HERBIOMED ALLERGY COLD-SINUS (diphenhydramine HCl/phenylephrine HCl/acetaminophen)
- inflammation of the nose due to an allergy
- allergic conjunctivitis
- flu-like symptoms
- runny nose
- sinus headache
- stuffy nose
- Robitussin Cold-flu Night (pe) Oral Liquid
- Mucinex Sinus-max Nite Congestion-cough Oral Liquid
- Mucinex Fast-max Nite Cold-flu Oral Liquid
- Herbiomed Allergy Cold-sinus Night Time Oral Liquid
- Cold And Flu Relief (diphen-pe) Oral Liquid
- Child Mucinex M-s Cold Night Oral Liquid
- Child Delsym Cough-cold Oral Liquid
- Child Delsym Cough+cold Oral Liquid
12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
ion-Cough 12.5-5-325 mg/10 mL oral liq
- Dosage information is not available
12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
Night 12.5 mg-5 mg-325 mg/10 mL oral liq
- Dosage information is not available
Cold and Flu Relief (diphen-pe) 12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
Child Delsym Cough-Cold 12.5 mg-5 mg-325 mg/10 mL oral liquid
- Dosage information is not available
- isocarboxazid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- tranylcypromine
Contraindicated
- Azilect
- bromocriptine
- cabergoline
- Cafergot
- Compound 347
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- enflurane
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Forane
- isoflurane
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- linezolid
- Medi-lyte
- methylergonovine
- Migergot
- Migranal
- Parlodel
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- rasagiline
- selegiline HCl
- sevoflurane
- sodium Cl-potassium chloride
- Sojourn
- Terrell
- Thermotabs
- Ultane
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- Zelapar
- Zyvox
Severe
Moderate
- Coumadin
- isoniazid
- isoniazid-rifamp-pyrazinamide
- Jantoven
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Rifamate
- rifampin-isoniazid
- Rifater
- Soltamox
- tamoxifen
- warfarin
- Acetaminophen overdose
- Acute hepatic failure
- Acute hepatitis C
- Severe uncontrolled hypertension
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Coronary artery disease
- Disease of liver
- Hypertension
- Hyperthyroidism
- Protein-calorie malnutrition
- Shock
- Stenosing peptic ulcer
- Urinary retention
Severe
Moderate
- Chronic heart failure
- Hypertension
- Hyperthyroidism
- Ocular hypertension
HERBIOMED ALLERGY COLD-SINUS (diphenhydramine HCl/phenylephrine HCl/acetaminophen)
- inflammation of the nose due to an allergy
- allergic conjunctivitis
- flu-like symptoms
- runny nose
- sinus headache
- stuffy nose
- None
- Dizziness
- Drowsy
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Acute hepatic failure
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Blood dyscrasias
- Cardiac arrhythmia
- Dizziness
- Drug-induced hepatitis
- Extrasystoles
- Hallucinations
- Headache disorder
- Hemolytic anemia
- Hyperhidrosis
- Hypersensitivity drug reaction
- Hypotension
- Insomnia
- Laryngeal edema
- Leukopenia
- Maculopapular rash
- Nervousness
- Neutropenic disorder
- Pallor
- Seizure disorder
- Stevens-johnson syndrome
- Tachycardia
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Tremor
Less Severe
- Abdominal distension
- Acute abdominal pain
- Acute confusion
- Anorexia
- Ataxia
- Blurred vision
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dry nose
- Dry throat
- Dyspnea
- Dysuria
- Erythema
- Euphoria
- Excitement
- Fatigue
- Headache disorder
- Hyperhidrosis
- Increased urinary frequency
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Medication overuse headache
- Migraine
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Vomiting
- Wheezing
- Xerostomia
Contraindicated
Diphenhydramine (Cough-Cold)
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 30 Days – 6 Years
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
- 1 Day – 29 Days
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
- 1 Day – 6 Years
- 1 Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
Diphenhydramine (Systemic)
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 30 Days – 6 Years
- 1 Possible risk of CNS excitation, convulsions in newborns.
- 1 Day – 29 Days
- 1 Possible risk of CNS excitation, convulsions in newborns.
- 1 Day – 6 Years
- 1 Possible risk of CNS excitation, convulsions in newborns.
Phenylephrine (oral)
Do not use unless as directed by clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation; risk of respiratory depression.
Possible risk of CNS excitation, convulsions in newborns.
Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 30 Days – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 29 Days
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
- 1 Day – 6 Years
- 1 Risk of CNS excitation. Do not use age <6 years without clinician consult.
Severe Precaution
None
Management or Monitoring Precaution
Acetaminophen (oral,rectal)
Use weight based dosing in children less than 12 years.
- 1 Day – 12 Years
- Use weight based dosing in children less than 12 years.
Acetaminophen
- Severity Level:
2
- Additional Notes: Available data suggest no known risk; otc product, no fda pregnancy warnings
Diphenhydramine
- Severity Level:
B
- Additional Notes:
Phenylephrine
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Diphenhydramine
Limited data suggest increased drowsiness, and irritability
Oral bioavailability low; infant exposure may be minimal
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest increased drowsiness, and irritability |
Phenylephrine
Limited data suggest increased drowsiness, and irritability
Oral bioavailability low; infant exposure may be minimal
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Oral bioavailability low; infant exposure may be minimal |
No Known Risk
Acetaminophen
Low levels excreted with low risk for adverse effects in infant
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Excreted | No adverse effect | Low levels excreted with low risk for adverse effects in infant |
Contraindicated
None
Precaution Exists
Acetaminophen (oral,rectal)
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Diphenhydramine
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Phenylephrine
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
Allergic conjunctivitis | |
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
Allergic rhinitis | |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
Flu-like symptoms | |
J02.9 | Acute pharyngitis, unspecified |
R05 | Cough |
R05.1 | Acute cough |
R05.2 | Subacute cough |
R05.9 | Cough, unspecified |
R09.81 | Nasal congestion |
R50.9 | Fever, unspecified |
R53.1 | Weakness |
R53.81 | Other malaise |
R53.83 | Other fatigue |
R68.83 | Chills (without fever) |
Nasal congestion | |
R09.81 | Nasal congestion |
Rhinorrhea | |
R09.82 | Postnasal drip |
Sinus headache | |
R51 | Headache |
R51.9 | Headache, unspecified |
0-9 | A-Z |
---|---|
H10.1 | Acute atopic conjunctivitis |
H10.10 | Acute atopic conjunctivitis, unspecified eye |
H10.11 | Acute atopic conjunctivitis, right eye |
H10.12 | Acute atopic conjunctivitis, left eye |
H10.13 | Acute atopic conjunctivitis, bilateral |
H10.44 | Vernal conjunctivitis |
H10.45 | Other chronic allergic conjunctivitis |
H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
J02.9 | Acute pharyngitis, unspecified |
J30.1 | Allergic rhinitis due to pollen |
J30.2 | Other seasonal allergic rhinitis |
J30.5 | Allergic rhinitis due to food |
J30.8 | Other allergic rhinitis |
J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
J30.89 | Other allergic rhinitis |
J30.9 | Allergic rhinitis, unspecified |
R05 | Cough |
R05.1 | Acute cough |
R05.2 | Subacute cough |
R05.9 | Cough, unspecified |
R09.81 | Nasal congestion |
R09.81 | Nasal congestion |
R09.82 | Postnasal drip |
R50.9 | Fever, unspecified |
R51 | Headache |
R51.9 | Headache, unspecified |
R53.1 | Weakness |
R53.81 | Other malaise |
R53.83 | Other fatigue |
R68.83 | Chills (without fever) |