CEFDINIR (cefdinir)

There are 0 contraindications.

There are 1 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Clostridioides difficile infection

There are 1 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Severe renal impairment

There are 17 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare

Acquired hemolytic anemia Anaphylaxis Aplastic anemia secondary to drugs Clostridioides difficile infection Erythema multiforme Hepatitis Increased alanine transaminase Increased aspartate transaminase Kidney disease with reduction in glomerular filtration rate (GFr) Leukopenia Neutropenic disorder Pancytopenia Seizure disorder Serum sickness Stevens-johnson syndrome Toxic epidermal necrolysis Vaginal discharge

There are 22 less severe adverse reactions.

More Frequent	Less Frequent
Cutaneous candidiasis Diarrhea Disorder of the digestive system Headache disorder Nausea Vaginitis Vomiting Vulvovaginal candidiasis

Rare/Very Rare
Anorexia Conjunctivitis Constipation Dizziness Drowsy General weakness Hearing disorder Insomnia Pruritus of skin Skin rash Xerostomia

Reproduction studies in rats or rabbits using oral cefdinir in dosages 70 or 0.7 times, respectively, the usual human dosage (based on mg/kg daily) have not revealed evidence of teratogenicity. There are no adequate and controlled studies using cefdinir in pregnant women or during labor and delivery, and the drug should be used during pregnancy only when clearly needed.

Drug/Drug Class	Severity	Precaution Description	Pregnancy Category Description
Cefdinir	B		Animal studies have failed to demonstrate a risk to the fetus but there are no well-controlled studies in pregnant women; or animal reproduction studies have shown an adverse effect (other than decrease in fertility), but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus during the first trimester of pregnancy (and there is no evidence of a risk in later trimesters).

Cefdinir was not detected in human milk following a single 600-mg oral dose of the drug.

Precaution Exists
Precaution exists. (No data or inconclusive human data.) Use of this drug by breast feeding mothers should be evaluated carefully.

Drug Name	Excretion Potential	Effect on Infant	Notes
Cefdinir	Unknown. It is unknown whether the drug is excreted in human breast milk.	It is not known whether this drug has an adverse effect on the nursing infant. (No data or inconclusive human data)	Not excreted in breastmilk, unknown effects on infant.

No enhanced Geriatric Use information available for this drug.