EDARBYCLOR (AZILSARTAN MEDOXOMIL/CHLORTHALIDONE)
- Hypertension
40 mg-12.5 mg tablet
- 1 tablet by oral route once daily
40 mg-25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Amturnide
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- lithium carbonate
- lithium citrate
- Lithobid
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aldactazide
- Aldactone
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer Gold
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- amiloride
- amiloride-hydrochlorothiazide
- Anaprox
- Anaprox Ds
- Angeliq
- Ansaid
- Apidra
- Apidra Solostar
- Arthrotec 50
- Bactrim
- Bactrim Ds
- Beyaz
- bumetanide
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Ceralyte-70
- Ceraors 75
- Cerasport
- Cerasport Ex1
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colestid
- Colestid Flavored
- colestipol
- Cytra K Crystals
- Cytra-3
- Cytra-k
- Daypro
- Demadex
- Diabeta
- diazoxide
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Digox
- digoxin
- DM-GG-potassium citrate
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Duetact
- Duexis
- Dyazide
- Dyrenium
- Ec-naprosyn
- Effer-k
- eplerenone
- ethacrynate sodium
- etodolac
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- furosemide
- Gianvi (28)
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydrocodone-ibuprofen
- Hyperlyte Cr
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Inspra
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- K-effervescent
- K-phos No 2
- K-phos Original
- K-phos-neutral
- K-tab
- Kaochlor
- ketoprofen
- ketorolac
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Klor-con/ef
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levemir
- Levemir Flexpen
- Loryna (28)
- Maxzide
- Maxzide-25Mg
- Medi-lyte
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- miglitol
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Nano Vm T/f
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Neoprofen (ibuprofen Lysn)(pf)
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Nutrilyte Ii
- Ocella
- oxaprozin
- Pedialyte
- Pediatric Electrolyte
- pediatric multivit #18-iron-FA
- PEG 3350-bowel 2,two part prep
- Pennsaid
- Phos-nak
- Phospha 250 Neutral
- pioglitazone-glimepiride
- piroxicam
- Ponstel
- pot & sod citrate-citric acid
- potassium
- potassium & sodium phosphates
- potassium bicarb & chloride
- potassium bicarb-citric acid
- potassium chlorid-D5-0.45%NaCl
- potassium chloride
- potassium chloride in 0.9%NaCl
- potassium chloride in D5W
- potassium chloride in LR-D5
- potassium chloride-0.45 % NaCl
- potassium chloride-D5-0.2%NaCl
- potassium chloride-D5-0.3%NaCl
- potassium chloride-D5-0.9%NaCl
- potassium citrate
- potassium citrate-citric acid
- potassium Cl-calcium phos-mag
- potassium gluconate
- potassium phosphate dibasic
- potassium phosphate, monobasic
- potassium&sodium monobas phos
- Precose
- Prevalite
- Primsol
- Proglycem
- Provil
- pseudoephedrine-ibuprofen
- Questran
- Questran Light
- Reprexain
- Safyral
- Sinus & Cold-d
- sod & pot chlorid-sod cit-rice
- sod phos,di & mono-K phos mono
- sodium & potassium bicarbonate
- sodium Cl-potassium chloride
- Sodium Edecrin
- sodium-K+-mag-Ca-chlor-acetate
- sodium-potas-chloride-dextrose
- Solaraze
- Sorbutuss
- spironolacton-hydrochlorothiaz
- spironolactone
- Sprix
- Starlix
- Suclear
- sulfamethoxazole-trimethoprim
- Sulfatrim
- sulindac
- Syeda
- Taron-crystals
- Theralith Xr
- Thermotabs
- tolazamide
- tolbutamide
- tolmetin
- torsemide
- Tpn Electrolytes
- Tpn Electrolytes Ii
- triamterene
- triamterene-hydrochlorothiazid
- Tricitrates
- trimethoprim
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- Vestura (28)
- Vicoprofen
- Vimovo
- vit B6-mag cit & ox-potass cit
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Yasmin (28)
- Yaz 28
- Zarah
- Zipsor
- Zorvolex
- Anuria
- Lactating mother
- Pregnancy
Contraindicated
- Hyponatremia
- Hypotension
- Hypovolemia
- Kidney disease with likely reduction in GFR
- Kidney disease with reduction in GFR
- Oliguria
- Pregnancy
Severe
Moderate
- Gout
- Hypercalcemia
- Hypercholesterolemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Renal artery stenosis
- Sympathectomy
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
EDARBYCLOR (AZILSARTAN MEDOXOMIL/CHLORTHALIDONE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Diarrhea
More Frequent
Severe
Less Severe
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Diarrhea
- Dizziness
- Fatigue
- Hypotension
- Nausea
- Orthostatic hypotension
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aplastic anemia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperkalemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Kidney disease with reduction in GFR
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Purpura
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Cough
- Erectile dysfunction
- Fatigue
- Fever
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Muscle spasm
- Nausea
- Nervousness
- Paresthesia
- Pruritus of skin
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Azilsartan
Safety and efficacy not established.
No safety and efficacy data in children.
- 1 Day – 18 Years
- Safety and efficacy not established.
- 1 Day – 364 Days
- Safety and efficacy not established.
Chlorthalidone
Safety and efficacy not established.
No safety and efficacy data in children.
- 1 Day – 18 Years
- No safety and efficacy data in children.
- 1 Day – 364 Days
- No safety and efficacy data in children.
Azilsartan
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Chlorthalidone
- Severity Level:
D
- Additional Notes: Avoid as first line treatment for hypertension during pregnancy
Contraindicated
Chlorthalidone
Mfg does not rec, minimal amnts may be excreted; may suppress lactation
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Mfg does not rec, minimal amnts may be excreted; may suppress lactation |
Precaution Exists
Azilsartan
Insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Chlorthalidone
General-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Cardiovascular-Elderly are more sensitive to blood pressure changes. Renal-Less effective in severe renal impairment. Endocrine-May exacerbate SIADH.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.
Hypertension | |
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
0-9 | A-Z |
---|---|
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |