PRESTALIA (perindopril arginine/amlodipine besylate)

Moderate

• Added Strength Headache Relief

• Added Strength Pain Reliever

• Alka-seltzer

• Alka-seltzer Extra Strength

• Alka-seltzer Original

• Alka-seltzer Plus C/c(pe,dm)

• Alka-seltzer Plus Cold (pe)

• Alka-seltzer Plus Day-night

• Alka-seltzer Plus Night

• Alka-seltzer Pm

• Anacin

• Anacin Maximum Strength

• Analgesic

• Angeliq

• Antacid & Pain Relief

• ASA-acetaminophen-caff-buffers

• ASA-acetaminophen-salicyl-caff

• Ascomp With Codeine

• Aspir-trin

• aspirin

• aspirin, buffered

• aspirin-acetaminophen-caffeine

• aspirin-caffeine

• aspirin-diphenhydramine

• aspirin-diphenhydramine citrat

• aspirin-sod bicarb-citric acid

• Astagraf Xl

• Azasan

• azathioprine

• azathioprine sodium

• Back & Body Pain Reliever

• Bactrim

• Bactrim Ds

• Bayer Advanced

• Bayer Aspirin

• Bayer Aspirin (with Caffeine)

• Bayer Back & Body

• Bayer Plus Extra Strength

• Bayer Pm

• Bc

• Bc Arthritis

• Beyaz

• boceprevir

• Buffered Aspirin

• Bufferin

• bumetanide

• Butalbital Compound W/codeine

• Butalbital Compound-codeine

• butalbital-aspirin-caffeine

• carisoprodol-ASA-codeine

• carisoprodol-aspirin

• chlorphen-phenyleph-DM-aspirin

• chlorphenir-phenylephrn-aspirn

• codeine-butalbital-ASA-caff

• Cold Relief

• Cold Relief Plus

• cyclosporine

• cyclosporine modified

• Demadex

• dihydrocodeine-aspirin-caff

• doxylamine-phenylep-DM-aspirin

• drospirenone-e.estradiol-lm.FA

• drospirenone-estradiol

• drospirenone-ethinyl estradiol

• E.c. Prin

• Ecotrin

• Efferves Pain Relief Antacid

• Effervescent Antacid

• Effervescent Pain Relief

• Effervescent Pain Reliever

• Endodan

• ethacrynate sodium

• Excedrin Extra Strength

• Excedrin Migraine

• Extra Strength Bayer

• Fiorinal

• Fiorinal-codeine #3

• furosemide

• Gengraf

• Gianvi (28)

• Goody's Extra Strength

• Goody's Migraine Relief

• Headache Formula

• Headache Formula Added Str

• Headache Relief

• Hecoria

• Imuran

• Incivek

• isoniazid-rifamp-pyrazinamide

• Juxtapid

• ketoconazole

• Lasix

• Levacet

• Lite Coat Aspirin

• lomitapide

• Loryna (28)

• Medi-seltzer

• mercaptopurine

• Migraine Formula

• Migraine Pain Reliever

• Migraine Relief

• Mycobutin

• Neoral

• niacin-simvastatin

• Ocella

• Orphenadrine Compound Forte

• Orphenadrine Compound-ds

• orphenadrine-ASA-caffeine

• oxycodone-aspirin

• Pain Relief

• Pain Relief Extra Strength

• Pain Reliever

• Pain Reliever Extra Strength

• Pain Reliever Plus

• Pain-off

• Pamprin Max

• PE-DM-ASA/doxyla-PE-DM-ASA

• Percodan

• Priftin

• Primsol

• Prograf

• Purinethol

• rifabutin

• Rifadin

• Rifamate

• rifampin

• rifampin-isoniazid

• rifapentine

• Rifater

• Safyral

• Sandimmune

• Simcor

• simvastatin

• Sodium Edecrin

• sulfamethoxazole-trimethoprim

• Sulfatrim

• Super Pain Relief

• Syeda

• Synalgos-dc

• tacrolimus

• telaprevir

• torsemide

• Tri-buffered Aspirin

• trimethoprim

• Vanquish

• Vestura (28)

• Victrelis

• Vytorin 10-10

• Vytorin 10-20

• Yasmin (28)

• Yaz 28

• Zarah

• Zocor

Moderate

• Bone marrow depression

• Cerebrovascular insufficiency

• Disease of liver

• Kidney disease with reduction in GFR

• Renal artery stenosis

Amlodipine

• Severity Level:

  2

• Additional Notes: Uncontrolled htn can result in increased maternal/fetal morbidity and mortality

Perindopril

• Severity Level:

  1

• Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Amlodipine

Insufficient data avail; consider maternal treatment benefit vs infant risk

Insufficient human data available, drug excreted in rat studies

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Insufficient data avail; consider maternal treatment benefit vs infant risk

Perindopril

Insufficient data avail; consider maternal treatment benefit vs infant risk

Insufficient human data available, drug excreted in rat studies

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Insufficient human data available, drug excreted in rat studies

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Amlodipine

General-Not recommended as first line therapy in the elderly. Cardiovascular-Start at 2.5 mg/day and slowly titrate upward. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	Y	Y	N	N	N

BEERS: N     HEDIS: N     STOPP: Y

No Known Risk

None

0-9	A-Z
I10	Essential (primary) hypertension
I11	Hypertensive heart disease
I11.0	Hypertensive heart disease with heart failure
I11.9	Hypertensive heart disease without heart failure
I12	Hypertensive chronic kidney disease
I12.0	Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13	Hypertensive heart and chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.1	Hypertensive heart and chronic kidney disease without heart failure
I13.10	Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
I13.2	Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease
I15.1	Hypertension secondary to other renal disorders