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AMRIX (CYCLOBENZAPRINE HCL)
- Muscle spasm
- Cyclobenzaprine Er Capsule,extended Release 24 Hr
- Amrix Capsule,extended Release
- Amrix 24 Hr Cap
- By Indication
cyclobenzaprine ER 15 mg capsule,extended release 24 hr
- 1 capsule (15 mg) by oral route once daily
cyclobenzaprine ER 30 mg capsule,extended release 24 hr
- 1 capsule (30 mg) by oral route once daily
ER 15 mg capsule,extended release 24 hr
- 1 capsule (15 mg) by oral route once daily
ER 30 mg capsule,extended release 24 hr
- 1 capsule (30 mg) by oral route once daily
15 mg capsule,extended release
- 1 capsule (15 mg) by oral route once daily
30 mg capsule,extended release
- 1 capsule (30 mg) by oral route once daily
15 mg capsule,extended release
- 1 capsule (15 mg) by oral route once daily
30 mg capsule,extended release
- 1 capsule (30 mg) by oral route once daily
Muscle spasm
- 1 capsule (15 mg) by oral route once daily
- 1 capsule (15 mg) by oral route once daily ; sprinkle contents on tablespoon of applesauce and consume immediately without chewing
- 2 capsules (30 mg) by oral route once daily
- 2 capsules (30 mg) by oral route once daily ; sprinkle contents on tablespoon of applesauce and consume immediately without chewing
- 1 capsule (30 mg) by oral route once daily ; sprinkle contents on tablespoon of applesauce and consume immediately without chewing
- 1 capsule (30 mg) by oral route once daily
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Orap
- Parnate
- phenelzine
- pimozide
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Conzip
- Nucynta
- Nucynta Er
- sodium oxybate
- Synapryn
- tapentadol
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
- Xyrem
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Advair Diskus
- Advair Hfa
- albuterol sulfate
- Anoro Ellipta
- Arcapta Neohaler
- arformoterol
- Breo Ellipta
- Bronchial Mist
- Bronchial Mist Refill
- Brovana
- budesonide-formoterol
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- cimetidine
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- Combivent Respimat
- Dulera
- Duoneb
- Duraclon (pf)
- epinephrine
- epinephrine base (refill)
- fluticasone-salmeterol
- fluticasone-vilanterol
- Foradil Aerolizer
- formoterol fumarate
- fosamprenavir
- Heartburn Relief
- indacaterol
- ipratropium-albuterol
- Kapvay
- Lamisil
- levalbuterol HCl
- levalbuterol tartrate
- Lexiva
- mometasone-formoterol
- Perforomist
- Proair Hfa
- Proventil Hfa
- salmeterol
- Serevent Diskus
- Symbicort
- Tagamet Hb
- terbinafine
- umeclidinium-vilanterol
- Ventolin Hfa
- Xopenex
- Xopenex Concentrate
- Xopenex Hfa
- 30 day risk period post-myocardial infarction
- Cardiac arrhythmia
- Chronic heart failure
- Heart block
- Hyperthyroidism
Contraindicated
- Severe hepatic disease
- Sinus tachycardia
Severe
Moderate
- Glaucoma
- Open angle glaucoma
- Urinary retention
AMRIX (CYCLOBENZAPRINE HCL)
- Muscle spasm
- None
- Dizziness
- Drowsy
- Dyspepsia
- Fatigue
- Nausea
- Xerostomia
More Frequent
Severe
Less Severe
- None
- Blurred vision
- Dysgeusia
- Headache disorder
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal electroencephalogram
- Abnormal hepatic function tests
- Acute confusion
- Acute myocardial infarction
- Anaphylaxis
- Angioedema
- Ataxia
- Bronchospastic pulmonary disease
- Cardiac arrhythmia
- Cerebrovascular accident
- Cholestasis
- CNS toxicity
- Depression
- DRESS syndrome
- Drug-induced psychosis
- Dyspnea
- Extrapyramidal disease
- Hallucinations
- Heart block
- Hepatitis
- Hypertension
- Jaundice
- Neuroleptic malignant syndrome
- Paranoid disorder
- Pruritus of skin
- Seizure disorder
- Serotonin syndrome
- SIADH syndrome
- Syncope
- Tachycardia
- Urinary retention
- Urticaria
Less Severe
- Acne vulgaris
- Acute abdominal pain
- Agitation
- Allergic dermatitis
- Anorexia
- Bell's palsy
- Chest pain
- Constipation
- Diarrhea
- Disturbance of attention
- Dysarthria
- Dysuria
- Edema
- Flatulence
- Galactorrhea not associated with childbirth
- Gastrointestinal irritation
- Gynecomastia
- Hyperhidrosis
- Hypotension
- Increased urinary frequency
- Insomnia
- Libido changes
- Loss of taste
- Malaise
- Muscle weakness
- Nervousness
- Palpitations
- Paresthesia
- Parotitis
- Skin rash
- Tinnitus
- Tremor
- Twitching
- Vasodilation of blood vessels
- Vertigo
- Vomiting
Contraindicated
None
Severe Precaution
Cyclobenzaprine
Safety and efficacy not established in pediatrics less than 15 years.
- 1 Day – 15 Years
- Safety and efficacy not established in pediatrics less than 15 years.
Management or Monitoring Precaution
None
Cyclobenzaprine Hydrochloride
- Severity Level:
2
- Additional Notes: Insufficient human data available; assess risk/benefit
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Cyclobenzaprine
Exercise caution in breastfeeding. related tricyclics are excreted.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Exercise caution in breastfeeding. related tricyclics are excreted. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
Cyclobenzaprine (ext. Release)
General-Long acting product not recommended. Half life increased >50% in elderly. Neuro/Psych-Anticholinergic effects may cause significant sedation, confusion, worsen cognitive impairment and increase fall risk. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause. Cardiovascular-Risk of tachycardia and arrhythmia.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Precaution Exists
None
No Known Risk
None
- None
| Muscle spasm | |
| M62.83 | Muscle spasm |
| M62.830 | Muscle spasm of back |
| M62.831 | Muscle spasm of calf |
| M62.838 | Other muscle spasm |
| R25.2 | Cramp and spasm |
| 0-9 | A-Z |
|---|---|
| M62.83 | Muscle spasm |
| M62.830 | Muscle spasm of back |
| M62.831 | Muscle spasm of calf |
| M62.838 | Other muscle spasm |
| R25.2 | Cramp and spasm |
Formulary Reference Tool