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LATUDA (lurasidone HCl)
- bipolar depression
- schizophrenia
120 mg tablet
- 1 tablet (120 mg) by oral route once daily with food (at least 350 calories)
20 mg tablet
- 1 tablet (20 mg) by oral route once daily with food (at least 350 calories)
40 mg tablet
- 1 tablet (40 mg) by oral route once daily with food (at least 350 calories)
60 mg tablet
- 1 tablet (60 mg) by oral route once daily with food (at least 350 calories)
80 mg tablet
- 1 tablet (80 mg) by oral route once daily with food (at least 350 calories)
Depression associated with bipolar disorder
- 1 tablet (20 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (40 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (40 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (60 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (80 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (80 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (120 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (120 mg) by oral route once daily with food (at least 350 calories)
Schizophrenia
- 2 tablets (40 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (40 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (60 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (80 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (80 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (120 mg) by oral route once daily with food (at least 350 calories)
- 1 tablet (120 mg) by oral route once daily with food (at least 350 calories)
- 2 tablets (160 mg) by oral route once daily with food (at least 350 calories)
- amoxicil-clarithromy-lansopraz
- aprepitant
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Calan
- Calan Sr
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cerebyx
- clarithromycin
- Cold & Flu Fighter
- Crixivan
- Diflucan
- Dilacor Xr
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Dilt-xr
- diltiazem HCl
- Donnatal
- elvitegr-cobicist-emtric-tenof
- Emend
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Fatigue Relief Complex
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosaprepitant
- fosphenytoin
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lopinavir-ritonavir
- Luminal
- Matzim La
- metoclopramide HCl
- Metozolv Odt
- Mycobutin
- Mysoline
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Prevpac
- primidone
- Reglan
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- saquinavir mesylate
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Stribild
- Tarka
- Taztia Xt
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tiazac
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- Xtandi
Contraindicated
- cabergoline
Severe
Moderate
- Aplenzin
- Apokyn
- apomorphine
- Buproban
- bupropion HBr
- bupropion HCl
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- Forfivo Xl
- Juxtapid
- lomitapide
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zyban
- Neuroleptic malignant syndrome
Contraindicated
- Cerebrovascular accident
- Child-pugh class B hepatic impairment
- Child-pugh class C hepatic impairment
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Orthostatic hypotension
- Parkinsonism
- Senile dementia
- Severe hepatic disease
- Suicidal ideation
- Tardive dyskinesia
- Transient cerebral ischemia
Severe
Moderate
- Bipolar disorder
- Diabetes mellitus
- Dysphagia
- Esophageal dysmotility
- Hyperlipidemia
- Hyperprolactinemia
- Kidney disease with likely reduction in GFR
- Leukopenia
- Lower seizure threshold
- Neutropenic disorder
- Obesity
- Seizure disorder
- Weight gain
LATUDA (lurasidone HCl)
- bipolar depression
- schizophrenia
- Extrapyramidal disease
- Parkinsonism
- Acquired dystonia
- Akathisia
- Diarrhea
- Disorder of lipid metabolism
- Drowsy
- Dyspepsia
- Insomnia
- Nausea
- Symptoms of anxiety
- Vomiting
- Weight gain
More Frequent
Severe
Less Severe
- Kidney disease with reduction in GFR
- Tachycardia
- Acute abdominal pain
- Agitation
- Anorexia
- Blurred vision
- Dizziness
- Fatigue
- Hyperlipidemia
- Hyperprolactinemia
- Hypertension
- Nervousness
- Orthostatic hypotension
- Pain in oropharynx
- Pharyngitis
- Pruritus of skin
- Sialorrhea
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Agranulocytosis
- Angina
- Angioedema
- Atrioventricular block
- Bradycardia
- Cardiac arrhythmia
- Cerebrovascular accident
- Diabetes mellitus
- DRESS syndrome
- Dysphagia
- Esophageal dysmotility
- Hyperglycemia
- Hyponatremia
- Leukopenia
- Manic disorder
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Oculogyric crisis
- Pharyngeal edema
- Rhabdomyolysis
- Seizure disorder
- Sleep apnea
- Suicidal ideation
- Syncope
- Tardive dyskinesia
- Tongue swelling
- Transient cerebral ischemia
Less Severe
- Amenorrhea
- Back pain
- Complex sleep behavior
- Dysarthria
- Dysmenorrhea
- Dyspnea
- Dysuria
- Erectile dysfunction
- Galactorrhea not associated with childbirth
- Gynecomastia
- Hypomania
- Mastalgia
- Rhinitis
- Sleep walking disorder
- Urticaria
Contraindicated
None
Severe Precaution
Lurasidone
Risk of suicidal ideation. Potential effect on growth, development and neurobehavior. No safety and efficacy established age < 10 years.
- 1 Day – 10 Years
- Risk of suicidal ideation. Potential effect on growth, development and neurobehavior. No safety and efficacy established age < 10 years.
Management or Monitoring Precaution
Lurasidone
Risk of suicidal ideation. Potential effect on growth, development and neurobehavior. Monitor weight, blood glucose if symptoms of hyperglycemia present.
- 10 Years – 18 Years
- Risk of suicidal ideation. Potential effect on growth, development and neurobehavior. Monitor weight, blood glucose if symptoms of hyperglycemia present.
Lurasidone
- Severity Level:
2
- Additional Notes: Infants exposed in 3rd trimester may show signs of extrapyramidal symptoms
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Lurasidone
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Lurasidone
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects: sedation, cognit impair, and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm opt. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia; hyperglycemia risk and worse DM control. Renal-Do not exceed 40 mg/day for CrCl < 50 mL/min. Cardiovascular-May cause orthostatic hypoten at higher doses. Inc risk of QT prolong.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.<br /><br /> Lurasidone is used to treat certain mental/mood disorders (such as schizophrenia, depression associated with bipolar disorder). Drugs used to treat depression can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take drugs to treat depression may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of drugs used to treat depression (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new drug to treat depression is started or when the dose is changed.
| Depression associated with bipolar disorder | |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.3 | Bipolar disorder, current episode depressed, mild or moderate severity |
| F31.30 | Bipolar disorder, current episode depressed, mild or moderate severity, unspecified |
| F31.31 | Bipolar disorder, current episode depressed, mild |
| F31.32 | Bipolar disorder, current episode depressed, moderate |
| F31.4 | Bipolar disorder, current episode depressed, severe, without psychotic features |
| F31.5 | Bipolar disorder, current episode depressed, severe, with psychotic features |
Formulary Reference Tool