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ASPRUZYO SPRINKLE (ranolazine)
- prevent anginal chest pain in coronary artery disease
1,000 mg granules,extended release in packet
- 1 packet (1,000 mg) by oral route 2 times per day
500 mg granules,extended release in packet
- 1 packet (500 mg) by oral route 2 times per day
Default screening record
- 2 packets (1,000 mg) by oral route 2 times per day
- 1 packet (1,000 mg) by oral route 2 times per day
- 1 packet (500 mg) by oral route 2 times per day
- amoxicil-clarithromy-lansopraz
- aprepitant
- Aptivus
- artemether-lumefantrine
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Calan
- Calan Sr
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- clarithromycin
- Coartem
- Cold & Flu Fighter
- conivaptan in 5 % dextrose
- Crixivan
- crizotinib
- darunavir
- Diflucan
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Donnatal
- dronedarone
- elvitegr-cobicist-emtric-tenof
- Emend
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- ezetimibe-simvastatin
- Fatigue Relief Complex
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosaprepitant
- Gleevec
- imatinib
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Juxtapid
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lomitapide
- lopinavir-ritonavir
- Luminal
- Lysodren
- Matzim La
- mitotane
- Multaq
- Mycobutin
- Mysoline
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- posaconazole
- Prevpac
- Prezista
- Priftin
- primidone
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- saquinavir mesylate
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Stribild
- Tarka
- Taztia Xt
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tiazac
- tipranavir
- trandolapril-verapamil
- Vaprisol
- verapamil
- Verelan
- Verelan Pm
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Vytorin 10-40
- Vytorin 10-80
- Women's Complex
- Xalkori
- Xtandi
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- Cordarone
- disopyramide
- Fareston
- Hycamtin
- Nexterone
- Norpace
- Norpace Cr
- Pacerone
- propafenone
- Rythmol
- topotecan
- toremifene
Severe
Moderate
- Ablavar
- Actoplus Met
- Actoplus Met Xr
- Advair Diskus
- Advair Hfa
- Advicor
- afatinib
- alfuzosin
- alogliptin-metformin
- Aloxi
- Altoprev
- amantadine HCl
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anzemet
- Apokyn
- apomorphine
- arformoterol
- arsenic trioxide
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- bedaquiline
- Betapace
- Betapace Af
- Brovana
- budesonide-formoterol
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- chloroquine phosphate
- chlorpromazine
- clozapine
- Clozaril
- Corvert
- dasatinib
- dextromethorphan-quinidine
- Diamode
- Digox
- digoxin
- Diskets
- dofetilide
- dolasetron
- Dolophine
- droperidol
- Dulera
- Dutoprol
- Effexor Xr
- Eovist
- escitalopram oxalate
- Fazaclo
- felbamate
- Felbatol
- fingolimod
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- Fortamet
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- Geodon
- Gilenya
- Gilotrif
- glipizide-metformin
- Glucophage
- Glucophage Xr
- Glucovance
- Glumetza
- glyburide-metformin
- granisetron
- granisetron (PF)
- Granisol
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hecoria
- ibutilide fumarate
- Imodium Multi-symptom Relief
- indapamide
- Invega
- Invega Sustenna
- isradipine
- Istodax
- Janumet
- Janumet Xr
- Jentadueto
- Kazano
- Kombiglyze Xr
- Lanoxin
- Lanoxin Pediatric
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- linagliptin-metformin
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lopressor
- Lopressor Hct
- lovastatin
- metformin
- methadone
- Methadone Intensol
- Methadose
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Mevacor
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- niacin-lovastatin
- niacin-simvastatin
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
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- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Orap
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- palonosetron
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- pentamidine
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- pimozide
- pioglitazone-metformin
- Prandimet
- procainamide
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- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- repaglinide-metformin
- Riomet
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- rivaroxaban
- romidepsin
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- saxagliptin-metformin
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Simcor
- simvastatin
- Sirturo
- sitagliptin-metformin
- Soltamox
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tasigna
- thioridazine
- Tikosyn
- tizanidine
- Toprol Xl
- Trisenox
- Tykerb
- Ultra A-d
- Uniretic
- Univasc
- Uroxatral
- vandetanib
- vardenafil
- venlafaxine
- Versacloz
- Vytorin 10-10
- Vytorin 10-20
- Xarelto
- Zanaflex
- ziprasidone HCl
- ziprasidone mesylate
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zocor
- Zofran
- Zofran Odt
- Zuplenz
- Congenital long QT syndrome
- Hepatic cirrhosis
- Prolonged QT interval
- Torsades de pointes
Contraindicated
- Acute renal failure
Severe
Moderate
- Renal disease with moderate to severe impairment
ASPRUZYO SPRINKLE (ranolazine)
- prevent anginal chest pain in coronary artery disease
- None
- Constipation
- Dizziness
- Headache disorder
- Nausea
More Frequent
Severe
Less Severe
- None
- Acute abdominal pain
- Anorexia
- Dyspepsia
- Dyspnea
- General weakness
- Hyperhidrosis
- Palpitations
- Peripheral edema
- Tinnitus
- Vertigo
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Angioedema
- Bradycardia
- Eosinophilia
- Hematuria
- Hypotension
- Leukopenia
- Myoclonus
- Orthostatic hypotension
- Pancytopenia
- Prolonged QT interval
- Pulmonary fibrosis
- Renal failure
- Syncope
- Thrombocytopenic disorder
- Torsades de pointes
Less Severe
- Acute confusion
- Ataxia
- Blurred vision
- Dysuria
- Hallucinations
- Hypoesthesia
- Paresthesia
- Pruritus of skin
- Skin rash
- Tremor
- Urinary retention
- Urine discoloration
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Ranolazine
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Ranolazine
- Severity Level:
2
- Additional Notes: Insufficient human data available
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ranolazine
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Ranolazine
Renal-Plasma levels increased 40-50% in all degrees of renal impairment including CrCL<50 mL/min often seen in renal function decline of aging. Neuro/Psych-Increased risk of dose-related dizziness in elderly not associated with drops in systolic bp; consider fall risk. Gastrointestinal-Increased risk of nausea and constipation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Prevention of anginal pain in coronary artery disease | |
| I20.2 | Refractory angina pectoris |
| I20.81 | Angina pectoris with coronary microvascular dysfunction |
| I20.89 | Other forms of angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.112 | Atherosclerotic heart disease of native coronary artery with refractory angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.702 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with refractory angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.712 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with refractory angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.722 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with refractory angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.732 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with refractory angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.752 | Atherosclerosis of native coronary artery of transplanted heart with refractory angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.762 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with refractory angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.792 | Atherosclerosis of other coronary artery bypass graft(s) with refractory angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
| 0-9 | A-Z |
|---|---|
| I20.2 | Refractory angina pectoris |
| I20.81 | Angina pectoris with coronary microvascular dysfunction |
| I20.89 | Other forms of angina pectoris |
| I20.9 | Angina pectoris, unspecified |
| I25.112 | Atherosclerotic heart disease of native coronary artery with refractory angina pectoris |
| I25.118 | Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris |
| I25.119 | Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris |
| I25.702 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with refractory angina pectoris |
| I25.708 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris |
| I25.709 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris |
| I25.712 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with refractory angina pectoris |
| I25.718 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.719 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.722 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with refractory angina pectoris |
| I25.728 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.729 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.732 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with refractory angina pectoris |
| I25.738 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.739 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris |
| I25.752 | Atherosclerosis of native coronary artery of transplanted heart with refractory angina pectoris |
| I25.758 | Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris |
| I25.759 | Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris |
| I25.762 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with refractory angina pectoris |
| I25.768 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris |
| I25.769 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris |
| I25.792 | Atherosclerosis of other coronary artery bypass graft(s) with refractory angina pectoris |
| I25.798 | Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris |
| I25.799 | Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris |
Formulary Reference Tool