomized controlled trials (including approximately 7000 patients) found no significant difference in the incidence of elevated creatine kinase or muscle-associated adverse effects between single-drug statin therapy or combination fenofibrate-statin therapy.(24) The ACCORD trial showed that fenofibrate-simvastatin concomitant therapy had similar rates as simvastatin alone for myopathy, myositis, or rhabdomyolysis.(25) The ACCORD trial was a randomized trial of 5518 patients with type 2 diabetes receiving simvastatin (40 mg per day or less) and either fenofibrate (initial dose of 160 mg per day, dose adjusted for renal function) or placebo. At the mean follow up of 4.7 years, the primary efficacy endpoint of first occurrence of a major cardiovascular event, including nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes, occurred at an annual rate of 2.2% in the fenofibrate group and 2.4 % in the placebo group (p=0.32).(26) Selected HMG-CoA reductase inhibitors linked to this monograph include: fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. |
FENOFIBRATE, FENOFIBRIC ACID, FENOGLIDE, FIBRICOR, LIPOFEN, TRICOR, TRILIPIX |
| HMG Co-A Reductase Inhibitors/Pazopanib SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: The mechanism of interaction is unknown. Statins and pazopanib individually may cause ALT elevations.(1) They share metabolic pathways (CYP3A4) and drug transporters (P-glycoprotein (P-gp), BCRP). Pazopanib is a weak inhibitor of CYP3A4, and the statins inhibit P-gp.(2-5) Their combination may result in elevated drug exposure and toxicity. CLINICAL EFFECTS: Concomitant use of pazopanib and simvastatin is associated with ALT elevations greater than 3 x ULN. Rhabdomyolysis has been reported with the combination of pazopanib and rosuvastatin. Symptoms of rhabdomyolysis include muscle pain, tenderness, weakness, elevated creatine kinase levels, and reddish-brown, heme positive urine. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Consider the risks versus benefits of continuing antilipidemic therapy. Monitor patients receiving concurrent therapy for signs of hepatotoxicity and rhabdomyolysis. The manufacturer of pazopanib states that if ALT elevation occurs in a patient on concomitant simvastatin, pazopanib should be held or discontinued according to recommendations in the pazopanib prescribing information. Alternatively, consider discontinuing simvastatin. There is insufficient data to recommend alternative statins for use in combination with pazopanib.(1) DISCUSSION: A review of 11 pazopanib clinical trials found that ALT elevations greater than 3 x ULN occurred in 27 % (11/41) and 14 % (126/895) of patients with and without concomitant simvastatin, respectively. ALT elevations also occurred more frequently in patients on atorvastatin and on any statin, but the differences were not statistically significant. ALT recovered to less than 2.5 x ULN in all ten patients with follow-up data. Two patients did not have any modification to therapy, while the rest discontinued one or both agents.(2) In a case report, a 73-year-old woman with metastatic renal cell carcinoma presented with rhabdomyolysis, transaminitis, and renal injury six months after starting pazopanib. She had been on rosuvastatin for several years. Pazopanib and rosuvastatin were discontinued and the patient recovered. Rhabdomyolysis due to the combination of rosuvastatin and pazopanib was suspected, though rosuvastatin is primarily metabolized by CYP2C9 and pazopanib is not known to inhibit CYP2C9.(3) |
PAZOPANIB HCL, VOTRIENT |
| Selected CYP2C9 Substrates/Nitisinone SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Nitisinone is a moderate inhibitor of CYP2C9.(1,2) CLINICAL EFFECTS: Decreased clearance may increase systemic concentrations of drugs primarily metabolized by CYP2C9, leading to toxicity.(1,2) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Decrease the dosage of the CYP2C9 substrate drug by one-half. Additional dose adjustments may be necessary. Closely monitor patients stable on CYP2C9 substrates for altered therapeutic effect or toxicity when nitisinone therapy is started or adjusted.(1) DISCUSSION: In a study, 16 healthy subjects who were pre-treated with nitisinone (80 mg daily) for 14 days and received a single dose of tolbutamide (500 mg) had an increase in tolbutamide area-under-curve (AUC) and maximum concentration (Cmax) of 131 % and 16 %, respectively, compared to tolbutamide administered alone.(1,2) Medications linked to this interaction include fluvastatin, fosphenytoin, glimepiride, glipizide, phenytoin, tolbutamide, and warfarin. These drugs have a narrow therapeutic range or are designated as CYP2C9 Sensitive Substrates(3,4) (i.e. moderate 2C9 inhibitors are expected to increase exposure (AUC) to these agents by 2-fold to 5-fold). |
NITISINONE, NITYR, ORFADIN |
| Fluvastatin (Less Than or Equal To 20 mg); Lovastatin (Less Than or Equal To 20 mg); Simvastatin (Less Than or Equal To 20 mg)/Elbasvir-Grazoprevir SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Elbasvir-grazoprevir may inhibit intestinal BCRP, resulting in increased absorption of simvastatin. The mechanism of interaction with fluvastatin and lovastatin is not known, but may be related to competitive inhibition of OATP1B1 by elbasvir-grazoprevir.(1-3) CLINICAL EFFECTS: Concurrent use of elbasvir-grazoprevir may result in elevated levels of and toxicity from fluvastatin, lovastatin, and simvastatin, including rhabdomyolysis.(1-3) PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The Canadian and UK manufacturers of elbasvir-grazoprevir and of simvastatin recommend that, in patients requiring elbasvir-grazoprevir, doses greater than 20 mg daily of fluvastatin, lovastatin, or simvastatin should not be used.(1,2) The US manufacturer of elbasvir-grazoprevir states that the lowest possible dose of fluvastatin, lovastatin, or simvastatin should be used.(3) If concurrent use is deemed medically necessary, instruct patients to report symptoms of muscle pain, tenderness, or weakness. DISCUSSION: Elbasvir-grazoprevir is a substrate of OATP1B1 and has been shown to inhibit intestinal BCRP.(1,3) Fluvastatin and lovastatin are substrates of OATP1B1 and simvastatin is a substrate of BCRP and OATP1B1.(4) Studies with other statins (i.e., atorvastatin, rosuvastatin) have shown that elbasvir-grazoprevir can increase the concentrations of these statins. While interaction studies of elbasvir-grazoprevir with fluvastatin, lovastatin, and simvastatin have not been done, fluvastatin and lovastatin concentrations have been shown to increase with other OATP1B1 inhibitors, and simvastatin levels have been shown to increase with other BCRP inhibitors.(4) |
ZEPATIER |
| Selected HMG-CoA Reductase Inhibitors/Fostemsavir SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Fostemsavir may inhibit OATP1B1 and OATP1B3, resulting in decreased hepatocyte uptake and increased plasma concentrations of atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin.(1) CLINICAL EFFECTS: Concurrent use of fostemsavir may result in elevated levels of and toxicity from atorvastatin, fluvastatin, pitavastatin, rosuvastatin, or simvastatin, including rhabdomyolysis.(1) PREDISPOSING FACTORS: The risk for myopathy or rhabdomyolysis may be greater in patients 65 years and older, inadequately treated hypothyroidism, renal impairment, carnitine deficiency, malignant hyperthermia, or in patients with a history of myopathy or rhabdomyolysis. Patients with a SLCO1B1 polymorphism that leads to decreased function of the hepatic uptake transporter OATP1B1 may have increased statin concentrations and be predisposed to myopathy or rhabdomyolysis. Patients on fluvastatin who are CYP2C9 intermediate or poor metabolizers may have increased fluvastatin concentrations and risk of myopathy. Patients on rosuvastatin with ABCG2 polymorphisms leading to decreased or poor BCRP transporter function may have increased rosuvastatin concentrations and risk of myopathy. PATIENT MANAGEMENT: The manufacturer of fostemsavir states that the lowest possible starting dose of statins should be used. Patients should be monitored for statin-associated adverse events.(1) DISCUSSION: In a study, fostemsavir 600 mg twice daily increased the area-under-curve (AUC) and maximum concentration (Cmax) of single-dose rosuvastatin 10 mg by 1.69-fold and 1.78-fold, respectively.(1) |
RUKOBIA |
| BCRP or OATP1B1 Substrates/Eltrombopag SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Eltrombopag has been shown to inhibit BCRP and OATP1B1.(1-3) Inhibition of BCRP may increase absorption and/or decrease biliary excretion of substrates, while inhibition of OATP1B1 may decrease hepatic uptake of substrates. CLINICAL EFFECTS: Simultaneous use of eltrombopag with BCRP or OATP1B1 substrates may result in increased levels and side effects from the substrates.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The manufacturer of eltrombopag states that concomitant BCRP or OATP1B1 substrates should be used cautiously. Patients on concurrent therapy should be closely monitored for adverse effects, and dose reduction of the substrate should be considered.(1) DISCUSSION: In a clinical trial in 39 healthy subjects, administration of eltrombopag (75 mg daily) increased the area-under-curve (AUC) and maximum concentration (Cmax) of a single dose of rosuvastatin (10 mg, a BCRP and OATP1B1 substrate) by 55% and 103%, respectively.(1,4) In a physiologically-based pharmacokinetic (PBPK) model, eltrombopag 75 mg was predicted to increase the AUC and Cmax of pitavastatin 1 mg by approximately 2-fold.(5) BCRP substrates linked to this monograph include: ciprofloxacin, imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, and topotecan.(1) OATP1B1 substrates linked to this monograph include: atorvastatin, bosentan, fluvastatin, glyburide, irinotecan, letermovir, pitavastatin, pravastatin, repaglinide, and simvastatin.(1) |
ALVAIZ, PROMACTA |
| OATP1B1 Substrates/Midostaurin SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Midostaurin has been shown to inhibit OATP1B1.(1) Inhibition of OATP1B1 may decrease hepatic uptake of substrates. CLINICAL EFFECTS: Simultaneous use of midostaurin with OATP1B1 substrates may result in increased levels and side effects from the substrates.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: The manufacturer of midostaurin states that concomitant OATP1B1 substrates should be used cautiously. Patients on concurrent therapy should be closely monitored for adverse effects as dose adjustments of the substrate may be necessary.(1) DISCUSSION: In a study, single dose midostaurin 100 mg increased the area-under-curve (AUC) of single dose rosuvastatin by 48%. With a 50 mg twice daily dose, midostaurin is predicted to increase the AUC of an OATP1B1 substrate by up to 2-fold.(1) OATP1B1 substrates linked to this monograph include: atorvastatin, bosentan, fluvastatin, glyburide, irinotecan, letermovir, pitavastatin, pravastatin, repaglinide, rosuvastatin and simvastatin. |
RYDAPT |
The following contraindication information is available for FLUVASTATIN SODIUM (fluvastatin sodium):
Drug contraindication overview.
*Hypersensitivity to fluvastatin or any component of the formulation; anaphylaxis, angioedema, and Stevens-Johnson syndrome have been reported. *Immediate-release capsules: Active liver disease or unexplained, persistent elevations of serum transaminases. *Extended-release tablets: Acute liver failure or decompensated cirrhosis.
*Immediate-release capsules: Nursing mothers. The manufacturer states that this formulation is contraindicated in women who are pregnant or may become pregnant; however, because statins may prevent serious or potentially fatal cardiovascular events in certain high-risk patients who are pregnant, FDA has requested that the contraindication in pregnant women be removed from the prescribing information for all statins.
*Hypersensitivity to fluvastatin or any component of the formulation; anaphylaxis, angioedema, and Stevens-Johnson syndrome have been reported. *Immediate-release capsules: Active liver disease or unexplained, persistent elevations of serum transaminases. *Extended-release tablets: Acute liver failure or decompensated cirrhosis.
*Immediate-release capsules: Nursing mothers. The manufacturer states that this formulation is contraindicated in women who are pregnant or may become pregnant; however, because statins may prevent serious or potentially fatal cardiovascular events in certain high-risk patients who are pregnant, FDA has requested that the contraindication in pregnant women be removed from the prescribing information for all statins.
There are 3 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Hepatic failure |
| Lactation |
| Rhabdomyolysis |
There are 7 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Acute renal failure |
| Alcohol use disorder |
| Disease of liver |
| Immune-mediated necrotizing myopathy |
| Intracerebral hemorrhage |
| Myopathy with CK elevation |
| Pregnancy |
There are 3 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Hyperglycemia |
| Memory impairment |
| Myasthenia gravis |
The following adverse reaction information is available for FLUVASTATIN SODIUM (fluvastatin sodium):
Adverse reaction overview.
Adverse effects reported in >=2% of patients, and greater than placebo, receiving immediate-release fluvastatin include headache, dyspepsia, myalgia, abdominal pain, and nausea. Adverse effects reported in >=2.5% of patients, and greater than placebo, receiving extended-release fluvastatin include influenza-like symptoms, sinusitis, dyspepsia, urinary tract infection, bronchitis, and nausea.
Adverse effects reported in >=2% of patients, and greater than placebo, receiving immediate-release fluvastatin include headache, dyspepsia, myalgia, abdominal pain, and nausea. Adverse effects reported in >=2.5% of patients, and greater than placebo, receiving extended-release fluvastatin include influenza-like symptoms, sinusitis, dyspepsia, urinary tract infection, bronchitis, and nausea.
There are 35 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Myalgia |
Atrial fibrillation |
| Rare/Very Rare |
|---|
|
Abnormal hepatic function tests Anaphylaxis Anemia Angioedema Bullous dermatitis Dermatomyositis Diabetes mellitus Dyspnea Eosinophilia Erythema multiforme Hemolytic anemia Hepatic failure Hepatic necrosis Hepatitis Immune-mediated necrotizing myopathy Interstitial lung disease Jaundice Lupus-like syndrome Myopathy Myositis Obstructive hyperbilirubinemia Ocular myasthenia Ophthalmoplegia Pancreatitis Polymyalgia rheumatica Polymyositis Purpura Rhabdomyolysis Stevens-johnson syndrome Thrombocytopenic disorder Toxic epidermal necrolysis Urinary tract infection Vasculitis |
There are 71 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Acute abdominal pain Constipation Diarrhea Dizziness Dyspepsia Headache disorder Heartburn Infection Nausea Skin rash Upper respiratory infection |
Arthralgia Arthritis Back pain Eczema Fatigue Flatulence Flu-like symptoms Gastritis Palpitations Sinusitis |
| Rare/Very Rare |
|---|
|
Acute cognitive impairment Alopecia Anorexia Biliary calculus Blurred vision Bronchitis Cataracts Chest pain Cholecystitis Cough Cramps Depression Disorder of thyroid gland Dry skin Dyschromia Dysesthesia Dysgeusia Dysuria Edema Erectile dysfunction Facial palsy Fever Flushing General weakness Gynecomastia Hyperglycemia Hypoesthesia Increased urinary frequency Insomnia Libido changes Lichen planus Malaise Memory impairment Muscle spasm Muscle weakness Nail disorders Nightmares Nocturia Paresthesia Peripheral neuropathy Pruritus of skin Rhinitis Skin nodules Skin photosensitivity Symptoms of anxiety Tremor Urticaria Vertigo Vomiting Xerostomia |
The following precautions are available for FLUVASTATIN SODIUM (fluvastatin sodium):
Safety and effectiveness of fluvastatin in pediatric patients >=10 years of age (adolescent boys and girls at least one year post-menarche) with heterozygous familial hypercholesterolemia (HeFH) have been established in open-label, uncontrolled studies of 2 years' duration. The most common adverse effects observed were influenza and infections. There were no detectable effects on growth or sexual maturation in boys or on duration of menstrual cycle in girls.
The manufacturer states that pediatric patients receiving fluvastatin in adolescence should be re-evaluated in adulthood, with appropriate adjustments in the antilipemic regimen, to achieve adult treatment goals. Adolescent girls should be advised to use appropriate contraceptive methods during fluvastatin therapy. Safety and efficacy of fluvastatin have not been evaluated in children <10 years of age with HeFH or in children with other types of hyperlipidemia.
However, experts state that statins may be considered in patients as young as 8 years of age in the presence of concerning family history, extremely elevated LDL-cholesterol level, or elevated lipoprotein (a), in the context of informed shared decision-making and counseling with the patient and family. Pharmacokinetic data in the pediatric population are not available.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
The manufacturer states that pediatric patients receiving fluvastatin in adolescence should be re-evaluated in adulthood, with appropriate adjustments in the antilipemic regimen, to achieve adult treatment goals. Adolescent girls should be advised to use appropriate contraceptive methods during fluvastatin therapy. Safety and efficacy of fluvastatin have not been evaluated in children <10 years of age with HeFH or in children with other types of hyperlipidemia.
However, experts state that statins may be considered in patients as young as 8 years of age in the presence of concerning family history, extremely elevated LDL-cholesterol level, or elevated lipoprotein (a), in the context of informed shared decision-making and counseling with the patient and family. Pharmacokinetic data in the pediatric population are not available.
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
All statins were previously contraindicated in pregnant women because the fetal risk with these drugs was thought to outweigh any possible benefit. This determination was based on several factors including safety signals from animal data. Fluvastatin produced delays in skeletal development in rats at doses of 12 mg/kg daily and in rabbits at doses of 10 mg/kg daily (approximately 2 and 5 times, respectively, the human exposure after a 40-mg dose based on mg/m2 surface area).
Malaligned thoracic vertebrae wereobserved in rats at 36 mg/kg, a dose that produced maternal toxicity. Maternal mortality at or near term and postpartum, as well as fetal and neonatal lethality, were observed in female rats receiving fluvastatin 12 and 24 mg/kg daily during the third trimester of pregnancy. In addition, congenital anomalies including severe CNS defects and unilateral limb deficiencies were reported in a case series of pregnant women who were exposed to a lipophilic statin during the first trimester.
Because statins decrease synthesis of cholesterol and possibly other products of the cholesterol biosynthetic pathway, there is also a concern that these drugs can potentially cause fetal harm. More recent data from case series and observational cohort studies have not shown evidence of an increased risk of major birth defects with statin use during pregnancy, and this was observed after controlling for potential confounders such as maternal age, diabetes mellitus, hypertension, obesity, and alcohol and tobacco use. The overall evidence from animal studies suggests limited potential for statins to cause malformations or other adverse fetal effects.
While an increased risk of miscarriage has been reported in pregnant women exposed to statins, it is not clear whether this effect is related to the drugs or to other confounding factors. FDA conducted a comprehensive review of all available clinical and nonclinical data related to statin use in pregnant women and concluded that the totality of evidence suggests limited potential for statins to cause malformations and other adverse embryofetal effects. Because statins may prevent serious or potentially fatal cardiovascular events in certain high-risk patients who are pregnant, FDA has requested that the contraindication in pregnant women be removed from the prescribing information for all statins.
While FDA still advises that most pregnant patients discontinue statins because of the possibility of fetal harm, there may be some patients (e.g., those with homozygous familial hypercholesterolemia or established cardiovascular disease) in whom continued therapy may be beneficial; therefore, decisions should be individualized based on the patient's risks versus benefits. Patients who become pregnant or suspect that they are pregnant while receiving a statin should notify their clinician who can advise them on the appropriate course of action.
Malaligned thoracic vertebrae wereobserved in rats at 36 mg/kg, a dose that produced maternal toxicity. Maternal mortality at or near term and postpartum, as well as fetal and neonatal lethality, were observed in female rats receiving fluvastatin 12 and 24 mg/kg daily during the third trimester of pregnancy. In addition, congenital anomalies including severe CNS defects and unilateral limb deficiencies were reported in a case series of pregnant women who were exposed to a lipophilic statin during the first trimester.
Because statins decrease synthesis of cholesterol and possibly other products of the cholesterol biosynthetic pathway, there is also a concern that these drugs can potentially cause fetal harm. More recent data from case series and observational cohort studies have not shown evidence of an increased risk of major birth defects with statin use during pregnancy, and this was observed after controlling for potential confounders such as maternal age, diabetes mellitus, hypertension, obesity, and alcohol and tobacco use. The overall evidence from animal studies suggests limited potential for statins to cause malformations or other adverse fetal effects.
While an increased risk of miscarriage has been reported in pregnant women exposed to statins, it is not clear whether this effect is related to the drugs or to other confounding factors. FDA conducted a comprehensive review of all available clinical and nonclinical data related to statin use in pregnant women and concluded that the totality of evidence suggests limited potential for statins to cause malformations and other adverse embryofetal effects. Because statins may prevent serious or potentially fatal cardiovascular events in certain high-risk patients who are pregnant, FDA has requested that the contraindication in pregnant women be removed from the prescribing information for all statins.
While FDA still advises that most pregnant patients discontinue statins because of the possibility of fetal harm, there may be some patients (e.g., those with homozygous familial hypercholesterolemia or established cardiovascular disease) in whom continued therapy may be beneficial; therefore, decisions should be individualized based on the patient's risks versus benefits. Patients who become pregnant or suspect that they are pregnant while receiving a statin should notify their clinician who can advise them on the appropriate course of action.
Fluvastatin is distributed into milk in animals, with a milk-to-plasma ratio of 2:1. Because of the potential for serious adverse reactions from fluvastatin in nursing infants, the drug is contraindicated in nursing women; women who require fluvastatin therapy should not breast-feed their infants. Many patients can stop statin therapy temporarily until breast-feeding is complete; patients who require ongoing statin treatment should not breast-feed and should use alternatives such as infant formula.
Fluvastatin generally is well tolerated in geriatric patients. Fluvastatin exposures were not substantially different between geriatric patients (65 years of age or older) and younger patients. However, because advanced age is a predisposing factor for myopathy, fluvastatin should be used with caution in geriatric patients.
Because patients older than 75 years of age may have a higher risk of adverse effects and lower adherence to therapy, the expected benefits versus adverse effects should be considered before initiating statin therapy in this population. Fluvastatin plasma levels are not significantly different in patients > 65 years of age compared to patients 21-49 years of age.
Because patients older than 75 years of age may have a higher risk of adverse effects and lower adherence to therapy, the expected benefits versus adverse effects should be considered before initiating statin therapy in this population. Fluvastatin plasma levels are not significantly different in patients > 65 years of age compared to patients 21-49 years of age.
The following prioritized warning is available for FLUVASTATIN SODIUM (fluvastatin sodium):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for FLUVASTATIN SODIUM (fluvastatin sodium)'s list of indications:
| Atherosclerotic cardiovascular disease | |
| G45 | Transient cerebral ischemic attacks and related syndromes |
| G45.8 | Other transient cerebral ischemic attacks and related syndromes |
| G45.9 | Transient cerebral ischemic attack, unspecified |
| I20 | Angina pectoris |
| I20.0 | Unstable angina |
| I20.2 | Refractory angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I21 | Acute myocardial infarction |
| I21.0 | ST elevation (STEMi) myocardial infarction of anterior wall |
| I21.01 | ST elevation (STEMi) myocardial infarction involving left main coronary artery |
| I21.02 | ST elevation (STEMi) myocardial infarction involving left anterior descending coronary artery |
| I21.09 | ST elevation (STEMi) myocardial infarction involving other coronary artery of anterior wall |
| I21.1 | ST elevation (STEMi) myocardial infarction of inferior wall |
| I21.11 | ST elevation (STEMi) myocardial infarction involving right coronary artery |
| I21.19 | ST elevation (STEMi) myocardial infarction involving other coronary artery of inferior wall |
| I21.2 | ST elevation (STEMi) myocardial infarction of other sites |
| I21.21 | ST elevation (STEMi) myocardial infarction involving left circumflex coronary artery |
| I21.29 | ST elevation (STEMi) myocardial infarction involving other sites |
| I21.3 | ST elevation (STEMi) myocardial infarction of unspecified site |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I22 | Subsequent ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction |
| I22.0 | Subsequent ST elevation (STEMi) myocardial infarction of anterior wall |
| I22.1 | Subsequent ST elevation (STEMi) myocardial infarction of inferior wall |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.8 | Subsequent ST elevation (STEMi) myocardial infarction of other sites |
| I22.9 | Subsequent ST elevation (STEMi) myocardial infarction of unspecified site |
| I23 | Certain current complications following ST elevation (STEMi) and non-ST elevation (NSTEMi) myocardial infarction (within the 28 day period) |
| I23.0 | Hemopericardium as current complication following acute myocardial infarction |
| I23.1 | Atrial septal defect as current complication following acute myocardial infarction |
| I23.2 | Ventricular septal defect as current complication following acute myocardial infarction |
| I23.3 | Rupture of cardiac wall without hemopericardium as current complication following acute myocardial infarction |
| I23.4 | Rupture of chordae tendineae as current complication following acute myocardial infarction |
| I23.5 | Rupture of papillary muscle as current complication following acute myocardial infarction |
| I23.6 | Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarction |
| I23.7 | Postinfarction angina |
| I23.8 | Other current complications following acute myocardial infarction |
| I24.0 | Acute coronary thrombosis not resulting in myocardial infarction |
| I25.1 | Atherosclerotic heart disease of native coronary artery |
| I25.10 | Atherosclerotic heart disease of native coronary artery without angina pectoris |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.111 | Atherosclerotic heart disease of native coronary artery with angina pectoris with documented spasm |
| I25.112 | Atherosclerotic heart disease of native coronary artery with refractory angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.2 | Old myocardial infarction |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.701 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasm |
| I25.702 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with refractory angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.711 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.712 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with refractory angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.721 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.722 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with refractory angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.731 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.732 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with refractory angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.751 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris with documented spasm |
| I25.752 | Atherosclerosis of native coronary artery of transplanted heart with refractory angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.761 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris with documented spasm |
| I25.762 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with refractory angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| I25.791 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.792 | Atherosclerosis of other coronary artery bypass graft(s) with refractory angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.81 | Atherosclerosis of other coronary vessels without angina pectoris |
| I25.810 | Atherosclerosis of coronary artery bypass graft(s) without angina pectoris |
| I25.811 | Atherosclerosis of native coronary artery of transplanted heart without angina pectoris |
| I25.812 | Atherosclerosis of bypass graft of coronary artery of transplanted heart without angina pectoris |
| I25.83 | Coronary atherosclerosis due to lipid rich plaque |
| I25.84 | Coronary atherosclerosis due to calcified coronary lesion |
| I63 | Cerebral infarction |
| I63.0 | Cerebral infarction due to thrombosis of precerebral arteries |
| I63.00 | Cerebral infarction due to thrombosis of unspecified precerebral artery |
| I63.01 | Cerebral infarction due to thrombosis of vertebral artery |
| I63.011 | Cerebral infarction due to thrombosis of right vertebral artery |
| I63.012 | Cerebral infarction due to thrombosis of left vertebral artery |
| I63.013 | Cerebral infarction due to thrombosis of bilateral vertebral arteries |
| I63.019 | Cerebral infarction due to thrombosis of unspecified vertebral artery |
| I63.02 | Cerebral infarction due to thrombosis of basilar artery |
| I63.03 | Cerebral infarction due to thrombosis of carotid artery |
| I63.031 | Cerebral infarction due to thrombosis of right carotid artery |
| I63.032 | Cerebral infarction due to thrombosis of left carotid artery |
| I63.033 | Cerebral infarction due to thrombosis of bilateral carotid arteries |
| I63.039 | Cerebral infarction due to thrombosis of unspecified carotid artery |
| I63.09 | Cerebral infarction due to thrombosis of other precerebral artery |
| I63.11 | Cerebral infarction due to embolism of vertebral artery |
| I63.3 | Cerebral infarction due to thrombosis of cerebral arteries |
| I63.30 | Cerebral infarction due to thrombosis of unspecified cerebral artery |
| I63.31 | Cerebral infarction due to thrombosis of middle cerebral artery |
| I63.311 | Cerebral infarction due to thrombosis of right middle cerebral artery |
| I63.312 | Cerebral infarction due to thrombosis of left middle cerebral artery |
| I63.313 | Cerebral infarction due to thrombosis of bilateral middle cerebral arteries |
| I63.319 | Cerebral infarction due to thrombosis of unspecified middle cerebral artery |
| I63.32 | Cerebral infarction due to thrombosis of anterior cerebral artery |
| I63.321 | Cerebral infarction due to thrombosis of right anterior cerebral artery |
| I63.322 | Cerebral infarction due to thrombosis of left anterior cerebral artery |
| I63.323 | Cerebral infarction due to thrombosis of bilateral anterior cerebral arteries |
| I63.329 | Cerebral infarction due to thrombosis of unspecified anterior cerebral artery |
| I63.33 | Cerebral infarction due to thrombosis of posterior cerebral artery |
| I63.331 | Cerebral infarction due to thrombosis of right posterior cerebral artery |
| I63.332 | Cerebral infarction due to thrombosis of left posterior cerebral artery |
| I63.333 | Cerebral infarction due to thrombosis of bilateral posterior cerebral arteries |
| I63.339 | Cerebral infarction due to thrombosis of unspecified posterior cerebral artery |
| I63.34 | Cerebral infarction due to thrombosis of cerebellar artery |
| I63.341 | Cerebral infarction due to thrombosis of right cerebellar artery |
| I63.342 | Cerebral infarction due to thrombosis of left cerebellar artery |
| I63.343 | Cerebral infarction due to thrombosis of bilateral cerebellar arteries |
| I63.349 | Cerebral infarction due to thrombosis of unspecified cerebellar artery |
| I63.39 | Cerebral infarction due to thrombosis of other cerebral artery |
| I63.8 | Other cerebral infarction |
| I63.9 | Cerebral infarction, unspecified |
| I67.2 | Cerebral atherosclerosis |
| I70 | Atherosclerosis |
| I70.0 | Atherosclerosis of aorta |
| I70.1 | Atherosclerosis of renal artery |
| I70.2 | Atherosclerosis of native arteries of the extremities |
| I70.20 | Unspecified atherosclerosis of native arteries of extremities |
| I70.201 | Unspecified atherosclerosis of native arteries of extremities, right leg |
| I70.202 | Unspecified atherosclerosis of native arteries of extremities, left leg |
| I70.203 | Unspecified atherosclerosis of native arteries of extremities, bilateral legs |
| I70.208 | Unspecified atherosclerosis of native arteries of extremities, other extremity |
| I70.209 | Unspecified atherosclerosis of native arteries of extremities, unspecified extremity |
| I70.21 | Atherosclerosis of native arteries of extremities with intermittent claudication |
| I70.211 | Atherosclerosis of native arteries of extremities with intermittent claudication, right leg |
| I70.212 | Atherosclerosis of native arteries of extremities with intermittent claudication, left leg |
| I70.213 | Atherosclerosis of native arteries of extremities with intermittent claudication, bilateral legs |
| I70.218 | Atherosclerosis of native arteries of extremities with intermittent claudication, other extremity |
| I70.219 | Atherosclerosis of native arteries of extremities with intermittent claudication, unspecified extremity |
| I70.22 | Atherosclerosis of native arteries of extremities with rest pain |
| I70.221 | Atherosclerosis of native arteries of extremities with rest pain, right leg |
| I70.222 | Atherosclerosis of native arteries of extremities with rest pain, left leg |
| I70.223 | Atherosclerosis of native arteries of extremities with rest pain, bilateral legs |
| I70.228 | Atherosclerosis of native arteries of extremities with rest pain, other extremity |
| I70.229 | Atherosclerosis of native arteries of extremities with rest pain, unspecified extremity |
| I70.23 | Atherosclerosis of native arteries of right leg with ulceration |
| I70.231 | Atherosclerosis of native arteries of right leg with ulceration of thigh |
| I70.232 | Atherosclerosis of native arteries of right leg with ulceration of calf |
| I70.233 | Atherosclerosis of native arteries of right leg with ulceration of ankle |
| I70.234 | Atherosclerosis of native arteries of right leg with ulceration of heel and midfoot |
| I70.235 | Atherosclerosis of native arteries of right leg with ulceration of other part of foot |
| I70.238 | Atherosclerosis of native arteries of right leg with ulceration of other part of lower leg |
| I70.239 | Atherosclerosis of native arteries of right leg with ulceration of unspecified site |
| I70.24 | Atherosclerosis of native arteries of left leg with ulceration |
| I70.241 | Atherosclerosis of native arteries of left leg with ulceration of thigh |
| I70.242 | Atherosclerosis of native arteries of left leg with ulceration of calf |
| I70.243 | Atherosclerosis of native arteries of left leg with ulceration of ankle |
| I70.244 | Atherosclerosis of native arteries of left leg with ulceration of heel and midfoot |
| I70.245 | Atherosclerosis of native arteries of left leg with ulceration of other part of foot |
| I70.248 | Atherosclerosis of native arteries of left leg with ulceration of other part of lower leg |
| I70.249 | Atherosclerosis of native arteries of left leg with ulceration of unspecified site |
| I70.25 | Atherosclerosis of native arteries of other extremities with ulceration |
| I70.26 | Atherosclerosis of native arteries of extremities with gangrene |
| I70.261 | Atherosclerosis of native arteries of extremities with gangrene, right leg |
| I70.262 | Atherosclerosis of native arteries of extremities with gangrene, left leg |
| I70.263 | Atherosclerosis of native arteries of extremities with gangrene, bilateral legs |
| I70.268 | Atherosclerosis of native arteries of extremities with gangrene, other extremity |
| I70.269 | Atherosclerosis of native arteries of extremities with gangrene, unspecified extremity |
| I70.29 | Other atherosclerosis of native arteries of extremities |
| I70.291 | Other atherosclerosis of native arteries of extremities, right leg |
| I70.292 | Other atherosclerosis of native arteries of extremities, left leg |
| I70.293 | Other atherosclerosis of native arteries of extremities, bilateral legs |
| I70.298 | Other atherosclerosis of native arteries of extremities, other extremity |
| I70.299 | Other atherosclerosis of native arteries of extremities, unspecified extremity |
| I70.3 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities |
| I70.30 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities |
| I70.301 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, right leg |
| I70.302 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, left leg |
| I70.303 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, bilateral legs |
| I70.308 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, other extremity |
| I70.309 | Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, unspecified extremity |
| I70.31 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication |
| I70.311 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.312 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.313 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.318 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.319 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.32 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain |
| I70.321 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, right leg |
| I70.322 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, left leg |
| I70.323 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, bilateral legs |
| I70.328 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, other extremity |
| I70.329 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, unspecified extremity |
| I70.33 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration |
| I70.331 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of thigh |
| I70.332 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of calf |
| I70.333 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of ankle |
| I70.334 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of heel and midfoot |
| I70.335 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of foot |
| I70.338 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of lower leg |
| I70.339 | Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of unspecified site |
| I70.34 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration |
| I70.341 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of thigh |
| I70.342 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of calf |
| I70.343 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of ankle |
| I70.344 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of heel and midfoot |
| I70.345 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of foot |
| I70.348 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of lower leg |
| I70.349 | Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of unspecified site |
| I70.35 | Atherosclerosis of unspecified type of bypass graft(s) of other extremity with ulceration |
| I70.36 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene |
| I70.361 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, right leg |
| I70.362 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, left leg |
| I70.363 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, bilateral legs |
| I70.368 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, other extremity |
| I70.369 | Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, unspecified extremity |
| I70.39 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities |
| I70.391 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, right leg |
| I70.392 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, left leg |
| I70.393 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, bilateral legs |
| I70.398 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, other extremity |
| I70.399 | Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, unspecified extremity |
| I70.4 | Atherosclerosis of autologous vein bypass graft(s) of the extremities |
| I70.40 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities |
| I70.401 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, right leg |
| I70.402 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, left leg |
| I70.403 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, bilateral legs |
| I70.408 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, other extremity |
| I70.409 | Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity |
| I70.41 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication |
| I70.411 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.412 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.413 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.418 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.419 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.42 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain |
| I70.421 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, right leg |
| I70.422 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, left leg |
| I70.423 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, bilateral legs |
| I70.428 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, other extremity |
| I70.429 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, unspecified extremity |
| I70.43 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration |
| I70.431 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of thigh |
| I70.432 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of calf |
| I70.433 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of ankle |
| I70.434 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of heel and midfoot |
| I70.435 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of foot |
| I70.438 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of lower leg |
| I70.439 | Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of unspecified site |
| I70.44 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration |
| I70.441 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of thigh |
| I70.442 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of calf |
| I70.443 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of ankle |
| I70.444 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of heel and midfoot |
| I70.445 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of foot |
| I70.448 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of lower leg |
| I70.449 | Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of unspecified site |
| I70.45 | Atherosclerosis of autologous vein bypass graft(s) of other extremity with ulceration |
| I70.46 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene |
| I70.461 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, right leg |
| I70.462 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, left leg |
| I70.463 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, bilateral legs |
| I70.468 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, other extremity |
| I70.469 | Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, unspecified extremity |
| I70.49 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities |
| I70.491 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities, right leg |
| I70.492 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities, left leg |
| I70.493 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities, bilateral legs |
| I70.498 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities, other extremity |
| I70.499 | Other atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity |
| I70.5 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities |
| I70.50 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities |
| I70.501 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg |
| I70.502 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg |
| I70.503 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs |
| I70.508 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity |
| I70.509 | Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity |
| I70.51 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities intermittent claudication |
| I70.511 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.512 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.513 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.518 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.519 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.52 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain |
| I70.521 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, right leg |
| I70.522 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, left leg |
| I70.523 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, bilateral legs |
| I70.528 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, other extremity |
| I70.529 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, unspecified extremity |
| I70.53 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration |
| I70.531 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of thigh |
| I70.532 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of calf |
| I70.533 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of ankle |
| I70.534 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of heel and midfoot |
| I70.535 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of foot |
| I70.538 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of lower leg |
| I70.539 | Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of unspecified site |
| I70.54 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration |
| I70.541 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of thigh |
| I70.542 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of calf |
| I70.543 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of ankle |
| I70.544 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of heel and midfoot |
| I70.545 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of foot |
| I70.548 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of lower leg |
| I70.549 | Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of unspecified site |
| I70.55 | Atherosclerosis of nonautologous biological bypass graft(s) of other extremity with ulceration |
| I70.56 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene |
| I70.561 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, right leg |
| I70.562 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, left leg |
| I70.563 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, bilateral legs |
| I70.568 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, other extremity |
| I70.569 | Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, unspecified extremity |
| I70.59 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities |
| I70.591 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg |
| I70.592 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg |
| I70.593 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs |
| I70.598 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity |
| I70.599 | Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity |
| I70.6 | Atherosclerosis of nonbiological bypass graft(s) of the extremities |
| I70.60 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities |
| I70.601 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg |
| I70.602 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg |
| I70.603 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs |
| I70.608 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity |
| I70.609 | Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity |
| I70.61 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication |
| I70.611 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.612 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.613 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.618 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.619 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.62 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain |
| I70.621 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, right leg |
| I70.622 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, left leg |
| I70.623 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, bilateral legs |
| I70.628 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, other extremity |
| I70.629 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, unspecified extremity |
| I70.63 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration |
| I70.631 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of thigh |
| I70.632 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of calf |
| I70.633 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of ankle |
| I70.634 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of heel and midfoot |
| I70.635 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of foot |
| I70.638 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of lower leg |
| I70.639 | Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of unspecified site |
| I70.64 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration |
| I70.641 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of thigh |
| I70.642 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of calf |
| I70.643 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of ankle |
| I70.644 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of heel and midfoot |
| I70.645 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of foot |
| I70.648 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of lower leg |
| I70.649 | Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of unspecified site |
| I70.65 | Atherosclerosis of nonbiological bypass graft(s) of other extremity with ulceration |
| I70.66 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene |
| I70.661 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, right leg |
| I70.662 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, left leg |
| I70.663 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, bilateral legs |
| I70.668 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, other extremity |
| I70.669 | Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, unspecified extremity |
| I70.69 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities |
| I70.691 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg |
| I70.692 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg |
| I70.693 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs |
| I70.698 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity |
| I70.699 | Other atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity |
| I70.7 | Atherosclerosis of other type of bypass graft(s) of the extremities |
| I70.70 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities |
| I70.701 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, right leg |
| I70.702 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, left leg |
| I70.703 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs |
| I70.708 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, other extremity |
| I70.709 | Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity |
| I70.71 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication |
| I70.711 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, right leg |
| I70.712 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, left leg |
| I70.713 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs |
| I70.718 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, other extremity |
| I70.719 | Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity |
| I70.72 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain |
| I70.721 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, right leg |
| I70.722 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, left leg |
| I70.723 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, bilateral legs |
| I70.728 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, other extremity |
| I70.729 | Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, unspecified extremity |
| I70.73 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration |
| I70.731 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of thigh |
| I70.732 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of calf |
| I70.733 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of ankle |
| I70.734 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of heel and midfoot |
| I70.735 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of foot |
| I70.738 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of lower leg |
| I70.739 | Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of unspecified site |
| I70.74 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration |
| I70.741 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of thigh |
| I70.742 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of calf |
| I70.743 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of ankle |
| I70.744 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of heel and midfoot |
| I70.745 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of foot |
| I70.748 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of lower leg |
| I70.749 | Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of unspecified site |
| I70.75 | Atherosclerosis of other type of bypass graft(s) of other extremity with ulceration |
| I70.76 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene |
| I70.761 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, right leg |
| I70.762 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, left leg |
| I70.763 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, bilateral legs |
| I70.768 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, other extremity |
| I70.769 | Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, unspecified extremity |
| I70.79 | Other atherosclerosis of other type of bypass graft(s) of the extremities |
| I70.791 | Other atherosclerosis of other type of bypass graft(s) of the extremities, right leg |
| I70.792 | Other atherosclerosis of other type of bypass graft(s) of the extremities, left leg |
| I70.793 | Other atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs |
| I70.798 | Other atherosclerosis of other type of bypass graft(s) of the extremities, other extremity |
| I70.799 | Other atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity |
| I70.8 | Atherosclerosis of other arteries |
| I70.9 | Other and unspecified atherosclerosis |
| I70.90 | Unspecified atherosclerosis |
| I70.91 | Generalized atherosclerosis |
| I70.92 | Chronic total occlusion of artery of the extremities |
| Z95.1 | Presence of aortocoronary bypass graft |
| Z95.820 | Peripheral vascular angioplasty status with implants and grafts |
| Z98.61 | Coronary angioplasty status |
| Z98.62 | Peripheral vascular angioplasty status |
| Heterozygous familial hypercholesterolemia | |
| E78.01 | Familial hypercholesterolemia |
| Hypercholesterolemia | |
| E78.0 | Pure hypercholesterolemia |
| E78.00 | Pure hypercholesterolemia, unspecified |
| E78.01 | Familial hypercholesterolemia |
| Hyperlipidemia | |
| E78.2 | Mixed hyperlipidemia |
| E78.4 | Other hyperlipidemia |
| E78.49 | Other hyperlipidemia |
| E78.5 | Hyperlipidemia, unspecified |
| Mixed hyperlipidemia | |
| E78.2 | Mixed hyperlipidemia |
| Treatment to slow progression of coronary artery disease | |
| I25 | Chronic ischemic heart disease |
| I25.1 | Atherosclerotic heart disease of native coronary artery |
| I25.10 | Atherosclerotic heart disease of native coronary artery without angina pectoris |
| I25.11 | Atherosclerotic heart disease of native coronary artery with angina pectoris |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.111 | Atherosclerotic heart disease of native coronary artery with angina pectoris with documented spasm |
| I25.112 | Atherosclerotic heart disease of native coronary artery with refractory angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.7 | Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris |
| I25.70 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.701 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasm |
| I25.702 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with refractory angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.71 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.711 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.712 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with refractory angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.72 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.721 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.722 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with refractory angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.73 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.731 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.732 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with refractory angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.75 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.751 | Atherosclerosis of native coronary artery of transplanted heart with angina pectoris with documented spasm |
| I25.752 | Atherosclerosis of native coronary artery of transplanted heart with refractory angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.76 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.761 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris with documented spasm |
| I25.762 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with refractory angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.79 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| I25.791 | Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris with documented spasm |
| I25.792 | Atherosclerosis of other coronary artery bypass graft(s) with refractory angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.8 | Other forms of chronic ischemic heart disease |
| I25.81 | Atherosclerosis of other coronary vessels without angina pectoris |
| I25.810 | Atherosclerosis of coronary artery bypass graft(s) without angina pectoris |
| I25.811 | Atherosclerosis of native coronary artery of transplanted heart without angina pectoris |
| I25.812 | Atherosclerosis of bypass graft of coronary artery of transplanted heart without angina pectoris |
| I25.82 | Chronic total occlusion of coronary artery |
| I25.83 | Coronary atherosclerosis due to lipid rich plaque |
| I25.84 | Coronary atherosclerosis due to calcified coronary lesion |
| I25.85 | Chronic coronary microvascular dysfunction |
| I25.89 | Other forms of chronic ischemic heart disease |
| I25.9 | Chronic ischemic heart disease, unspecified |
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