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PROGLYCEM (DIAZOXIDE)
- Hyperinsulinism
- Insulinoma
- Nesidioblastosis
50 mg/mL oral suspension
- 1.5 mg/kg by oral route every 12 hours
Hyperinsulinism
- 1.5 mg/kg by oral route every 12 hours
- 1 mg/kg by oral route every 8 hours
- 4 mg/kg by oral route every 12 hours
- 2.7 mg/kg by oral route every 8 hours
Insulinoma
- 1.5 mg/kg by oral route every 12 hours
- 1 mg/kg by oral route every 8 hours
- 4 mg/kg by oral route every 12 hours
- 2.7 mg/kg by oral route every 8 hours
- None
Contraindicated
- None
Severe
Moderate
- Accuretic
- Aldactazide
- aliskiren-amlodipin-hcthiazide
- aliskiren-hydrochlorothiazide
- Amaryl
- amiloride-hydrochlorothiazide
- amlodipine-valsartan-hcthiazid
- Amturnide
- Atacand Hct
- atenolol-chlorthalidone
- Avalide
- azilsartan med-chlorthalidone
- benazepril-hydrochlorothiazide
- Benicar Hct
- bisoprolol-hydrochlorothiazide
- candesartan-hydrochlorothiazid
- captopril-hydrochlorothiazide
- Cerebyx
- chlorothiazide
- chlorothiazide sodium
- chlorthalidone
- clonidine-chlorthalidone
- Clorpres
- Corzide
- Diabeta
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Diovan Hct
- Diuril
- Diuril Iv
- Duetact
- Dutoprol
- Dyazide
- Edarbyclor
- enalapril-hydrochlorothiazide
- eprosartan-hydrochlorothiazide
- ethotoin
- Exforge Hct
- fosinopril-hydrochlorothiazide
- fosphenytoin
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- hydrochlorothiazide
- Hyzaar
- indapamide
- irbesartan-hydrochlorothiazide
- lisinopril-hydrochlorothiazide
- Lopressor Hct
- losartan-hydrochlorothiazide
- Maxzide
- Maxzide-25Mg
- methyclothiazide
- methyldopa-hydrochlorothiazide
- metolazone
- metoprolol su-hydrochlorothiaz
- metoprolol ta-hydrochlorothiaz
- Micardis Hct
- Microzide
- moexipril-hydrochlorothiazide
- nadolol-bendroflumethiazide
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Peganone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pioglitazone-glimepiride
- propranolol-hydrochlorothiazid
- quinapril-hydrochlorothiazide
- spironolacton-hydrochlorothiaz
- Tekturna Hct
- telmisartan-hydrochlorothiazid
- Tenoretic 100
- Tenoretic 50
- Teveten Hct
- tolazamide
- tolbutamide
- triamterene-hydrochlorothiazid
- Tribenzor
- Uniretic
- valsartan-hydrochlorothiazide
- Vaseretic
- Zaroxolyn
- Zestoretic
- Ziac
- None
Contraindicated
- Chronic heart failure
- Ketoacidosis
- Uremia
Severe
Moderate
- Edema
- Gout
- Hyperkalemia
- Hyperuricemia
- Hypokalemia
- Kidney disease with reduction in GFR
PROGLYCEM (DIAZOXIDE)
- Hyperinsulinism
- Insulinoma
- Nesidioblastosis
- Body fluid retention
- Chronic heart failure
- Hypernatremia
- Worsening of chronic heart failure
- Diarrhea
- Hirsutism
- Hyperuricemia
- Palpitations
More Frequent
Severe
Less Severe
- Hypotension
- Ileus
- Tachycardia
- Abdominal pain with cramps
- Anorexia
- Dizziness
- Dysgeusia
- Edema
- General weakness
- Hyperglycemia
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Cataracts
- Diabetic hyperosmolar coma
- Diabetic ketoacidosis
- Extrapyramidal disease
- Extravasation injury
- Gout
- Hematuria
- Hemorrhage
- Kidney disease with reduction in GFR
- Nephrotic syndrome
- Skin rash
- Subconjunctival hemorrhage
- Thrombocytopenic disorder
- Urticaria
- Visual changes
Less Severe
- Anemia
- Blurred vision
- Chest pain
- Cutaneous candidiasis
- Diplopia
- Drug fever
- Eosinophilia
- Eye tearing
- Galactorrhea not associated with childbirth
- Headache disorder
- Hypesthesia
- Insomnia
- Lymphadenopathy
- Malaise
- Neutropenic disorder
- Oliguria
- Paresthesia
- Polyneuropathy
- Proteinuria
- Pruritus of skin
- Scotomata
- Symptoms of anxiety
Contraindicated
None
Severe Precaution
Diazoxide (Suspension)
Cases of pulmonary hypertension reported in neonates and infants with oral suspension. Monitor for signs and symptoms of respiratory distress.
- 1 Day – 13 Years
- Cases of pulmonary hypertension reported in neonates and infants with oral suspension. Monitor for signs and symptoms of respiratory distress.
Management or Monitoring Precaution
None
Diazoxide (oral Systemic)
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Diazoxide
Insuff. data avail. molecular wt low enough for possible breastmilk excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff. data avail. molecular wt low enough for possible breastmilk excretion |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Diazoxide
Renal- Consider reduced dose with impaired renal function. Cardiovascular-Fluid retention may lead precipitate heart failure.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- None
| Hyperinsulinism | |
| E16.1 | Other hypoglycemia |
| Insulinoma | |
| C25.4 | Malignant neoplasm of endocrine pancreas |
| D13.7 | Benign neoplasm of endocrine pancreas |
| Nesidioblastosis | |
| E16.9 | Disorder of pancreatic internal secretion, unspecified |
| 0-9 | A-Z |
|---|---|
| C25.4 | Malignant neoplasm of endocrine pancreas |
| D13.7 | Benign neoplasm of endocrine pancreas |
| E16.1 | Other hypoglycemia |
| E16.9 | Disorder of pancreatic internal secretion, unspecified |
Formulary Reference Tool